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Iron in PDB 1w69: Crystal Structure of Mouse Ribonucleotide Reductase Subunit R2 Under Reducing Conditions. A Fully Occupied Dinuclear Iron Cluster and Bound Acetate.

Enzymatic activity of Crystal Structure of Mouse Ribonucleotide Reductase Subunit R2 Under Reducing Conditions. A Fully Occupied Dinuclear Iron Cluster and Bound Acetate.

All present enzymatic activity of Crystal Structure of Mouse Ribonucleotide Reductase Subunit R2 Under Reducing Conditions. A Fully Occupied Dinuclear Iron Cluster and Bound Acetate.:
1.17.4.1;

Protein crystallography data

The structure of Crystal Structure of Mouse Ribonucleotide Reductase Subunit R2 Under Reducing Conditions. A Fully Occupied Dinuclear Iron Cluster and Bound Acetate., PDB code: 1w69 was solved by S.Karlsen, K.R.Strand, M.Kolberg, A.K.Rohr, C.H.Gorbitz, K.K.Andersson, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 21.80 / 2.20
Space group C 2 2 21
Cell size a, b, c (Å), α, β, γ (°) 75.993, 107.454, 91.929, 90.00, 90.00, 90.00
R / Rfree (%) 21.7 / 27.2

Iron Binding Sites:

The binding sites of Iron atom in the Crystal Structure of Mouse Ribonucleotide Reductase Subunit R2 Under Reducing Conditions. A Fully Occupied Dinuclear Iron Cluster and Bound Acetate. (pdb code 1w69). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total 2 binding sites of Iron where determined in the Crystal Structure of Mouse Ribonucleotide Reductase Subunit R2 Under Reducing Conditions. A Fully Occupied Dinuclear Iron Cluster and Bound Acetate., PDB code: 1w69:
Jump to Iron binding site number: 1; 2;

Iron binding site 1 out of 2 in 1w69

Go back to Iron Binding Sites List in 1w69
Iron binding site 1 out of 2 in the Crystal Structure of Mouse Ribonucleotide Reductase Subunit R2 Under Reducing Conditions. A Fully Occupied Dinuclear Iron Cluster and Bound Acetate.


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Crystal Structure of Mouse Ribonucleotide Reductase Subunit R2 Under Reducing Conditions. A Fully Occupied Dinuclear Iron Cluster and Bound Acetate. within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Fe1349

b:52.2
occ:1.00
 OD2 A:ASP139 2.0 61.6 1.0
ND1 A:HIS173 2.2 28.5 1.0
OE2 A:GLU267 2.2 56.1 1.0
OE2 A:GLU170 2.2 42.3 1.0
O A:ACY1351 2.7 60.6 1.0
CE1 A:HIS173 3.1 32.7 1.0
CG A:ASP139 3.2 61.4 1.0
CG A:HIS173 3.3 31.9 1.0
CD A:GLU170 3.3 39.7 1.0
CD A:GLU267 3.3 55.8 1.0
C A:ACY1351 3.3 60.3 1.0
OXT A:ACY1351 3.3 58.5 1.0
FE A:FE21350 3.4 41.2 1.0
CB A:HIS173 3.7 36.7 1.0
OE1 A:GLU170 3.7 42.0 1.0
OE1 A:GLU267 4.0 59.2 1.0
OD1 A:ASP139 4.0 63.5 1.0
CB A:ASP139 4.2 56.6 1.0
NE2 A:HIS173 4.2 33.4 1.0
CG A:GLU267 4.3 52.7 1.0
CD2 A:HIS173 4.3 35.5 1.0
CG2 A:ILE263 4.5 42.4 1.0
CA A:GLU170 4.5 32.8 1.0
CE1 A:HIS270 4.6 35.5 1.0
CG A:GLU170 4.6 37.0 1.0
ND1 A:HIS270 4.6 33.7 1.0
CH3 A:ACY1351 4.7 60.7 1.0
CB A:GLU170 4.8 31.9 1.0
CA A:ASP139 4.9 54.8 1.0

Iron binding site 2 out of 2 in 1w69

Go back to Iron Binding Sites List in 1w69
Iron binding site 2 out of 2 in the Crystal Structure of Mouse Ribonucleotide Reductase Subunit R2 Under Reducing Conditions. A Fully Occupied Dinuclear Iron Cluster and Bound Acetate.


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 2 of Crystal Structure of Mouse Ribonucleotide Reductase Subunit R2 Under Reducing Conditions. A Fully Occupied Dinuclear Iron Cluster and Bound Acetate. within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Fe1350

b:41.2
occ:1.00
 OE2 A:GLU233 1.7 46.8 1.0
OE1 A:GLU170 2.0 42.0 1.0
OXT A:ACY1351 2.1 58.5 1.0
ND1 A:HIS270 2.2 33.7 1.0
OE1 A:GLU267 2.3 59.2 1.0
OE2 A:GLU267 2.5 56.1 1.0
CD A:GLU267 2.7 55.8 1.0
CD A:GLU233 2.9 46.2 1.0
CD A:GLU170 3.0 39.7 1.0
CE1 A:HIS270 3.1 35.5 1.0
C A:ACY1351 3.2 60.3 1.0
OE2 A:GLU170 3.2 42.3 1.0
CG A:HIS270 3.3 35.9 1.0
FE A:FE21349 3.4 52.2 1.0
CG A:GLU233 3.6 46.1 1.0
CB A:HIS270 3.7 33.4 1.0
O A:ACY1351 3.8 60.6 1.0
OE1 A:GLU233 3.9 47.4 1.0
NE2 A:GLN166 4.1 35.0 1.0
CG A:GLU267 4.2 52.7 1.0
NE2 A:HIS270 4.3 35.0 1.0
CH3 A:ACY1351 4.3 60.7 1.0
CG A:GLU170 4.4 37.0 1.0
CB A:GLU233 4.4 47.1 1.0
CD2 A:HIS270 4.4 29.1 1.0
CA A:GLU267 4.5 42.6 1.0
CG1 A:VAL142 4.6 42.0 1.0
CB A:GLU267 4.8 43.0 1.0
ND1 A:HIS173 4.9 28.5 1.0
CE1 A:HIS173 4.9 32.7 1.0
CG A:GLN166 4.9 31.7 1.0
CD A:GLN166 4.9 34.9 1.0
OD2 A:ASP139 5.0 61.6 1.0

Reference:

K.R.Strand, S.Karlsen, M.Kolberg, A.K.Rohr, C.H.Gorbitz, K.K.Andersson. Crystal Structural Studies of Changes in the Native Dinuclear Iron Center of Ribonucleotide Reductase Protein R2 From Mouse J.Biol.Chem. V. 279 46794 2004.
ISSN: ISSN 0021-9258
PubMed: 15322079
DOI: 10.1074/JBC.M407346200
Page generated: Sat Aug 3 16:27:06 2024

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