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Iron in PDB 1zzq: Rat Nnos D597N Mutant with L-N(Omega)-Nitroarginine-(4R)- Amino-L-Proline Amide Bound

Enzymatic activity of Rat Nnos D597N Mutant with L-N(Omega)-Nitroarginine-(4R)- Amino-L-Proline Amide Bound

All present enzymatic activity of Rat Nnos D597N Mutant with L-N(Omega)-Nitroarginine-(4R)- Amino-L-Proline Amide Bound:
1.14.13.39;

Protein crystallography data

The structure of Rat Nnos D597N Mutant with L-N(Omega)-Nitroarginine-(4R)- Amino-L-Proline Amide Bound, PDB code: 1zzq was solved by H.Li, M.L.Flinspach, J.Igarashi, J.Jamal, W.Yang, J.A.Gomez-Vidal, E.A.Litzinger, R.B.Silverman, T.L.Poulos, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 35.89 / 1.90
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 51.860, 110.320, 164.600, 90.00, 90.00, 90.00
R / Rfree (%) 22 / 24.4

Other elements in 1zzq:

The structure of Rat Nnos D597N Mutant with L-N(Omega)-Nitroarginine-(4R)- Amino-L-Proline Amide Bound also contains other interesting chemical elements:

Zinc (Zn) 1 atom

Iron Binding Sites:

The binding sites of Iron atom in the Rat Nnos D597N Mutant with L-N(Omega)-Nitroarginine-(4R)- Amino-L-Proline Amide Bound (pdb code 1zzq). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total 2 binding sites of Iron where determined in the Rat Nnos D597N Mutant with L-N(Omega)-Nitroarginine-(4R)- Amino-L-Proline Amide Bound, PDB code: 1zzq:
Jump to Iron binding site number: 1; 2;

Iron binding site 1 out of 2 in 1zzq

Go back to Iron Binding Sites List in 1zzq
Iron binding site 1 out of 2 in the Rat Nnos D597N Mutant with L-N(Omega)-Nitroarginine-(4R)- Amino-L-Proline Amide Bound


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Rat Nnos D597N Mutant with L-N(Omega)-Nitroarginine-(4R)- Amino-L-Proline Amide Bound within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Fe750

b:22.7
occ:1.00
FE A:HEM750 0.0 22.7 1.0
NA A:HEM750 2.0 24.3 1.0
NC A:HEM750 2.0 23.7 1.0
ND A:HEM750 2.0 23.9 1.0
NB A:HEM750 2.0 24.0 1.0
SG A:CYS415 2.3 24.1 1.0
C1A A:HEM750 3.0 24.1 1.0
C4C A:HEM750 3.0 23.5 1.0
C1C A:HEM750 3.0 23.7 1.0
C1D A:HEM750 3.1 23.5 1.0
C4D A:HEM750 3.1 23.6 1.0
C4A A:HEM750 3.1 24.2 1.0
C1B A:HEM750 3.1 23.8 1.0
C4B A:HEM750 3.1 23.8 1.0
CB A:CYS415 3.3 23.7 1.0
CHD A:HEM750 3.4 23.7 1.0
CHA A:HEM750 3.4 23.6 1.0
CHC A:HEM750 3.5 23.9 1.0
CHB A:HEM750 3.5 23.9 1.0
CA A:CYS415 4.1 23.6 1.0
NH1 A:DP9799 4.2 35.3 0.5
C2A A:HEM750 4.3 24.4 1.0
C3C A:HEM750 4.3 23.6 1.0
C2D A:HEM750 4.3 23.5 1.0
C2C A:HEM750 4.3 24.0 1.0
C3D A:HEM750 4.3 23.6 1.0
C3A A:HEM750 4.3 24.6 1.0
C2B A:HEM750 4.3 24.1 1.0
C3B A:HEM750 4.4 23.9 1.0
NE1 A:TRP409 4.5 23.2 1.0
NH1 A:DP9799 4.5 34.5 0.5
NO A:DP9799 4.5 34.5 0.5
CZ A:DP9799 4.5 35.8 0.5
NO A:DP9799 4.5 35.1 0.5
CZ A:DP9799 4.7 35.0 0.5
O2 A:DP9799 4.7 34.6 0.5
O3 A:DP9799 4.8 34.1 0.5
C A:CYS415 4.8 23.3 1.0
NH2 A:DP9799 4.9 35.2 0.5
N A:GLY417 4.9 23.8 1.0
O2 A:DP9799 4.9 35.2 0.5
N A:VAL416 5.0 23.5 1.0
NH2 A:DP9799 5.0 34.5 0.5
O3 A:DP9799 5.0 34.9 0.5

