Atomistry » Iron » PDB 2c2c-2ciy » 2cgn
Atomistry »
  Iron »
    PDB 2c2c-2ciy »
      2cgn »

Iron in PDB 2cgn: Factor Inhibiting Hif-1 Alpha with Succinate

Enzymatic activity of Factor Inhibiting Hif-1 Alpha with Succinate

All present enzymatic activity of Factor Inhibiting Hif-1 Alpha with Succinate:
1.14.11.16;

Protein crystallography data

The structure of Factor Inhibiting Hif-1 Alpha with Succinate, PDB code: 2cgn was solved by M.A.Mcdonough, I.J.Clifton, C.J.Schofield, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 74.54 / 2.40
Space group P 41 21 2
Cell size a, b, c (Å), α, β, γ (°) 86.606, 86.606, 145.942, 90.00, 90.00, 90.00
R / Rfree (%) 20.5 / 26.3

Iron Binding Sites:

The binding sites of Iron atom in the Factor Inhibiting Hif-1 Alpha with Succinate (pdb code 2cgn). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total only one binding site of Iron was determined in the Factor Inhibiting Hif-1 Alpha with Succinate, PDB code: 2cgn:

Iron binding site 1 out of 1 in 2cgn

Go back to Iron Binding Sites List in 2cgn
Iron binding site 1 out of 1 in the Factor Inhibiting Hif-1 Alpha with Succinate


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Factor Inhibiting Hif-1 Alpha with Succinate within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Fe1350

b:54.2
occ:1.00
OD2 A:ASP201 2.0 54.7 1.0
O4 A:SIN1351 2.1 52.5 1.0
NE2 A:HIS199 2.2 73.7 1.0
NE2 A:HIS279 2.4 63.7 1.0
O3 A:SIN1351 2.6 54.6 1.0
C4 A:SIN1351 2.7 52.7 1.0
O2 A:SO41354 2.8 0.1 1.0
CG A:ASP201 3.0 58.3 1.0
CE1 A:HIS199 3.1 68.7 1.0
CD2 A:HIS279 3.2 61.1 1.0
OD1 A:ASP201 3.2 58.9 1.0
CD2 A:HIS199 3.3 60.8 1.0
CE1 A:HIS279 3.4 61.8 1.0
C3 A:SIN1351 4.2 47.3 1.0
S A:SO41354 4.2 0.9 1.0
ND1 A:HIS199 4.2 69.3 1.0
O A:HOH2029 4.2 51.7 1.0
CZ2 A:TRP296 4.4 79.1 1.0
CG A:HIS199 4.4 68.0 1.0
CG A:HIS279 4.4 66.9 1.0
CB A:ASP201 4.4 60.8 1.0
ND1 A:HIS279 4.5 68.2 1.0
O4 A:SO41354 4.8 0.1 1.0
O1 A:SO41354 4.8 0.1 1.0
C2 A:SIN1351 4.8 49.9 1.0

Reference:

K.Hewitson, B.Lienard, M.A.Mcdonough, I.J.Clifton, D.Butler, A.S.Soares, N.J.Oldham, L.A.Mcneill, C.J.Schofield. Structural and Mechanistic Studies on the Inhibition of the Hypoxia-Inducible Transcription Factor Hydroxylases By Tricarboxylic Acid Cycle Intermediates. J.Biol.Chem. V. 282 3293 2007.
ISSN: ISSN 0021-9258
PubMed: 17135241
DOI: 10.1074/JBC.M608337200
Page generated: Sat Aug 3 20:14:48 2024

Last articles

Zn in 9JPJ
Zn in 9JP7
Zn in 9JPK
Zn in 9JPL
Zn in 9GN6
Zn in 9GN7
Zn in 9GKU
Zn in 9GKW
Zn in 9GKX
Zn in 9GL0
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy