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Iron in PDB 2qpp: Crystal Structure of Human Heme Oxygenase-2 C127A (Ho-2) with Bound Heme

Enzymatic activity of Crystal Structure of Human Heme Oxygenase-2 C127A (Ho-2) with Bound Heme

All present enzymatic activity of Crystal Structure of Human Heme Oxygenase-2 C127A (Ho-2) with Bound Heme:
1.14.99.3;

Protein crystallography data

The structure of Crystal Structure of Human Heme Oxygenase-2 C127A (Ho-2) with Bound Heme, PDB code: 2qpp was solved by C.M.Bianchetti, C.A.Bingman, E.Bitto, G.E.Wesenberg, G.N.Phillips Jr., Center For Eukaryotic Structural Genomics (Cesg), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 40.96 / 2.61
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 74.977, 85.094, 97.846, 90.00, 90.00, 90.00
R / Rfree (%) 20.2 / 25.6

Iron Binding Sites:

The binding sites of Iron atom in the Crystal Structure of Human Heme Oxygenase-2 C127A (Ho-2) with Bound Heme (pdb code 2qpp). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total 2 binding sites of Iron where determined in the Crystal Structure of Human Heme Oxygenase-2 C127A (Ho-2) with Bound Heme, PDB code: 2qpp:
Jump to Iron binding site number: 1; 2;

Iron binding site 1 out of 2 in 2qpp

Go back to Iron Binding Sites List in 2qpp
Iron binding site 1 out of 2 in the Crystal Structure of Human Heme Oxygenase-2 C127A (Ho-2) with Bound Heme


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Crystal Structure of Human Heme Oxygenase-2 C127A (Ho-2) with Bound Heme within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Fe300

b:56.9
occ:1.00
FE A:HEM300 0.0 56.9 1.0
NC A:HEM300 2.0 58.0 1.0
ND A:HEM300 2.1 56.8 1.0
NE2 A:HIS45 2.1 63.4 1.0
NA A:HEM300 2.1 58.6 1.0
NB A:HEM300 2.1 58.6 1.0
O A:HOH319 2.4 78.3 1.0
CE1 A:HIS45 2.9 64.0 1.0
C4C A:HEM300 3.0 57.4 1.0
C1D A:HEM300 3.1 56.1 1.0
C4D A:HEM300 3.1 56.8 1.0
C1B A:HEM300 3.1 58.9 1.0
C4A A:HEM300 3.1 59.7 1.0
C1C A:HEM300 3.1 58.3 1.0
C1A A:HEM300 3.1 59.7 1.0
C4B A:HEM300 3.1 58.6 1.0
CD2 A:HIS45 3.2 63.4 1.0
CHD A:HEM300 3.4 57.0 1.0
CHA A:HEM300 3.4 58.6 1.0
CHB A:HEM300 3.4 59.7 1.0
CHC A:HEM300 3.5 58.4 1.0
ND1 A:HIS45 4.1 63.4 1.0
CG A:HIS45 4.2 63.0 1.0
C3C A:HEM300 4.3 57.7 1.0
C3D A:HEM300 4.3 56.0 1.0
C2D A:HEM300 4.3 55.7 1.0
C2C A:HEM300 4.3 57.7 1.0
C3A A:HEM300 4.3 61.0 1.0
C2B A:HEM300 4.3 59.6 1.0
C2A A:HEM300 4.3 61.1 1.0
C3B A:HEM300 4.3 59.2 1.0
CA A:GLY159 4.6 55.4 1.0

Iron binding site 2 out of 2 in 2qpp

Go back to Iron Binding Sites List in 2qpp
Iron binding site 2 out of 2 in the Crystal Structure of Human Heme Oxygenase-2 C127A (Ho-2) with Bound Heme


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 2 of Crystal Structure of Human Heme Oxygenase-2 C127A (Ho-2) with Bound Heme within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Fe300

b:79.3
occ:0.75
FE B:HEM300 0.0 79.3 0.8
NB B:HEM300 2.0 80.0 0.8
NC B:HEM300 2.1 79.8 0.8
ND B:HEM300 2.1 79.7 0.8
NA B:HEM300 2.1 80.0 0.8
NE2 B:HIS45 2.4 84.3 1.0
C4B B:HEM300 3.1 80.0 0.8
C4C B:HEM300 3.1 79.6 0.8
C1C B:HEM300 3.1 79.6 0.8
C1B B:HEM300 3.1 80.3 0.8
C1D B:HEM300 3.1 79.4 0.8
C4D B:HEM300 3.1 79.4 0.8
C4A B:HEM300 3.1 80.1 0.8
C1A B:HEM300 3.1 79.9 0.8
CE1 B:HIS45 3.2 84.3 1.0
CHC B:HEM300 3.4 79.9 0.8
CHD B:HEM300 3.4 79.4 0.8
CHA B:HEM300 3.5 79.7 0.8
CHB B:HEM300 3.5 80.2 0.8
CD2 B:HIS45 3.5 84.3 1.0
C3B B:HEM300 4.3 80.2 0.8
C3C B:HEM300 4.3 79.5 0.8
C2B B:HEM300 4.3 80.5 0.8
C2C B:HEM300 4.3 79.8 0.8
C3D B:HEM300 4.3 79.4 0.8
C2D B:HEM300 4.3 79.2 0.8
C3A B:HEM300 4.3 80.2 0.8
ND1 B:HIS45 4.3 84.3 1.0
C2A B:HEM300 4.4 80.1 0.8
CG B:HIS45 4.5 84.2 1.0
CA B:GLY159 4.6 70.6 1.0
O B:HOH324 4.8 63.8 1.0

Reference:

C.M.Bianchetti, L.Yi, S.W.Ragsdale, G.N.Phillips Jr.. Comparison of Apo- and Heme-Bound Crystal Structures of A Truncated Human Heme Oxygenase-2. J.Biol.Chem. V. 282 37624 2007.
ISSN: ISSN 0021-9258
PubMed: 17965015
DOI: 10.1074/JBC.M707396200
Page generated: Sun Dec 13 14:52:11 2020

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