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Iron in PDB 1lwl: Crystal Structure of Cytochrome P450-Cam with A Fluorescent Probe D-8-Ad (Adamantane-1-Carboxylic Acid-5-Dimethylamino- Naphthalene-1-Sulfonylamino-Octyl-Amide)

Enzymatic activity of Crystal Structure of Cytochrome P450-Cam with A Fluorescent Probe D-8-Ad (Adamantane-1-Carboxylic Acid-5-Dimethylamino- Naphthalene-1-Sulfonylamino-Octyl-Amide)

All present enzymatic activity of Crystal Structure of Cytochrome P450-Cam with A Fluorescent Probe D-8-Ad (Adamantane-1-Carboxylic Acid-5-Dimethylamino- Naphthalene-1-Sulfonylamino-Octyl-Amide):
1.14.15.1;

Protein crystallography data

The structure of Crystal Structure of Cytochrome P450-Cam with A Fluorescent Probe D-8-Ad (Adamantane-1-Carboxylic Acid-5-Dimethylamino- Naphthalene-1-Sulfonylamino-Octyl-Amide), PDB code: 1lwl was solved by A.R.Dunn, A.M.Hays, D.B.Goodin, C.D.Stout, R.Chiu, J.R.Winkler, H.B.Gray, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 20.00 / 2.20
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 64.955, 75.313, 93.178, 90.00, 90.00, 90.00
R / Rfree (%) 20.2 / 24.7

Iron Binding Sites:

The binding sites of Iron atom in the Crystal Structure of Cytochrome P450-Cam with A Fluorescent Probe D-8-Ad (Adamantane-1-Carboxylic Acid-5-Dimethylamino- Naphthalene-1-Sulfonylamino-Octyl-Amide) (pdb code 1lwl). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total only one binding site of Iron was determined in the Crystal Structure of Cytochrome P450-Cam with A Fluorescent Probe D-8-Ad (Adamantane-1-Carboxylic Acid-5-Dimethylamino- Naphthalene-1-Sulfonylamino-Octyl-Amide), PDB code: 1lwl:

Iron binding site 1 out of 1 in 1lwl

Go back to Iron Binding Sites List in 1lwl
Iron binding site 1 out of 1 in the Crystal Structure of Cytochrome P450-Cam with A Fluorescent Probe D-8-Ad (Adamantane-1-Carboxylic Acid-5-Dimethylamino- Naphthalene-1-Sulfonylamino-Octyl-Amide)


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Crystal Structure of Cytochrome P450-Cam with A Fluorescent Probe D-8-Ad (Adamantane-1-Carboxylic Acid-5-Dimethylamino- Naphthalene-1-Sulfonylamino-Octyl-Amide) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Fe417

b:11.9
occ:1.00
 FE A:HEM417 0.0 11.9 1.0
NC A:HEM417 2.0 15.9 1.0
NB A:HEM417 2.1 15.1 1.0
NA A:HEM417 2.1 15.8 1.0
ND A:HEM417 2.1 17.6 1.0
SG A:CYS357 2.4 20.1 1.0
C1C A:HEM417 3.0 18.3 1.0
C1D A:HEM417 3.0 19.0 1.0
C4B A:HEM417 3.0 15.6 1.0
C4A A:HEM417 3.0 14.4 1.0
C1B A:HEM417 3.0 17.0 1.0
C4C A:HEM417 3.1 16.9 1.0
C4D A:HEM417 3.1 17.5 1.0
C1A A:HEM417 3.1 16.9 1.0
CHC A:HEM417 3.3 15.4 1.0
CHB A:HEM417 3.3 15.8 1.0
CHD A:HEM417 3.3 16.0 1.0
CHA A:HEM417 3.4 11.8 1.0
CB A:CYS357 3.4 12.4 1.0
CA A:CYS357 4.2 17.1 1.0
C2C A:HEM417 4.2 19.0 1.0
C2D A:HEM417 4.2 17.2 1.0
C3A A:HEM417 4.3 14.3 1.0
C3D A:HEM417 4.3 15.7 1.0
C3C A:HEM417 4.3 18.6 1.0
C3B A:HEM417 4.3 17.6 1.0
C2B A:HEM417 4.3 15.4 1.0
C2A A:HEM417 4.3 15.8 1.0
C1 A:DSO900 4.4 21.4 1.0
O A:GLY248 4.5 21.2 1.0
N A:GLY359 4.6 16.6 1.0
C A:CYS357 4.9 13.4 1.0
C5 A:DSO900 4.9 27.3 1.0
N A:LEU358 4.9 12.2 1.0
CA A:GLY359 5.0 15.3 1.0

Reference:

A.R.Dunn, A.M.Hays, D.B.Goodin, C.D.Stout, R.Chiu, J.R.Winkler, H.B.Gray. Fluorescent Probes For Cytochrome P450 Structural Characterization and Inhibitor Screening J.Am.Chem.Soc. V. 124 10254 2002.
ISSN: ISSN 0002-7863
PubMed: 12197708
DOI: 10.1021/JA0271678
Page generated: Sat Aug 3 09:56:21 2024

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