Iron in PDB 1xz4: Intersubunit Interactions Associated with TYR42ALPHA Stabilize the Quaternary-T Tetramer But Are Not Major Quaternary Constraints in Deoxyhemoglobin: ALPHAY42A Deoxyhemoglobin No-Salt

The structure of Intersubunit Interactions Associated with TYR42ALPHA Stabilize the Quaternary-T Tetramer But Are Not Major Quaternary Constraints in Deoxyhemoglobin: ALPHAY42A Deoxyhemoglobin No-Salt, PDB code: 1xz4 was solved by J.S.Kavanaugh, P.H.Rogers, A.Arnone, H.L.Hui, A.Wierzba, A.Deyoung, L.D.Kwiatkowski, R.W.Noble, L.J.Juszczak, E.S.Peterson, J.M.Friedman, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	10.00 / 2.00
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	84.100, 111.900, 64.000, 90.00, 90.00, 90.00
R / Rfree (%)	18.3 / 22.4

The binding sites of Iron atom in the Intersubunit Interactions Associated with TYR42ALPHA Stabilize the Quaternary-T Tetramer But Are Not Major Quaternary Constraints in Deoxyhemoglobin: ALPHAY42A Deoxyhemoglobin No-Salt (pdb code 1xz4). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total 4 binding sites of Iron where determined in the Intersubunit Interactions Associated with TYR42ALPHA Stabilize the Quaternary-T Tetramer But Are Not Major Quaternary Constraints in Deoxyhemoglobin: ALPHAY42A Deoxyhemoglobin No-Salt, PDB code: 1xz4:
Jump to Iron binding site number: 1; 2; 3; 4;

Iron binding site 1 out of 4 in the Intersubunit Interactions Associated with TYR42ALPHA Stabilize the Quaternary-T Tetramer But Are Not Major Quaternary Constraints in Deoxyhemoglobin: ALPHAY42A Deoxyhemoglobin No-Salt


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Intersubunit Interactions Associated with TYR42ALPHA Stabilize the Quaternary-T Tetramer But Are Not Major Quaternary Constraints in Deoxyhemoglobin: ALPHAY42A Deoxyhemoglobin No-Salt within 5.0Å range: probe atom residue distance (Å) B Occ A:Fe142 b:28.2 occ:1.00 FE A:HEM142 0.0 28.2 1.0 NC A:HEM142 2.0 25.5 1.0 NB A:HEM142 2.1 27.4 1.0 NA A:HEM142 2.1 28.7 1.0 ND A:HEM142 2.1 26.5 1.0 NE2 A:HIS87 2.2 25.7 1.0 C1C A:HEM142 3.0 22.4 1.0 CE1 A:HIS87 3.0 28.6 1.0 C4C A:HEM142 3.0 26.8 1.0 C4B A:HEM142 3.0 23.1 1.0 C4D A:HEM142 3.1 27.0 1.0 C1A A:HEM142 3.1 28.0 1.0 C1B A:HEM142 3.1 27.1 1.0 C1D A:HEM142 3.1 27.3 1.0 C4A A:HEM142 3.1 28.0 1.0 CHC A:HEM142 3.4 23.5 1.0 CD2 A:HIS87 3.4 26.6 1.0 CHA A:HEM142 3.4 26.6 1.0 CHD A:HEM142 3.5 27.0 1.0 CHB A:HEM142 3.5 30.1 1.0 O A:HOH267 3.7 40.3 1.0 ND1 A:HIS87 4.2 25.2 1.0 C2C A:HEM142 4.2 23.8 1.0 C3C A:HEM142 4.2 25.6 1.0 C3B A:HEM142 4.3 25.4 1.0 C2B A:HEM142 4.3 24.2 1.0 C2A A:HEM142 4.3 30.9 1.0 CE1 A:HIS58 4.3 39.8 1.0 C3D A:HEM142 4.3 29.0 1.0 C3A A:HEM142 4.4 31.4 1.0 C2D A:HEM142 4.4 27.5 1.0 CD1 A:LEU91 4.4 36.0 1.0 CG A:HIS87 4.4 26.3 1.0 NE2 A:HIS58 4.4 39.0 1.0

