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Iron in PDB 1ltz: Crystal Structure of Chromobacterium Violaceum Phenylalanine Hydroxylase, Structure Has Bound Iron (III) and Oxidized Cofactor 7, 8-Dihydrobiopterin

Enzymatic activity of Crystal Structure of Chromobacterium Violaceum Phenylalanine Hydroxylase, Structure Has Bound Iron (III) and Oxidized Cofactor 7, 8-Dihydrobiopterin

All present enzymatic activity of Crystal Structure of Chromobacterium Violaceum Phenylalanine Hydroxylase, Structure Has Bound Iron (III) and Oxidized Cofactor 7, 8-Dihydrobiopterin:
1.14.16.1;

Protein crystallography data

The structure of Crystal Structure of Chromobacterium Violaceum Phenylalanine Hydroxylase, Structure Has Bound Iron (III) and Oxidized Cofactor 7, 8-Dihydrobiopterin, PDB code: 1ltz was solved by H.Erlandsen, J.Y.Kim, M.G.Patch, A.Han, A.Volner, M.M.Abu-Omar, R.C.Stevens, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 20.00 / 1.40
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 46.700, 67.860, 91.470, 90.00, 90.00, 90.00
R / Rfree (%) 15.9 / 22.3

Other elements in 1ltz:

The structure of Crystal Structure of Chromobacterium Violaceum Phenylalanine Hydroxylase, Structure Has Bound Iron (III) and Oxidized Cofactor 7, 8-Dihydrobiopterin also contains other interesting chemical elements:

Chlorine (Cl) 1 atom

Iron Binding Sites:

The binding sites of Iron atom in the Crystal Structure of Chromobacterium Violaceum Phenylalanine Hydroxylase, Structure Has Bound Iron (III) and Oxidized Cofactor 7, 8-Dihydrobiopterin (pdb code 1ltz). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total only one binding site of Iron was determined in the Crystal Structure of Chromobacterium Violaceum Phenylalanine Hydroxylase, Structure Has Bound Iron (III) and Oxidized Cofactor 7, 8-Dihydrobiopterin, PDB code: 1ltz:

Iron binding site 1 out of 1 in 1ltz

Go back to Iron Binding Sites List in 1ltz
Iron binding site 1 out of 1 in the Crystal Structure of Chromobacterium Violaceum Phenylalanine Hydroxylase, Structure Has Bound Iron (III) and Oxidized Cofactor 7, 8-Dihydrobiopterin


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Crystal Structure of Chromobacterium Violaceum Phenylalanine Hydroxylase, Structure Has Bound Iron (III) and Oxidized Cofactor 7, 8-Dihydrobiopterin within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Fe400

b:15.4
occ:1.00
 NE2 A:HIS138 2.1 15.1 1.0
O A:HOH1003 2.1 20.5 1.0
NE2 A:HIS143 2.2 13.9 1.0
OE2 A:GLU184 2.2 18.1 1.0
O A:HOH1002 2.2 19.1 1.0
OE1 A:GLU184 2.2 17.1 1.0
CD A:GLU184 2.6 16.6 1.0
CE1 A:HIS138 3.1 16.4 1.0
CD2 A:HIS143 3.1 15.9 1.0
CD2 A:HIS138 3.2 16.1 1.0
CE1 A:HIS143 3.2 14.8 1.0
O A:HOH1004 4.0 22.9 1.0
CG A:GLU184 4.1 16.4 1.0
O A:HOH1188 4.2 49.3 1.0
O4 A:HBI500 4.2 26.5 1.0
ND1 A:HIS138 4.2 17.0 1.0
OD1 A:ASP139 4.2 23.9 1.0
CG A:HIS138 4.3 16.3 1.0
ND1 A:HIS143 4.3 15.5 1.0
CG A:HIS143 4.3 15.9 1.0
O A:HOH1006 4.5 31.6 1.0
CB A:ALA199 4.8 16.0 1.0
CG A:PRO134 4.9 33.6 1.0
CB A:GLU184 5.0 13.7 1.0

Reference:

H.Erlandsen, J.Y.Kim, M.G.Patch, A.Han, A.Volner, M.M.Abu-Omar, R.C.Stevens. Structural Comparison of Bacterial and Human Iron-Dependent Phenylalanine Hydroxylases: Similar Fold, Different Stability and Reaction Rates. J.Mol.Biol. V. 320 645 2002.
ISSN: ISSN 0022-2836
PubMed: 12096915
DOI: 10.1016/S0022-2836(02)00496-5
Page generated: Sat Aug 3 09:55:17 2024

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