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Iron in PDB 2ij7: Structure of Mycobacterium Tuberculosis CYP121 in Complex with the Antifungal Drug Fluconazole
Protein crystallography data
The structure of Structure of Mycobacterium Tuberculosis CYP121 in Complex with the Antifungal Drug Fluconazole, PDB code: 2ij7
was solved by
A.Roujeinikova,
D.Leys,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 20.00 / 1.90 |
| Space group | P 21 21 21 |
| Cell size a, b, c (Å), α, β, γ (°) | 60.805, 129.898, 323.393, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 16.7 / 22.6 |
Other elements in 2ij7:
The structure of Structure of Mycobacterium Tuberculosis CYP121 in Complex with the Antifungal Drug Fluconazole also contains other interesting chemical elements:
| Fluorine | (F) | 16 atoms |
Iron Binding Sites:
The binding sites of Iron atom in the Structure of Mycobacterium Tuberculosis CYP121 in Complex with the Antifungal Drug Fluconazole
(pdb code 2ij7). This binding sites where shown within
5.0 Angstroms radius around Iron atom.
In total 6 binding sites of Iron where determined in the Structure of Mycobacterium Tuberculosis CYP121 in Complex with the Antifungal Drug Fluconazole, PDB code: 2ij7:
Jump to Iron binding site number: 1; 2; 3; 4; 5; 6;
In total 6 binding sites of Iron where determined in the Structure of Mycobacterium Tuberculosis CYP121 in Complex with the Antifungal Drug Fluconazole, PDB code: 2ij7:
Jump to Iron binding site number: 1; 2; 3; 4; 5; 6;
Iron binding site 1 out of 6 in 2ij7
Go back to
Iron Binding Sites List in 2ij7
Iron binding site 1 out
of 6 in the Structure of Mycobacterium Tuberculosis CYP121 in Complex with the Antifungal Drug Fluconazole
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Iron with other atoms in the Fe binding
site number 1 of Structure of Mycobacterium Tuberculosis CYP121 in Complex with the Antifungal Drug Fluconazole within 5.0Å range:
|
Iron binding site 2 out of 6 in 2ij7
Go back to
Iron Binding Sites List in 2ij7
Iron binding site 2 out
of 6 in the Structure of Mycobacterium Tuberculosis CYP121 in Complex with the Antifungal Drug Fluconazole
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Iron with other atoms in the Fe binding
site number 2 of Structure of Mycobacterium Tuberculosis CYP121 in Complex with the Antifungal Drug Fluconazole within 5.0Å range:
|
Iron binding site 3 out of 6 in 2ij7
Go back to
Iron Binding Sites List in 2ij7
Iron binding site 3 out
of 6 in the Structure of Mycobacterium Tuberculosis CYP121 in Complex with the Antifungal Drug Fluconazole
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Iron with other atoms in the Fe binding
site number 3 of Structure of Mycobacterium Tuberculosis CYP121 in Complex with the Antifungal Drug Fluconazole within 5.0Å range:
|
Iron binding site 4 out of 6 in 2ij7
Go back to
Iron Binding Sites List in 2ij7
Iron binding site 4 out
of 6 in the Structure of Mycobacterium Tuberculosis CYP121 in Complex with the Antifungal Drug Fluconazole
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Iron with other atoms in the Fe binding
site number 4 of Structure of Mycobacterium Tuberculosis CYP121 in Complex with the Antifungal Drug Fluconazole within 5.0Å range:
|
Iron binding site 5 out of 6 in 2ij7
Go back to
Iron Binding Sites List in 2ij7
Iron binding site 5 out
of 6 in the Structure of Mycobacterium Tuberculosis CYP121 in Complex with the Antifungal Drug Fluconazole
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Iron with other atoms in the Fe binding
site number 5 of Structure of Mycobacterium Tuberculosis CYP121 in Complex with the Antifungal Drug Fluconazole within 5.0Å range:
|
Iron binding site 6 out of 6 in 2ij7
Go back to
Iron Binding Sites List in 2ij7
Iron binding site 6 out
of 6 in the Structure of Mycobacterium Tuberculosis CYP121 in Complex with the Antifungal Drug Fluconazole
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Iron with other atoms in the Fe binding
site number 6 of Structure of Mycobacterium Tuberculosis CYP121 in Complex with the Antifungal Drug Fluconazole within 5.0Å range:
|
Reference:
H.E.Seward,
A.Roujeinikova,
K.J.Mclean,
A.W.Munro,
D.Leys.
Crystal Structure of the Mycobacterium Tuberculosis P450 CYP121-Fluconazole Complex Reveals New Azole Drug-P450 Binding Mode. J.Biol.Chem. V. 281 39437 2006.
ISSN: ISSN 0021-9258
PubMed: 17028183
DOI: 10.1074/JBC.M607665200
Page generated: Sat Aug 3 23:21:49 2024
ISSN: ISSN 0021-9258
PubMed: 17028183
DOI: 10.1074/JBC.M607665200
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