Iron in PDB 1j8t: Catalytic Domain of Human Phenylalanine Hydroxylase Fe(II)

All present enzymatic activity of Catalytic Domain of Human Phenylalanine Hydroxylase Fe(II):
1.14.16.1;

The structure of Catalytic Domain of Human Phenylalanine Hydroxylase Fe(II), PDB code: 1j8t was solved by O.A.Andersen, T.Flatmark, E.Hough, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	10.00 / 1.70
Space group	C 2 2 21
Cell size a, b, c (Å), α, β, γ (°)	66.334, 108.419, 124.024, 90.00, 90.00, 90.00
R / Rfree (%)	19.4 / 25.2

The binding sites of Iron atom in the Catalytic Domain of Human Phenylalanine Hydroxylase Fe(II) (pdb code 1j8t). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total only one binding site of Iron was determined in the Catalytic Domain of Human Phenylalanine Hydroxylase Fe(II), PDB code: 1j8t:

Iron binding site 1 out of 1 in the Catalytic Domain of Human Phenylalanine Hydroxylase Fe(II)


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Catalytic Domain of Human Phenylalanine Hydroxylase Fe(II) within 5.0Å range: probe atom residue distance (Å) B Occ A:Fe428 b:42.0 occ:1.00 NE2 A:HIS290 2.1 24.9 1.0 NE2 A:HIS285 2.1 26.1 1.0 OE2 A:GLU330 2.3 30.5 1.0 O A:HOH1243 2.6 36.3 1.0 CD2 A:HIS290 3.0 25.6 1.0 CD2 A:HIS285 3.0 24.3 1.0 CE1 A:HIS290 3.1 23.3 1.0 CE1 A:HIS285 3.1 29.3 1.0 CD A:GLU330 3.4 38.8 1.0 CG A:HIS290 4.2 23.8 1.0 ND1 A:HIS290 4.2 25.1 1.0 OE1 A:GLU330 4.2 81.1 1.0 CG A:HIS285 4.2 26.5 1.0 ND1 A:HIS285 4.2 33.4 1.0 CG A:GLU330 4.2 37.1 1.0 CB A:ALA345 4.3 21.6 1.0 OE2 A:GLU286 4.3 24.2 1.0 CB A:PRO281 4.9 25.7 1.0

O.A.Andersen, T.Flatmark, E.Hough. High Resolution Crystal Structures of the Catalytic Domain of Human Phenylalanine Hydroxylase in Its Catalytically Active Fe(II) Form and Binary Complex with Tetrahydrobiopterin. J.Mol.Biol. V. 314 279 2001.
ISSN: ISSN 0022-2836
PubMed: 11718561
DOI: 10.1006/JMBI.2001.5061