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Iron in PDB 1prh: The X-Ray Crystal Structure of the Membrane Protein Prostaglandin H2 Synthase-1

Enzymatic activity of The X-Ray Crystal Structure of the Membrane Protein Prostaglandin H2 Synthase-1

All present enzymatic activity of The X-Ray Crystal Structure of the Membrane Protein Prostaglandin H2 Synthase-1:
1.14.99.1;

Protein crystallography data

The structure of The X-Ray Crystal Structure of the Membrane Protein Prostaglandin H2 Synthase-1, PDB code: 1prh was solved by D.Picot, P.J.Loll, R.M.Garavito, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 20.00 / 3.50
Space group I 2 2 2
Cell size a, b, c (Å), α, β, γ (°) 99.400, 210.300, 233.100, 90.00, 90.00, 90.00
R / Rfree (%) 26.7 / 31.6

Iron Binding Sites:

The binding sites of Iron atom in the The X-Ray Crystal Structure of the Membrane Protein Prostaglandin H2 Synthase-1 (pdb code 1prh). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total 2 binding sites of Iron where determined in the The X-Ray Crystal Structure of the Membrane Protein Prostaglandin H2 Synthase-1, PDB code: 1prh:
Jump to Iron binding site number: 1; 2;

Iron binding site 1 out of 2 in 1prh

Go back to Iron Binding Sites List in 1prh
Iron binding site 1 out of 2 in the The X-Ray Crystal Structure of the Membrane Protein Prostaglandin H2 Synthase-1


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of The X-Ray Crystal Structure of the Membrane Protein Prostaglandin H2 Synthase-1 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Fe601

b:15.0
occ:1.00
FE A:HEM601 0.0 15.0 1.0
ND A:HEM601 1.9 15.0 1.0
NC A:HEM601 1.9 15.0 1.0
NB A:HEM601 2.0 15.0 1.0
NA A:HEM601 2.0 15.0 1.0
NE2 A:HIS388 2.1 15.0 1.0
C1D A:HEM601 3.0 15.0 1.0
C4C A:HEM601 3.0 15.0 1.0
C4D A:HEM601 3.0 15.0 1.0
C4B A:HEM601 3.0 15.0 1.0
C1C A:HEM601 3.0 15.0 1.0
C1B A:HEM601 3.0 15.0 1.0
C1A A:HEM601 3.0 15.0 1.0
C4A A:HEM601 3.0 15.0 1.0
CD2 A:HIS388 3.1 15.0 1.0
CE1 A:HIS388 3.1 15.0 1.0
CHD A:HEM601 3.3 15.0 1.0
CHA A:HEM601 3.4 15.0 1.0
CHC A:HEM601 3.4 15.0 1.0
CHB A:HEM601 3.4 15.0 1.0
CG A:HIS388 4.2 15.0 1.0
C2D A:HEM601 4.2 15.0 1.0
C3D A:HEM601 4.2 15.0 1.0
C3C A:HEM601 4.2 15.0 1.0
ND1 A:HIS388 4.2 15.0 1.0
C3B A:HEM601 4.2 15.0 1.0
C2C A:HEM601 4.3 15.0 1.0
C2B A:HEM601 4.3 15.0 1.0
C3A A:HEM601 4.3 15.0 1.0
C2A A:HEM601 4.3 15.0 1.0
NE2 A:HIS207 4.5 15.0 1.0
CE1 A:HIS207 4.6 15.0 1.0
OE1 A:GLN203 4.7 15.0 1.0

Iron binding site 2 out of 2 in 1prh

Go back to Iron Binding Sites List in 1prh
Iron binding site 2 out of 2 in the The X-Ray Crystal Structure of the Membrane Protein Prostaglandin H2 Synthase-1


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 2 of The X-Ray Crystal Structure of the Membrane Protein Prostaglandin H2 Synthase-1 within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Fe601

b:15.0
occ:1.00
FE B:HEM601 0.0 15.0 1.0
ND B:HEM601 1.9 15.0 1.0
NC B:HEM601 1.9 15.0 1.0
NB B:HEM601 2.0 15.0 1.0
NA B:HEM601 2.0 15.0 1.0
NE2 B:HIS388 2.1 15.0 1.0
C1D B:HEM601 3.0 15.0 1.0
C4C B:HEM601 3.0 15.0 1.0
C4D B:HEM601 3.0 15.0 1.0
C4B B:HEM601 3.0 15.0 1.0
C1C B:HEM601 3.0 15.0 1.0
C1B B:HEM601 3.0 15.0 1.0
C1A B:HEM601 3.0 15.0 1.0
C4A B:HEM601 3.0 15.0 1.0
CD2 B:HIS388 3.1 15.0 1.0
CE1 B:HIS388 3.1 15.0 1.0
CHD B:HEM601 3.3 15.0 1.0
CHA B:HEM601 3.4 15.0 1.0
CHC B:HEM601 3.4 15.0 1.0
CHB B:HEM601 3.4 15.0 1.0
CG B:HIS388 4.2 15.0 1.0
C2D B:HEM601 4.2 15.0 1.0
C3D B:HEM601 4.2 15.0 1.0
C3C B:HEM601 4.2 15.0 1.0
ND1 B:HIS388 4.2 15.0 1.0
C3B B:HEM601 4.2 15.0 1.0
C3A B:HEM601 4.3 15.0 1.0
C2C B:HEM601 4.3 15.0 1.0
C2B B:HEM601 4.3 15.0 1.0
C2A B:HEM601 4.3 15.0 1.0
NE2 B:HIS207 4.5 15.0 1.0
CE1 B:HIS207 4.6 15.0 1.0
OE1 B:GLN203 4.7 15.0 1.0

Reference:

D.Picot, P.J.Loll, R.M.Garavito. The X-Ray Crystal Structure of the Membrane Protein Prostaglandin H2 Synthase-1. Nature V. 367 243 1994.
ISSN: ISSN 0028-0836
PubMed: 8121489
DOI: 10.1038/367243A0
Page generated: Sat Aug 3 13:12:56 2024

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