Iron binding site 2 out of 4 in the Intersubunit Interactions Associated with TYR42ALPHA Stabilize the Quaternary-T Tetramer But Are Not Major Quaternary Constraints in Deoxyhemoglobin: ALPHAY42A Deoxyhemoglobin No-Salt


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 2 of Intersubunit Interactions Associated with TYR42ALPHA Stabilize the Quaternary-T Tetramer But Are Not Major Quaternary Constraints in Deoxyhemoglobin: ALPHAY42A Deoxyhemoglobin No-Salt within 5.0Å range: probe atom residue distance (Å) B Occ B:Fe147 b:17.8 occ:1.00 FE B:HEM147 0.0 17.8 1.0 NA B:HEM147 2.0 16.9 1.0 ND B:HEM147 2.0 16.3 1.0 NB B:HEM147 2.1 13.7 1.0 NE2 B:HIS92 2.1 14.7 1.0 NC B:HEM147 2.2 13.2 1.0 CE1 B:HIS92 3.0 16.7 1.0 C1A B:HEM147 3.0 18.9 1.0 C4D B:HEM147 3.0 18.0 1.0 C1B B:HEM147 3.1 16.9 1.0 C4B B:HEM147 3.1 17.2 1.0 C4A B:HEM147 3.1 17.8 1.0 C1D B:HEM147 3.1 17.1 1.0 C1C B:HEM147 3.2 10.5 1.0 CD2 B:HIS92 3.2 16.7 1.0 C4C B:HEM147 3.2 13.6 1.0 CHA B:HEM147 3.4 17.8 1.0 CHC B:HEM147 3.5 12.6 1.0 CHB B:HEM147 3.5 17.0 1.0 CHD B:HEM147 3.5 15.7 1.0 CG2 B:VAL67 4.2 21.1 1.0 ND1 B:HIS92 4.2 14.5 1.0 C2A B:HEM147 4.3 21.9 1.0 C2B B:HEM147 4.3 17.7 1.0 NE2 B:HIS63 4.3 22.5 1.0 C3B B:HEM147 4.3 16.6 1.0 C3A B:HEM147 4.3 19.7 1.0 CG B:HIS92 4.3 14.2 1.0 C2D B:HEM147 4.3 18.9 1.0 C3D B:HEM147 4.3 20.4 1.0 C2C B:HEM147 4.4 12.3 1.0 C3C B:HEM147 4.4 15.1 1.0 CE1 B:HIS63 4.6 26.1 1.0 CD1 B:LEU96 4.7 17.9 1.0

Iron binding site 3 out of 4 in the Intersubunit Interactions Associated with TYR42ALPHA Stabilize the Quaternary-T Tetramer But Are Not Major Quaternary Constraints in Deoxyhemoglobin: ALPHAY42A Deoxyhemoglobin No-Salt


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 3 of Intersubunit Interactions Associated with TYR42ALPHA Stabilize the Quaternary-T Tetramer But Are Not Major Quaternary Constraints in Deoxyhemoglobin: ALPHAY42A Deoxyhemoglobin No-Salt within 5.0Å range: probe atom residue distance (Å) B Occ C:Fe142 b:17.8 occ:1.00 FE C:HEM142 0.0 17.8 1.0 NB C:HEM142 2.0 17.5 1.0 NC C:HEM142 2.0 17.9 1.0 ND C:HEM142 2.1 16.4 1.0 NA C:HEM142 2.1 19.4 1.0 NE2 C:HIS87 2.2 15.7 1.0 C4B C:HEM142 3.1 15.9 1.0 C1C C:HEM142 3.1 15.5 1.0 C4C C:HEM142 3.1 14.9 1.0 C1A C:HEM142 3.1 16.2 1.0 C1D C:HEM142 3.1 17.5 1.0 CE1 C:HIS87 3.1 16.5 1.0 C1B C:HEM142 3.1 17.1 1.0 C4D C:HEM142 3.1 14.8 1.0 C4A C:HEM142 3.1 16.6 1.0 CD2 C:HIS87 3.3 15.2 1.0 CHC C:HEM142 3.4 17.5 1.0 CHA C:HEM142 3.4 15.3 1.0 CHD C:HEM142 3.4 17.0 1.0 CHB C:HEM142 3.5 15.2 1.0 O C:HOH263 3.6 23.2 1.0 C2C C:HEM142 4.2 17.8 1.0 ND1 C:HIS87 4.2 18.0 1.0 C3C C:HEM142 4.2 16.0 1.0 C2B C:HEM142 4.3 17.8 1.0 C3B C:HEM142 4.3 19.1 1.0 C2A C:HEM142 4.3 21.5 1.0 C2D C:HEM142 4.3 17.5 1.0 C3A C:HEM142 4.3 19.5 1.0 C3D C:HEM142 4.3 17.3 1.0 CG C:HIS87 4.4 15.7 1.0 CE1 C:HIS58 4.5 25.2 1.0 CD1 C:LEU91 4.5 25.6 1.0 NE2 C:HIS58 4.5 21.7 1.0

