Atomistry » Iron » PDB 2grz-2hk6 » 2hi4
Atomistry »
  Iron »
    PDB 2grz-2hk6 »
      2hi4 »

Iron in PDB 2hi4: Crystal Structure of Human Microsomal P450 1A2 in Complex with Alpha- Naphthoflavone

Enzymatic activity of Crystal Structure of Human Microsomal P450 1A2 in Complex with Alpha- Naphthoflavone

All present enzymatic activity of Crystal Structure of Human Microsomal P450 1A2 in Complex with Alpha- Naphthoflavone:
1.14.14.1;

Protein crystallography data

The structure of Crystal Structure of Human Microsomal P450 1A2 in Complex with Alpha- Naphthoflavone, PDB code: 2hi4 was solved by S.Sansen, J.K.Yano, R.L.Reynald, G.S.Schoch, C.D.Stout, E.F.Johnson, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 29.51 / 1.95
Space group I 2 2 2
Cell size a, b, c (Å), α, β, γ (°) 79.630, 80.820, 175.820, 90.00, 90.00, 90.00
R / Rfree (%) 22.6 / 26.7

Iron Binding Sites:

The binding sites of Iron atom in the Crystal Structure of Human Microsomal P450 1A2 in Complex with Alpha- Naphthoflavone (pdb code 2hi4). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total only one binding site of Iron was determined in the Crystal Structure of Human Microsomal P450 1A2 in Complex with Alpha- Naphthoflavone, PDB code: 2hi4:

Iron binding site 1 out of 1 in 2hi4

Go back to Iron Binding Sites List in 2hi4
Iron binding site 1 out of 1 in the Crystal Structure of Human Microsomal P450 1A2 in Complex with Alpha- Naphthoflavone


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Crystal Structure of Human Microsomal P450 1A2 in Complex with Alpha- Naphthoflavone within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Fe900

b:22.4
occ:1.00
FE A:HEM900 0.0 22.4 1.0
NA A:HEM900 2.1 15.1 1.0
NC A:HEM900 2.1 22.3 1.0
ND A:HEM900 2.1 25.1 1.0
NB A:HEM900 2.1 21.5 1.0
SG A:CYS458 2.3 25.0 1.0
C1D A:HEM900 3.0 26.0 1.0
C4C A:HEM900 3.0 21.5 1.0
C4A A:HEM900 3.0 30.1 1.0
C1B A:HEM900 3.1 23.8 1.0
C1C A:HEM900 3.1 20.6 1.0
C4B A:HEM900 3.1 20.7 1.0
C4D A:HEM900 3.1 20.9 1.0
C1A A:HEM900 3.1 18.1 1.0
CHD A:HEM900 3.2 21.7 1.0
CB A:CYS458 3.2 21.0 1.0
CHB A:HEM900 3.3 25.3 1.0
CHC A:HEM900 3.4 21.3 1.0
CHA A:HEM900 3.5 16.5 1.0
CA A:CYS458 4.0 23.4 1.0
C3C A:HEM900 4.2 20.0 1.0
C2C A:HEM900 4.2 27.0 1.0
C2D A:HEM900 4.2 27.0 1.0
C3A A:HEM900 4.3 21.4 1.0
C2B A:HEM900 4.3 21.4 1.0
C3D A:HEM900 4.3 22.4 1.0
C2A A:HEM900 4.3 24.2 1.0
C3B A:HEM900 4.4 22.3 1.0
C A:CYS458 4.7 26.1 1.0
C4 A:BHF800 4.7 31.9 1.0
N A:ILE459 4.8 27.9 1.0
CG2 A:THR321 4.8 19.4 1.0
N A:GLY460 4.8 25.1 1.0
CB A:ALA317 4.9 21.8 1.0
C5 A:BHF800 5.0 32.8 1.0

Reference:

S.Sansen, J.K.Yano, R.L.Reynald, G.A.Schoch, K.J.Griffin, C.D.Stout, E.F.Johnson. Adaptations For the Oxidation of Polycyclic Aromatic Hydrocarbons Exhibited By the Structure of Human P450 1A2. J.Biol.Chem. V. 282 14348 2007.
ISSN: ISSN 0021-9258
PubMed: 17311915
DOI: 10.1074/JBC.M611692200
Page generated: Sun Dec 13 14:46:11 2020

Last articles

Zn in 8WB0
Zn in 8WAX
Zn in 8WAU
Zn in 8WAZ
Zn in 8WAY
Zn in 8WAV
Zn in 8WAW
Zn in 8WAT
Zn in 8W7M
Zn in 8WD3
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy