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Iron in PDB 1mzf: Human Factor Inhibiting Hif (FIH1) in Complex with 2-Oxoglutarate

Protein crystallography data

The structure of Human Factor Inhibiting Hif (FIH1) in Complex with 2-Oxoglutarate, PDB code: 1mzf was solved by C.E.Dann Iii, R.K.Bruick, J.Deisenhofer, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 29.93 / 2.40
Space group P 41 21 2
Cell size a, b, c (Å), α, β, γ (°) 86.460, 86.460, 147.810, 90.00, 90.00, 90.00
R / Rfree (%) 23.2 / 24.4

Iron Binding Sites:

The binding sites of Iron atom in the Human Factor Inhibiting Hif (FIH1) in Complex with 2-Oxoglutarate (pdb code 1mzf). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total only one binding site of Iron was determined in the Human Factor Inhibiting Hif (FIH1) in Complex with 2-Oxoglutarate, PDB code: 1mzf:

Iron binding site 1 out of 1 in 1mzf

Go back to Iron Binding Sites List in 1mzf
Iron binding site 1 out of 1 in the Human Factor Inhibiting Hif (FIH1) in Complex with 2-Oxoglutarate


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Human Factor Inhibiting Hif (FIH1) in Complex with 2-Oxoglutarate within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Fe400

b:52.5
occ:0.60
O1 A:AKG600 1.9 73.6 0.4
NE2 A:HIS279 2.2 40.4 1.0
NE2 A:HIS199 2.2 48.2 1.0
O5 A:AKG600 2.3 73.7 0.4
OD2 A:ASP201 2.5 50.5 1.0
C1 A:AKG600 2.7 73.8 0.4
CE1 A:HIS199 2.8 47.8 1.0
C2 A:AKG600 2.9 74.1 0.4
CD2 A:HIS279 3.1 38.5 1.0
CE1 A:HIS279 3.3 39.3 1.0
CD2 A:HIS199 3.4 45.2 1.0
CG A:ASP201 3.5 49.6 1.0
OD1 A:ASP201 3.7 49.6 1.0
O2 A:AKG600 3.9 74.4 0.4
CH2 A:TRP296 3.9 72.2 1.0
ND1 A:HIS199 4.0 45.6 1.0
O A:HOH650 4.1 60.5 1.0
CG A:HIS279 4.3 39.6 1.0
C3 A:AKG600 4.3 73.9 0.4
ND1 A:HIS279 4.3 42.4 1.0
CG A:HIS199 4.4 45.9 1.0
CZ2 A:TRP296 4.5 71.9 1.0
CB A:ASP201 4.8 46.2 1.0
CZ3 A:TRP296 5.0 71.6 1.0

Reference:

C.E.Dann Iii, R.K.Bruick, J.Deisenhofer. Structure of Factor-Inhibiting Hypoxia-Inducible Factor 1: An Asparaginyl Hydroxylase Involved in the Hypoxic Response Pathway. Proc.Natl.Acad.Sci.Usa V. 99 15351 2002.
ISSN: ISSN 0027-8424
PubMed: 12432100
DOI: 10.1073/PNAS.202614999
Page generated: Sun Dec 13 14:24:46 2020

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