Iron in PDB 2uw2: Crystal Structure of Human Ribonucleotide Reductase Subunit R2

All present enzymatic activity of Crystal Structure of Human Ribonucleotide Reductase Subunit R2:
1.17.4.1;

The structure of Crystal Structure of Human Ribonucleotide Reductase Subunit R2, PDB code: 2uw2 was solved by M.Welin, D.Ogg, C.Arrowsmith, H.Berglund, R.Busam, R.Collins, A.Edwards, M.Ehn, S.Flodin, A.Flores, S.Graslund, M.Hammarstrom, B.M.Hallberg, L.Holmberg Schiavone, M.Hogbom, T.Kotenyova, A.Magnusdottir, M.Moche, P.Nilsson-Ehle, T.Nyman, C.Persson, J.Sagemark, M.Sundstrom, P.Stenmark, J.Uppenberg, A.G.Thorsell, S.Van Den Berg, K.Wallden, J.Weigelt, P.Nordlund, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	19.12 / 2.8
Space group	C 2 2 21
Cell size a, b, c (Å), α, β, γ (°)	76.120, 110.700, 94.420, 90.00, 90.00, 90.00
R / Rfree (%)	23 / 29.4

The binding sites of Iron atom in the Crystal Structure of Human Ribonucleotide Reductase Subunit R2 (pdb code 2uw2). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total only one binding site of Iron was determined in the Crystal Structure of Human Ribonucleotide Reductase Subunit R2, PDB code: 2uw2:

Iron binding site 1 out of 1 in the Crystal Structure of Human Ribonucleotide Reductase Subunit R2


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Crystal Structure of Human Ribonucleotide Reductase Subunit R2 within 5.0Å range: probe atom residue distance (Å) B Occ A:Fe1351 b:60.2 occ:1.00 OE2 A:GLU266 2.1 51.1 1.0 OE1 A:GLU169 2.3 54.2 1.0 ND1 A:HIS269 2.4 44.0 1.0 CD A:GLU266 2.7 48.1 1.0 OE2 A:GLU169 2.8 56.7 1.0 OE1 A:GLU266 2.8 50.7 1.0 CD A:GLU169 2.9 51.5 1.0 OE2 A:GLU232 3.0 61.6 1.0 O A:HOH2004 3.0 44.6 1.0 CE1 A:HIS269 3.2 44.4 1.0 CD A:GLU232 3.4 60.9 1.0 CG A:HIS269 3.5 44.3 1.0 CG A:GLU232 3.7 60.6 1.0 CB A:HIS269 3.9 43.3 1.0 CG A:GLU266 4.1 47.2 1.0 CG1 A:VAL141 4.2 84.1 1.0 OE1 A:GLU232 4.2 64.4 1.0 CB A:GLU232 4.4 59.6 1.0 CG A:GLU169 4.4 46.4 1.0 NE2 A:HIS269 4.4 44.0 1.0 CA A:GLU266 4.4 44.9 1.0 NE2 A:GLN165 4.4 33.2 1.0 CD2 A:HIS269 4.6 43.9 1.0 OD1 A:ASP138 4.6 83.6 1.0 CB A:GLU266 4.6 45.0 1.0 CE1 A:HIS172 4.7 38.5 1.0 ND1 A:HIS172 4.7 40.2 1.0 N A:GLU266 5.0 45.1 1.0 CG A:GLN165 5.0 37.0 1.0

M.Welin, D.Ogg, C.Arrowsmith, H.Berglund, R.Busam, R.Collins, A.Edwards, M.Ehn, S.Flodin, A.Flores, S.Graslund, M.Hammarstrom, B.M.Hallberg, L.Holmberg Schiavone, M.Hogbom, T.Kotenyova, A.Magnusdottir, M.Moche, P.Nilsson-Ehle, T.Nyman, C.Persson, J.Sagemark, M.Sundstrom, P.Stenmark, J.Uppenberg, A.G.Thorsell, S.Van Den Berg, K.Wallden, J.Weigelt, P.Nordlund. Crystal Structure of Human Ribonucleotide Reductase Subunit R2 To Be Published.