Iron binding site 4 out of 4 in the Intersubunit Interactions Associated with TYR42ALPHA Stabilize the Quaternary-T Tetramer But Are Not Major Quaternary Constraints in Deoxyhemoglobin: ALPHAY42A Deoxyhemoglobin No-Salt


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 4 of Intersubunit Interactions Associated with TYR42ALPHA Stabilize the Quaternary-T Tetramer But Are Not Major Quaternary Constraints in Deoxyhemoglobin: ALPHAY42A Deoxyhemoglobin No-Salt within 5.0Å range: probe atom residue distance (Å) B Occ D:Fe147 b:20.8 occ:1.00 FE D:HEM147 0.0 20.8 1.0 ND D:HEM147 2.0 20.1 1.0 NA D:HEM147 2.1 22.6 1.0 NB D:HEM147 2.1 19.9 1.0 NE2 D:HIS92 2.1 19.6 1.0 NC D:HEM147 2.1 19.5 1.0 CE1 D:HIS92 2.9 22.0 1.0 C4D D:HEM147 3.0 20.2 1.0 C1A D:HEM147 3.1 21.9 1.0 C1B D:HEM147 3.1 19.1 1.0 C1D D:HEM147 3.1 19.9 1.0 C4B D:HEM147 3.1 18.9 1.0 C1C D:HEM147 3.1 18.4 1.0 C4A D:HEM147 3.1 21.9 1.0 C4C D:HEM147 3.1 16.6 1.0 CD2 D:HIS92 3.2 22.0 1.0 CHA D:HEM147 3.4 23.1 1.0 CHB D:HEM147 3.4 22.1 1.0 CHC D:HEM147 3.5 17.6 1.0 CHD D:HEM147 3.5 18.2 1.0 ND1 D:HIS92 4.1 18.9 1.0 CG2 D:VAL67 4.3 21.3 1.0 CG D:HIS92 4.3 19.3 1.0 C2B D:HEM147 4.3 21.7 1.0 C2A D:HEM147 4.3 25.5 1.0 C3D D:HEM147 4.3 23.1 1.0 C3B D:HEM147 4.3 19.0 1.0 C3A D:HEM147 4.3 22.3 1.0 C2D D:HEM147 4.3 20.3 1.0 C3C D:HEM147 4.3 19.6 1.0 C2C D:HEM147 4.3 19.9 1.0 NE2 D:HIS63 4.4 34.0 1.0 CE1 D:HIS63 4.6 33.8 1.0 CD1 D:LEU96 5.0 28.7 1.0

J.S.Kavanaugh, P.H.Rogers, A.Arnone, H.L.Hui, A.Wierzba, A.Deyoung, L.D.Kwiatkowski, R.W.Noble, L.J.Juszczak, E.S.Peterson, J.M.Friedman. Intersubunit Interactions Associated with TYR42ALPHA Stabilize the Quaternary-T Tetramer But Are Not Major Quaternary Constraints in Deoxyhemoglobin Biochemistry V. 44 3806 2005.
ISSN: ISSN 0006-2960
PubMed: 15751957
DOI: 10.1021/BI0484670