Iron binding site 2 out of 2 in 1zzq

Go back to Iron Binding Sites List in 1zzq
Iron binding site 2 out of 2 in the Rat Nnos D597N Mutant with L-N(Omega)-Nitroarginine-(4R)- Amino-L-Proline Amide Bound


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 2 of Rat Nnos D597N Mutant with L-N(Omega)-Nitroarginine-(4R)- Amino-L-Proline Amide Bound within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Fe750

b:20.1
occ:1.00
FE B:HEM750 0.0 20.1 1.0
NC B:HEM750 2.0 21.4 1.0
NB B:HEM750 2.0 21.9 1.0
ND B:HEM750 2.0 21.5 1.0
NA B:HEM750 2.0 21.5 1.0
SG B:CYS415 2.2 21.3 1.0
C4B B:HEM750 3.0 22.4 1.0
C1C B:HEM750 3.0 21.8 1.0
C4C B:HEM750 3.0 21.5 1.0
C1D B:HEM750 3.1 21.3 1.0
C1B B:HEM750 3.1 22.0 1.0
C4D B:HEM750 3.1 21.4 1.0
C1A B:HEM750 3.1 21.5 1.0
C4A B:HEM750 3.1 21.9 1.0
CB B:CYS415 3.3 20.1 1.0
CHC B:HEM750 3.4 22.1 1.0
CHD B:HEM750 3.4 21.7 1.0
CHA B:HEM750 3.4 21.3 1.0
CHB B:HEM750 3.5 22.0 1.0
NH1 B:DP9800 4.1 35.8 0.5
CA B:CYS415 4.1 20.3 1.0
C2C B:HEM750 4.3 21.8 1.0
C3B B:HEM750 4.3 22.8 1.0
C2B B:HEM750 4.3 22.4 1.0
C3C B:HEM750 4.3 21.9 1.0
C3D B:HEM750 4.3 22.1 1.0
C2D B:HEM750 4.3 21.8 1.0
C2A B:HEM750 4.3 22.2 1.0
C3A B:HEM750 4.4 21.7 1.0
NE1 B:TRP409 4.4 19.1 1.0
NO B:DP9800 4.4 34.0 0.5
NO B:DP9800 4.4 35.5 0.5
O2 B:DP9800 4.5 34.2 0.5
NH1 B:DP9800 4.5 34.1 0.5
CZ B:DP9800 4.5 36.1 0.5
CZ B:DP9800 4.6 34.5 0.5
O2 B:DP9800 4.7 35.8 0.5
N B:GLY417 4.8 20.6 1.0
C B:CYS415 4.8 20.5 1.0
O3 B:DP9800 4.9 33.8 0.5
NH2 B:DP9800 4.9 34.2 0.5
NH2 B:DP9800 4.9 35.6 0.5
N B:VAL416 5.0 20.2 1.0

Reference:

H.Li, M.L.Flinspach, J.Igarashi, J.Jamal, W.Yang, E.A.Litzinger, H.Huang, E.P.Erdal, R.B.Silverman, T.L.Poulos. Exploring the Binding Conformations of Bulkier Dipeptide Amide Inhibitors in Constitutive Nitric Oxide Synthases. Biochemistry V. 44 15222 2005.
ISSN: ISSN 0006-2960
PubMed: 16285725
DOI: 10.1021/BI0513610
Page generated: Sat Aug 3 18:45:32 2024

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