Iron in PDB 2cgo: Factor Inhibiting Hif-1 Alpha with Fumarate

All present enzymatic activity of Factor Inhibiting Hif-1 Alpha with Fumarate:
1.14.11.16;

The structure of Factor Inhibiting Hif-1 Alpha with Fumarate, PDB code: 2cgo was solved by M.A.Mcdonough, I.J.Clifton, C.J.Schofield, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	74.74 / 2.30
Space group	P 41 21 2
Cell size a, b, c (Å), α, β, γ (°)	86.660, 86.660, 147.349, 90.00, 90.00, 90.00
R / Rfree (%)	18.7 / 23.7

The binding sites of Iron atom in the Factor Inhibiting Hif-1 Alpha with Fumarate (pdb code 2cgo). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total only one binding site of Iron was determined in the Factor Inhibiting Hif-1 Alpha with Fumarate, PDB code: 2cgo:

Iron binding site 1 out of 1 in the Factor Inhibiting Hif-1 Alpha with Fumarate


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Factor Inhibiting Hif-1 Alpha with Fumarate within 5.0Å range: probe atom residue distance (Å) B Occ A:Fe350 b:46.2 occ:1.00 OD2 A:ASP201 1.9 34.4 1.0 O A:HOH2119 2.1 51.5 1.0 O1 A:FUM351 2.2 45.3 1.0 NE2 A:HIS279 2.3 36.0 1.0 NE2 A:HIS199 2.3 44.8 1.0 O3 A:FUM351 2.8 44.0 1.0 C2 A:FUM351 2.8 43.7 1.0 CG A:ASP201 3.0 32.7 1.0 CD2 A:HIS279 3.1 40.4 1.0 CE1 A:HIS199 3.2 40.7 1.0 CD2 A:HIS199 3.3 42.1 1.0 CE1 A:HIS279 3.3 37.2 1.0 OD1 A:ASP201 3.3 32.2 1.0 O2 A:SO41354 3.7 62.3 0.5 O4 A:SO41354 4.1 67.5 0.5 O A:HOH2061 4.2 43.3 1.0 C4 A:FUM351 4.3 39.3 1.0 CG A:HIS279 4.3 38.8 1.0 ND1 A:HIS199 4.3 40.2 1.0 ND1 A:HIS279 4.3 36.6 1.0 CZ2 A:TRP296 4.4 67.5 1.0 CG A:HIS199 4.4 40.9 1.0 CB A:ASP201 4.5 32.5 1.0 S A:SO41354 4.5 65.3 0.5 O4 A:SO41354 4.8 59.8 0.5 C5 A:FUM351 5.0 40.6 1.0

K.Hewitson, B.Lienard, M.A.Mcdonough, I.J.Clifton, D.Butler, A.S.Soares, N.J.Oldham, L.A.Mcneill, C.J.Schofield. Structural and Mechanistic Studies on the Inhibition of the Hypoxia-Inducible Transcription Factor Hydroxylases By Tricarboxylic Acid Cycle Intermediates. J.Biol.Chem. V. 282 3293 2007.
ISSN: ISSN 0021-9258
PubMed: 17135241
DOI: 10.1074/JBC.M608337200