Iron in PDB 2a1x: Human Phytanoyl-Coa 2-Hydroxylase in Complex with Iron and 2- Oxoglutarate

All present enzymatic activity of Human Phytanoyl-Coa 2-Hydroxylase in Complex with Iron and 2- Oxoglutarate:
1.14.11.18;

The structure of Human Phytanoyl-Coa 2-Hydroxylase in Complex with Iron and 2- Oxoglutarate, PDB code: 2a1x was solved by K.L.Kavanagh, M.A.Mcdonough, T.Searles, D.Butler, G.Bunkoczi, F.Von Delft, A.Edwards, C.Arrowsmith, M.Sundstrom, C.J.Schofield, U.Oppermann, Structural Genomics Consortium (Sgc), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	30.44 / 2.50
Space group	I 2 2 2
Cell size a, b, c (Å), α, β, γ (°)	67.929, 86.677, 97.541, 90.00, 90.00, 90.00
R / Rfree (%)	20.4 / 27.4

The binding sites of Iron atom in the Human Phytanoyl-Coa 2-Hydroxylase in Complex with Iron and 2- Oxoglutarate (pdb code 2a1x). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total only one binding site of Iron was determined in the Human Phytanoyl-Coa 2-Hydroxylase in Complex with Iron and 2- Oxoglutarate, PDB code: 2a1x:

Iron binding site 1 out of 1 in the Human Phytanoyl-Coa 2-Hydroxylase in Complex with Iron and 2- Oxoglutarate


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Human Phytanoyl-Coa 2-Hydroxylase in Complex with Iron and 2- Oxoglutarate within 5.0Å range: probe atom residue distance (Å) B Occ A:Fe450 b:40.1 occ:1.00 O2 A:AKG451 2.0 38.5 1.0 O A:HOH463 2.2 44.5 1.0 NE2 A:HIS175 2.2 40.4 1.0 NE2 A:HIS264 2.2 31.5 1.0 O5 A:AKG451 2.3 35.0 1.0 OD1 A:ASP177 2.3 24.6 1.0 C1 A:AKG451 2.8 51.2 1.0 C2 A:AKG451 2.9 55.5 1.0 CE1 A:HIS175 2.9 30.6 1.0 CE1 A:HIS264 3.1 38.0 1.0 CD2 A:HIS264 3.2 32.2 1.0 CG A:ASP177 3.3 26.5 1.0 CD2 A:HIS175 3.3 37.1 1.0 OD2 A:ASP177 3.6 39.6 1.0 O1 A:AKG451 4.1 38.8 1.0 ND1 A:HIS175 4.1 28.3 1.0 ND1 A:HIS264 4.2 34.6 1.0 CG A:HIS175 4.3 24.8 1.0 CG A:HIS264 4.3 31.6 1.0 C3 A:AKG451 4.4 55.1 1.0 CB A:ASP177 4.6 28.7 1.0 C4 A:AKG451 4.9 61.3 1.0 N A:ASP177 4.9 28.9 1.0 CA A:ASP177 4.9 30.8 1.0 CZ A:PHE258 5.0 36.6 1.0

M.A.Mcdonough, K.L.Kavanagh, D.Butler, T.Searles, U.Oppermann, C.J.Schofield. Structure of Human Phytanoyl-Coa 2-Hydroxylase Identifies Molecular Mechanisms of Refsum Disease J.Biol.Chem. V. 280 41101 2005.
ISSN: ISSN 0021-9258
PubMed: 16186124
DOI: 10.1074/JBC.M507528200