Iron in PDB 2g19: Cellular Oxygen Sensing: Crystal Structure of Hypoxia-Inducible Factor Prolyl Hydroxylase (PHD2)

The structure of Cellular Oxygen Sensing: Crystal Structure of Hypoxia-Inducible Factor Prolyl Hydroxylase (PHD2), PDB code: 2g19 was solved by R.S.Syed, V.Li, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	48.00 / 1.70
Space group	P 63
Cell size a, b, c (Å), α, β, γ (°)	110.851, 110.851, 40.379, 90.00, 90.00, 120.00
R / Rfree (%)	n/a / n/a

The structure of Cellular Oxygen Sensing: Crystal Structure of Hypoxia-Inducible Factor Prolyl Hydroxylase (PHD2) also contains other interesting chemical elements:

Iodine

(I)

1 atom

The binding sites of Iron atom in the Cellular Oxygen Sensing: Crystal Structure of Hypoxia-Inducible Factor Prolyl Hydroxylase (PHD2) (pdb code 2g19). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total only one binding site of Iron was determined in the Cellular Oxygen Sensing: Crystal Structure of Hypoxia-Inducible Factor Prolyl Hydroxylase (PHD2), PDB code: 2g19:

Iron binding site 1 out of 1 in the Cellular Oxygen Sensing: Crystal Structure of Hypoxia-Inducible Factor Prolyl Hydroxylase (PHD2)


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Cellular Oxygen Sensing: Crystal Structure of Hypoxia-Inducible Factor Prolyl Hydroxylase (PHD2) within 5.0Å range: probe atom residue distance (Å) B Occ A:Fe501 b:15.9 occ:1.00 O A:HOH601 2.1 16.4 1.0 O3 A:4HG801 2.2 21.4 1.0 OD1 A:ASP315 2.2 18.4 1.0 NE2 A:HIS313 2.2 15.9 1.0 NE2 A:HIS374 2.2 16.6 1.0 N1 A:4HG801 2.2 19.4 1.0 C10 A:4HG801 2.9 19.3 1.0 CE1 A:HIS313 3.0 18.0 1.0 C8 A:4HG801 3.0 19.4 1.0 CE1 A:HIS374 3.1 18.6 1.0 CG A:ASP315 3.2 19.0 1.0 CD2 A:HIS374 3.2 18.7 1.0 CD2 A:HIS313 3.3 17.6 1.0 C7 A:4HG801 3.3 24.7 1.0 OD2 A:ASP315 3.4 15.4 1.0 N2 A:4HG801 4.2 17.7 1.0 ND1 A:HIS313 4.2 17.1 1.0 O A:HOH604 4.2 19.3 1.0 ND1 A:HIS374 4.2 17.8 1.0 CG A:HIS374 4.3 19.0 1.0 CG A:HIS313 4.3 17.0 1.0 C9 A:4HG801 4.4 22.2 1.0 CB A:ASP315 4.5 17.8 1.0 C6 A:4HG801 4.6 29.8 1.0 C11 A:4HG801 4.7 17.8 1.0 CZ A:PHE366 4.7 14.6 1.0 CA A:ASP315 4.9 18.2 1.0 N A:ASP315 5.0 17.5 1.0

M.A.Mcdonough, V.Li, E.Flashman, R.Chowdhury, C.Mohr, B.M.Lienard, J.Zondlo, N.J.Oldham, I.J.Clifton, J.Lewis, L.A.Mcneill, R.J.Kurzeja, K.S.Hewitson, E.Yang, S.Jordan, R.S.Syed, C.J.Schofield. Cellular Oxygen Sensing: Crystal Structure of Hypoxia-Inducible Factor Prolyl Hydroxylase (PHD2). Proc.Natl.Acad.Sci.Usa V. 103 9814 2006.
ISSN: ISSN 0027-8424
PubMed: 16782814
DOI: 10.1073/PNAS.0601283103