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Iron in PDB 1pxx: Crystal Structure of Diclofenac Bound to the Cyclooxygenase Active Site of Cox-2
Enzymatic activity of Crystal Structure of Diclofenac Bound to the Cyclooxygenase Active Site of Cox-2
All present enzymatic activity of Crystal Structure of Diclofenac Bound to the Cyclooxygenase Active Site of Cox-2:
1.14.99.1;
1.14.99.1;
Protein crystallography data
The structure of Crystal Structure of Diclofenac Bound to the Cyclooxygenase Active Site of Cox-2, PDB code: 1pxx
was solved by
J.R.Kiefer,
S.W.Rowlinson,
J.J.Prusakiewicz,
J.L.Pawlitz,
K.R.Kozak,
A.S.Kalgutkar,
W.C.Stallings,
L.J.Marnett,
R.G.Kurumbail,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 20.00 / 2.90 |
| Space group | P 21 21 2 |
| Cell size a, b, c (Å), α, β, γ (°) | 181.145, 135.090, 124.165, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 25.4 / 30.2 |
Other elements in 1pxx:
The structure of Crystal Structure of Diclofenac Bound to the Cyclooxygenase Active Site of Cox-2 also contains other interesting chemical elements:
| Chlorine | (Cl) | 8 atoms |
Iron Binding Sites:
The binding sites of Iron atom in the Crystal Structure of Diclofenac Bound to the Cyclooxygenase Active Site of Cox-2
(pdb code 1pxx). This binding sites where shown within
5.0 Angstroms radius around Iron atom.
In total 4 binding sites of Iron where determined in the Crystal Structure of Diclofenac Bound to the Cyclooxygenase Active Site of Cox-2, PDB code: 1pxx:
Jump to Iron binding site number: 1; 2; 3; 4;
In total 4 binding sites of Iron where determined in the Crystal Structure of Diclofenac Bound to the Cyclooxygenase Active Site of Cox-2, PDB code: 1pxx:
Jump to Iron binding site number: 1; 2; 3; 4;
Iron binding site 1 out of 4 in 1pxx
Go back to
Iron Binding Sites List in 1pxx
Iron binding site 1 out
of 4 in the Crystal Structure of Diclofenac Bound to the Cyclooxygenase Active Site of Cox-2
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Iron with other atoms in the Fe binding
site number 1 of Crystal Structure of Diclofenac Bound to the Cyclooxygenase Active Site of Cox-2 within 5.0Å range:
|
Iron binding site 2 out of 4 in 1pxx
Go back to
Iron Binding Sites List in 1pxx
Iron binding site 2 out
of 4 in the Crystal Structure of Diclofenac Bound to the Cyclooxygenase Active Site of Cox-2
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Iron with other atoms in the Fe binding
site number 2 of Crystal Structure of Diclofenac Bound to the Cyclooxygenase Active Site of Cox-2 within 5.0Å range:
|
Iron binding site 3 out of 4 in 1pxx
Go back to
Iron Binding Sites List in 1pxx
Iron binding site 3 out
of 4 in the Crystal Structure of Diclofenac Bound to the Cyclooxygenase Active Site of Cox-2
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Iron with other atoms in the Fe binding
site number 3 of Crystal Structure of Diclofenac Bound to the Cyclooxygenase Active Site of Cox-2 within 5.0Å range:
|
Iron binding site 4 out of 4 in 1pxx
Go back to
Iron Binding Sites List in 1pxx
Iron binding site 4 out
of 4 in the Crystal Structure of Diclofenac Bound to the Cyclooxygenase Active Site of Cox-2
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Iron with other atoms in the Fe binding
site number 4 of Crystal Structure of Diclofenac Bound to the Cyclooxygenase Active Site of Cox-2 within 5.0Å range:
|
Reference:
S.W.Rowlinson,
J.R.Kiefer,
J.J.Prusakiewicz,
J.L.Pawlitz,
K.R.Kozak,
A.S.Kalgutkar,
W.C.Stallings,
R.G.Kurumbail,
L.J.Marnett.
A Novel Mechanism of Cyclooxygenase-2 Inhibition Involving Interactions with Ser-530 and Tyr-385. J.Biol.Chem. V. 278 45763 2003.
ISSN: ISSN 0021-9258
PubMed: 12925531
DOI: 10.1074/JBC.M305481200
Page generated: Sat Aug 3 13:14:16 2024
ISSN: ISSN 0021-9258
PubMed: 12925531
DOI: 10.1074/JBC.M305481200
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