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Atomistry » Iron » PDB 2orl-2pg7 » 2ors » |
Iron in PDB 2ors: Murine Inducible Nitric Oxide Synthase Oxygenase Domain (Delta 114) 4-(Benzo[1,3]Dioxol-5-Yloxy)-2-(4-Imidazol-1- Yl-Phenoxy)-6-Methyl-Pyrimidine ComplexEnzymatic activity of Murine Inducible Nitric Oxide Synthase Oxygenase Domain (Delta 114) 4-(Benzo[1,3]Dioxol-5-Yloxy)-2-(4-Imidazol-1- Yl-Phenoxy)-6-Methyl-Pyrimidine Complex
All present enzymatic activity of Murine Inducible Nitric Oxide Synthase Oxygenase Domain (Delta 114) 4-(Benzo[1,3]Dioxol-5-Yloxy)-2-(4-Imidazol-1- Yl-Phenoxy)-6-Methyl-Pyrimidine Complex:
1.14.13.39; Protein crystallography data
The structure of Murine Inducible Nitric Oxide Synthase Oxygenase Domain (Delta 114) 4-(Benzo[1,3]Dioxol-5-Yloxy)-2-(4-Imidazol-1- Yl-Phenoxy)-6-Methyl-Pyrimidine Complex, PDB code: 2ors
was solved by
M.Adler,
M.Whitlow,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Iron Binding Sites:
The binding sites of Iron atom in the Murine Inducible Nitric Oxide Synthase Oxygenase Domain (Delta 114) 4-(Benzo[1,3]Dioxol-5-Yloxy)-2-(4-Imidazol-1- Yl-Phenoxy)-6-Methyl-Pyrimidine Complex
(pdb code 2ors). This binding sites where shown within
5.0 Angstroms radius around Iron atom.
In total only one binding site of Iron was determined in the Murine Inducible Nitric Oxide Synthase Oxygenase Domain (Delta 114) 4-(Benzo[1,3]Dioxol-5-Yloxy)-2-(4-Imidazol-1- Yl-Phenoxy)-6-Methyl-Pyrimidine Complex, PDB code: 2ors: Iron binding site 1 out of 1 in 2orsGo back to![]() ![]()
Iron binding site 1 out
of 1 in the Murine Inducible Nitric Oxide Synthase Oxygenase Domain (Delta 114) 4-(Benzo[1,3]Dioxol-5-Yloxy)-2-(4-Imidazol-1- Yl-Phenoxy)-6-Methyl-Pyrimidine Complex
![]() Mono view ![]() Stereo pair view
Reference:
D.D.Davey,
M.Adler,
D.Arnaia,
K.Eagen,
S.Erickson,
W.Guilford,
M.Kenrick,
M.M.Morrissey,
M.Ohimeyer,
G.Pan,
V.M.Paradkar,
J.Parkinson,
M.Polokoff,
K.Salonz,
C.Santos,
B.Subramanyam,
R.Vergona,
R.G.Wei,
M.Whitlow,
B.Ye,
Z.S.Zhao,
J.J.Devlin,
G.Phillips.
Design, Synthesis, and Activity of 2-Imidazol-1-Ylpyrimidine Derived Inducible Nitric Oxide Synthase Dimerization Inhibitors J.Med.Chem. V. 50 1146 2007.
Page generated: Thu Jul 17 03:16:34 2025
ISSN: ISSN 0022-2623 PubMed: 17315988 DOI: 10.1021/JM061319I |
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