Iron in PDB 1hu9: Lipoxygenase-3 (Soybean) Complex with 4-Hydroperoxy-2-Methoxy-Phenol

All present enzymatic activity of Lipoxygenase-3 (Soybean) Complex with 4-Hydroperoxy-2-Methoxy-Phenol:
1.13.11.12;

The structure of Lipoxygenase-3 (Soybean) Complex with 4-Hydroperoxy-2-Methoxy-Phenol, PDB code: 1hu9 was solved by K.Zhou, E.Skrzypczak-Jankun, N.P.Mccabe, S.H.Selman, J.Jankun, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	40.00 / 2.20
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	112.790, 137.320, 61.870, 90.00, 95.55, 90.00
R / Rfree (%)	18.5 / 27.1

The binding sites of Iron atom in the Lipoxygenase-3 (Soybean) Complex with 4-Hydroperoxy-2-Methoxy-Phenol (pdb code 1hu9). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total only one binding site of Iron was determined in the Lipoxygenase-3 (Soybean) Complex with 4-Hydroperoxy-2-Methoxy-Phenol, PDB code: 1hu9:

Iron binding site 1 out of 1 in the Lipoxygenase-3 (Soybean) Complex with 4-Hydroperoxy-2-Methoxy-Phenol


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Lipoxygenase-3 (Soybean) Complex with 4-Hydroperoxy-2-Methoxy-Phenol within 5.0Å range: probe atom residue distance (Å) B Occ A:Fe858 b:30.5 occ:1.00 O8 A:4HM861 2.0 42.3 1.0 OXT A:ILE857 2.1 29.9 1.0 NE2 A:HIS523 2.2 22.2 1.0 NE2 A:HIS518 2.2 28.8 1.0 NE2 A:HIS709 2.2 22.4 1.0 OD1 A:ASN713 2.2 34.8 1.0 C A:ILE857 3.0 28.3 1.0 CE1 A:HIS518 3.1 26.3 1.0 O7 A:4HM861 3.1 53.3 1.0 CE1 A:HIS709 3.1 20.0 1.0 CE1 A:HIS523 3.2 17.9 1.0 O A:ILE857 3.2 30.5 1.0 CD2 A:HIS523 3.3 8.8 1.0 CD2 A:HIS709 3.4 21.0 1.0 CG A:ASN713 3.4 21.5 1.0 CD2 A:HIS518 3.4 28.1 1.0 C4 A:4HM861 4.0 59.5 1.0 CB A:ASN713 4.1 12.4 1.0 ND1 A:HIS518 4.3 28.1 1.0 ND1 A:HIS709 4.3 17.7 1.0 ND1 A:HIS523 4.3 10.3 1.0 ND2 A:ASN713 4.4 21.4 1.0 CA A:ILE857 4.4 21.1 1.0 CG A:HIS523 4.4 10.4 1.0 CG A:HIS518 4.5 24.0 1.0 CG A:HIS709 4.5 21.0 1.0 CG2 A:ILE855 4.5 15.4 1.0 C5 A:4HM861 4.6 62.4 1.0 N A:ILE857 4.8 24.5 1.0 C3 A:4HM861 4.9 64.4 1.0

E.Skrzypczak-Jankun, K.Zhou, N.P.Mccabe, S.H.Selman, J.Jankun. Structure of Curcumin in Complex with Lipoxygenase and Its Significance in Cancer. Int.J.Mol.Med. V. 12 17 2003.
ISSN: ISSN 1107-3756
PubMed: 12792803