Atomistry » Iron » PDB 2orl-2pg7 » 2oye
Atomistry »
  Iron »
    PDB 2orl-2pg7 »
      2oye »

Iron in PDB 2oye: Indomethacin-(R)-Alpha-Ethyl-Ethanolamide Bound to Cyclooxygenase-1

Enzymatic activity of Indomethacin-(R)-Alpha-Ethyl-Ethanolamide Bound to Cyclooxygenase-1

All present enzymatic activity of Indomethacin-(R)-Alpha-Ethyl-Ethanolamide Bound to Cyclooxygenase-1:
1.14.99.1;

Protein crystallography data

The structure of Indomethacin-(R)-Alpha-Ethyl-Ethanolamide Bound to Cyclooxygenase-1, PDB code: 2oye was solved by C.A.Harman, R.M.Garavito, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 30.00 / 2.85
Space group P 65 2 2
Cell size a, b, c (Å), α, β, γ (°) 181.720, 181.720, 104.090, 90.00, 90.00, 120.00
R / Rfree (%) 24.5 / 29.2

Other elements in 2oye:

The structure of Indomethacin-(R)-Alpha-Ethyl-Ethanolamide Bound to Cyclooxygenase-1 also contains other interesting chemical elements:

Chlorine (Cl) 1 atom

Iron Binding Sites:

The binding sites of Iron atom in the Indomethacin-(R)-Alpha-Ethyl-Ethanolamide Bound to Cyclooxygenase-1 (pdb code 2oye). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total only one binding site of Iron was determined in the Indomethacin-(R)-Alpha-Ethyl-Ethanolamide Bound to Cyclooxygenase-1, PDB code: 2oye:

Iron binding site 1 out of 1 in 2oye

Go back to Iron Binding Sites List in 2oye
Iron binding site 1 out of 1 in the Indomethacin-(R)-Alpha-Ethyl-Ethanolamide Bound to Cyclooxygenase-1


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Indomethacin-(R)-Alpha-Ethyl-Ethanolamide Bound to Cyclooxygenase-1 within 5.0Å range:
probe atom residue distance (Å) B Occ
P:Fe601

b:73.2
occ:1.00
 FE P:HEM601 0.0 73.2 1.0
ND P:HEM601 1.9 73.2 1.0
NB P:HEM601 1.9 73.2 1.0
NA P:HEM601 2.0 73.2 1.0
NE2 P:HIS388 2.0 57.3 1.0
NC P:HEM601 2.0 73.2 1.0
C4D P:HEM601 3.0 73.2 1.0
C4B P:HEM601 3.0 73.2 1.0
C1D P:HEM601 3.0 73.2 1.0
CD2 P:HIS388 3.0 57.3 1.0
C1C P:HEM601 3.0 73.2 1.0
CE1 P:HIS388 3.0 57.3 1.0
C1A P:HEM601 3.0 73.2 1.0
C4A P:HEM601 3.1 73.2 1.0
C1B P:HEM601 3.1 73.2 1.0
C4C P:HEM601 3.1 73.2 1.0
CHA P:HEM601 3.3 73.2 1.0
CHC P:HEM601 3.4 73.2 1.0
CHB P:HEM601 3.4 73.2 1.0
CHD P:HEM601 3.4 73.2 1.0
OE1 P:GLN203 4.1 69.4 1.0
ND1 P:HIS388 4.2 57.3 1.0
CG P:HIS388 4.2 57.3 1.0
C3D P:HEM601 4.2 73.2 1.0
C3B P:HEM601 4.3 73.2 1.0
C2C P:HEM601 4.3 73.2 1.0
C2D P:HEM601 4.3 73.2 1.0
C3C P:HEM601 4.3 73.2 1.0
C2B P:HEM601 4.3 73.2 1.0
C2A P:HEM601 4.4 73.2 1.0
C3A P:HEM601 4.4 73.2 1.0
CE1 P:HIS207 4.5 76.5 1.0
CG1 P:VAL447 4.6 45.0 1.0
NE2 P:HIS207 4.7 76.5 1.0
CD P:GLN203 4.8 69.4 1.0

Reference:

C.A.Harman, M.V.Turman, K.R.Kozak, L.J.Marnett, W.L.Smith, R.M.Garavito. Structural Basis of Enantioselective Inhibition of Cyclooxygenase-1 By S-Alpha-Substituted Indomethacin Ethanolamides. J.Biol.Chem. V. 282 28096 2007.
ISSN: ISSN 0021-9258
PubMed: 17656360
DOI: 10.1074/JBC.M701335200
Page generated: Sun Aug 4 01:08:35 2024

Last articles

Zn in 9JPJ
Zn in 9JP7
Zn in 9JPK
Zn in 9JPL
Zn in 9GN6
Zn in 9GN7
Zn in 9GKU
Zn in 9GKW
Zn in 9GKX
Zn in 9GL0
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy