Iron in PDB 1mze: Human Factor Inhibiting Hif (FIH1)

The structure of Human Factor Inhibiting Hif (FIH1), PDB code: 1mze was solved by C.E.Dann Iii, R.K.Bruick, J.Deisenhofer, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	29.99 / 2.20
Space group	P 41 21 2
Cell size a, b, c (Å), α, β, γ (°)	86.620, 86.620, 147.760, 90.00, 90.00, 90.00
R / Rfree (%)	21.6 / 23.7

The binding sites of Iron atom in the Human Factor Inhibiting Hif (FIH1) (pdb code 1mze). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total only one binding site of Iron was determined in the Human Factor Inhibiting Hif (FIH1), PDB code: 1mze:

Iron binding site 1 out of 1 in the Human Factor Inhibiting Hif (FIH1)


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Human Factor Inhibiting Hif (FIH1) within 5.0Å range: probe atom residue distance (Å) B Occ A:Fe400 b:45.8 occ:1.00 O41 A:TAR500 2.1 61.5 1.0 OD2 A:ASP201 2.2 44.5 1.0 NE2 A:HIS279 2.2 35.5 1.0 NE2 A:HIS199 2.3 41.3 1.0 O4 A:TAR500 2.5 65.4 1.0 C4 A:TAR500 2.6 67.1 1.0 CE1 A:HIS199 3.1 41.1 1.0 CD2 A:HIS279 3.1 34.6 1.0 CG A:ASP201 3.2 45.8 1.0 CE1 A:HIS279 3.2 34.6 1.0 CD2 A:HIS199 3.3 37.8 1.0 OD1 A:ASP201 3.5 48.2 1.0 C3 A:TAR500 4.1 67.3 1.0 O A:HOH553 4.1 50.6 1.0 ND1 A:HIS199 4.2 39.5 1.0 ND1 A:HIS279 4.3 37.5 1.0 CG A:HIS279 4.3 34.8 1.0 CG A:HIS199 4.3 38.3 1.0 O3 A:TAR500 4.5 66.9 1.0 CB A:ASP201 4.6 39.0 1.0 CZ2 A:TRP296 4.7 59.5 1.0 C2 A:TAR500 4.8 68.0 1.0

C.E.Dann Iii, R.K.Bruick, J.Deisenhofer. Structure of Factor-Inhibiting Hypoxia-Inducible Factor 1: An Asparaginyl Hydroxylase Involved in the Hypoxic Response Pathway Proc.Natl.Acad.Sci.Usa V. 99 15351 2002.
ISSN: ISSN 0027-8424
PubMed: 12432100
DOI: 10.1073/PNAS.202614999