Iron in PDB 1h2n: Factor Inhibiting Hif-1 Alpha

All present enzymatic activity of Factor Inhibiting Hif-1 Alpha:
1.14.11.16;

The structure of Factor Inhibiting Hif-1 Alpha, PDB code: 1h2n was solved by J.M.Elkins, K.S.Hewitson, L.A.Mcneill, I.Schlemminger, J.F.Seibel, C.J.Schofield, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	30.00 / 2.84
Space group	P 41 21 2
Cell size a, b, c (Å), α, β, γ (°)	86.342, 86.342, 146.732, 90.00, 90.00, 90.00
R / Rfree (%)	23.1 / 25.7

The binding sites of Iron atom in the Factor Inhibiting Hif-1 Alpha (pdb code 1h2n). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total only one binding site of Iron was determined in the Factor Inhibiting Hif-1 Alpha, PDB code: 1h2n:

Iron binding site 1 out of 1 in the Factor Inhibiting Hif-1 Alpha


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Factor Inhibiting Hif-1 Alpha within 5.0Å range: probe atom residue distance (Å) B Occ A:Fe1350 b:32.5 occ:1.00 O1 A:AKG1351 1.8 39.0 1.0 OD2 A:ASP201 1.9 36.8 1.0 NE2 A:HIS199 2.0 32.8 1.0 NE2 A:HIS279 2.1 37.7 1.0 O5 A:AKG1351 2.3 33.4 1.0 C1 A:AKG1351 2.6 37.0 1.0 C2 A:AKG1351 2.8 35.2 1.0 CG A:ASP201 2.9 34.6 1.0 CE1 A:HIS199 2.9 32.4 1.0 CE1 A:HIS279 3.0 39.3 1.0 CD2 A:HIS199 3.0 32.9 1.0 OD1 A:ASP201 3.1 33.5 1.0 CD2 A:HIS279 3.1 38.1 1.0 O A:HOH2001 3.8 46.4 1.0 O2 A:AKG1351 3.8 37.3 1.0 ND1 A:HIS199 4.0 31.4 1.0 ND1 A:HIS279 4.1 39.5 1.0 CG A:HIS199 4.1 32.6 1.0 CG A:HIS279 4.2 37.1 1.0 C3 A:AKG1351 4.3 36.1 1.0 CB A:ASP201 4.3 34.5 1.0 CZ2 A:TRP296 4.3 41.0 1.0 C4 A:AKG1351 4.9 36.5 1.0

J.M.Elkins, K.S.Hewitson, L.A.Mcneill, J.F.Seibel, I.Schlemminger, C.Pugh, P.Ratcliffe, C.J.Schofield. Structure of Factor-Inhibiting Hypoxia-Inducible Factor (Hif) Reveals Mechanism of Oxidative Modification of Hif-1ALPHA J.Biol.Chem. V. 278 1802 2003.
ISSN: ISSN 0021-9258
PubMed: 12446723
DOI: 10.1074/JBC.C200644200