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Iron in PDB 1p6h: Rat Neuronal Nos Heme Domain with L-N(Omega)-Nitroarginine- 2,4-L-Diaminobutyric Amide Bound

Enzymatic activity of Rat Neuronal Nos Heme Domain with L-N(Omega)-Nitroarginine- 2,4-L-Diaminobutyric Amide Bound

All present enzymatic activity of Rat Neuronal Nos Heme Domain with L-N(Omega)-Nitroarginine- 2,4-L-Diaminobutyric Amide Bound:
1.14.13.39;

Protein crystallography data

The structure of Rat Neuronal Nos Heme Domain with L-N(Omega)-Nitroarginine- 2,4-L-Diaminobutyric Amide Bound, PDB code: 1p6h was solved by M.L.Flinspach, H.Li, J.Jamal, W.Yang, H.Huang, J.-M.Hah, J.A.Gomez-Vidal, E.A.Litzinger, R.B.Silverman, T.L.Poulos, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 43.94 / 1.98
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 51.940, 110.220, 164.770, 90.00, 90.00, 90.00
R / Rfree (%) 23.1 / 27.3

Other elements in 1p6h:

The structure of Rat Neuronal Nos Heme Domain with L-N(Omega)-Nitroarginine- 2,4-L-Diaminobutyric Amide Bound also contains other interesting chemical elements:

Zinc (Zn) 1 atom

Iron Binding Sites:

The binding sites of Iron atom in the Rat Neuronal Nos Heme Domain with L-N(Omega)-Nitroarginine- 2,4-L-Diaminobutyric Amide Bound (pdb code 1p6h). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total 2 binding sites of Iron where determined in the Rat Neuronal Nos Heme Domain with L-N(Omega)-Nitroarginine- 2,4-L-Diaminobutyric Amide Bound, PDB code: 1p6h:
Jump to Iron binding site number: 1; 2;

Iron binding site 1 out of 2 in 1p6h

Go back to Iron Binding Sites List in 1p6h
Iron binding site 1 out of 2 in the Rat Neuronal Nos Heme Domain with L-N(Omega)-Nitroarginine- 2,4-L-Diaminobutyric Amide Bound


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Rat Neuronal Nos Heme Domain with L-N(Omega)-Nitroarginine- 2,4-L-Diaminobutyric Amide Bound within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Fe750

b:26.9
occ:1.00
FE A:HEM750 0.0 26.9 1.0
NC A:HEM750 2.0 26.8 1.0
ND A:HEM750 2.0 28.4 1.0
NB A:HEM750 2.0 27.5 1.0
NA A:HEM750 2.0 28.3 1.0
SG A:CYS415 2.2 29.9 1.0
C4C A:HEM750 3.0 26.6 1.0
C1D A:HEM750 3.0 27.3 1.0
C1B A:HEM750 3.0 27.4 1.0
C1C A:HEM750 3.1 27.2 1.0
C4D A:HEM750 3.1 27.0 1.0
C4A A:HEM750 3.1 27.7 1.0
C1A A:HEM750 3.1 27.6 1.0
C4B A:HEM750 3.1 27.5 1.0
CB A:CYS415 3.3 29.4 1.0
CHD A:HEM750 3.4 27.6 1.0
CHB A:HEM750 3.4 27.1 1.0
CHA A:HEM750 3.5 27.0 1.0
CHC A:HEM750 3.5 27.7 1.0
CA A:CYS415 4.1 28.5 1.0
NH1 A:DP1790 4.2 33.0 1.0
C3C A:HEM750 4.2 26.5 1.0
C2D A:HEM750 4.3 27.3 1.0
C3D A:HEM750 4.3 27.4 1.0
C2C A:HEM750 4.3 27.1 1.0
C2B A:HEM750 4.3 27.6 1.0
C2A A:HEM750 4.3 27.4 1.0
C3A A:HEM750 4.3 27.9 1.0
C3B A:HEM750 4.3 28.3 1.0
NE1 A:TRP409 4.4 23.5 1.0
NO A:DP1790 4.5 33.0 1.0
CZ A:DP1790 4.6 34.3 1.0
C A:CYS415 4.8 28.3 1.0
O3 A:DP1790 4.8 32.8 1.0
N A:VAL416 4.9 27.4 1.0
N A:GLY417 4.9 27.1 1.0
O2 A:DP1790 4.9 33.9 1.0
NH2 A:DP1790 5.0 31.8 1.0

Iron binding site 2 out of 2 in 1p6h

Go back to Iron Binding Sites List in 1p6h
Iron binding site 2 out of 2 in the Rat Neuronal Nos Heme Domain with L-N(Omega)-Nitroarginine- 2,4-L-Diaminobutyric Amide Bound


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 2 of Rat Neuronal Nos Heme Domain with L-N(Omega)-Nitroarginine- 2,4-L-Diaminobutyric Amide Bound within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Fe750

b:24.0
occ:1.00
FE B:HEM750 0.0 24.0 1.0
NC B:HEM750 2.0 23.3 1.0
NA B:HEM750 2.0 24.5 1.0
ND B:HEM750 2.0 23.7 1.0
NB B:HEM750 2.0 24.2 1.0
SG B:CYS415 2.2 25.2 1.0
C1A B:HEM750 3.0 24.1 1.0
C4D B:HEM750 3.0 23.7 1.0
C4C B:HEM750 3.0 23.2 1.0
C4B B:HEM750 3.0 25.4 1.0
C1D B:HEM750 3.1 23.2 1.0
C1B B:HEM750 3.1 25.4 1.0
C1C B:HEM750 3.1 23.6 1.0
C4A B:HEM750 3.1 25.1 1.0
CB B:CYS415 3.4 23.3 1.0
CHA B:HEM750 3.4 23.3 1.0
CHD B:HEM750 3.4 22.5 1.0
CHC B:HEM750 3.4 24.1 1.0
CHB B:HEM750 3.5 25.0 1.0
NH1 B:DP1791 4.2 30.8 1.0
CA B:CYS415 4.2 23.8 1.0
C2A B:HEM750 4.2 24.9 1.0
C3C B:HEM750 4.3 23.6 1.0
C2C B:HEM750 4.3 23.2 1.0
C3D B:HEM750 4.3 24.0 1.0
C3B B:HEM750 4.3 26.3 1.0
C2B B:HEM750 4.3 25.9 1.0
C3A B:HEM750 4.3 24.0 1.0
C2D B:HEM750 4.3 23.7 1.0
NO B:DP1791 4.4 29.6 1.0
NE1 B:TRP409 4.5 23.1 1.0
CZ B:DP1791 4.6 30.3 1.0
O2 B:DP1791 4.6 30.2 1.0
N B:GLY417 4.8 26.3 1.0
NH2 B:DP1791 4.9 28.8 1.0
C B:CYS415 4.9 24.7 1.0
O3 B:DP1791 4.9 30.4 1.0

Reference:

M.L.Flinspach, H.Li, J.Jamal, W.Yang, H.Huang, J.M.Hah, J.A.Gomez-Vidal, E.A.Litzinger, R.B.Silverman, T.L.Poulos. Structural Basis For Dipeptide Amide Isoform-Selective Inhibition of Neuronal Nitric Oxide Synthase. Nat.Struct.Mol.Biol. V. 11 54 2004.
ISSN: ISSN 1545-9993
PubMed: 14718923
DOI: 10.1038/NSMB704
Page generated: Sat Aug 3 12:57:34 2024

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