Iron in PDB 2v2e: Structure of Isoniazid (Inh) Bound to Cytochrome C Peroxidase Mutant N184R Y36A

All present enzymatic activity of Structure of Isoniazid (Inh) Bound to Cytochrome C Peroxidase Mutant N184R Y36A:
1.11.1.5;

The structure of Structure of Isoniazid (Inh) Bound to Cytochrome C Peroxidase Mutant N184R Y36A, PDB code: 2v2e was solved by C.L.Metcalfe, I.K.Macdonald, K.A.Brown, E.L.Raven, P.C.E.Moody, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	30.28 / 1.68
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	51.147, 75.130, 106.864, 90.00, 90.00, 90.00
R / Rfree (%)	16.5 / 18.7

The binding sites of Iron atom in the Structure of Isoniazid (Inh) Bound to Cytochrome C Peroxidase Mutant N184R Y36A (pdb code 2v2e). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total only one binding site of Iron was determined in the Structure of Isoniazid (Inh) Bound to Cytochrome C Peroxidase Mutant N184R Y36A, PDB code: 2v2e:

Iron binding site 1 out of 1 in the Structure of Isoniazid (Inh) Bound to Cytochrome C Peroxidase Mutant N184R Y36A


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Structure of Isoniazid (Inh) Bound to Cytochrome C Peroxidase Mutant N184R Y36A within 5.0Å range: probe atom residue distance (Å) B Occ A:Fe1295 b:10.5 occ:1.00 FE A:HEM1295 0.0 10.5 1.0 NA A:HEM1295 2.0 9.4 1.0 NC A:HEM1295 2.1 8.6 1.0 NB A:HEM1295 2.1 9.0 1.0 ND A:HEM1295 2.1 9.6 1.0 NE2 A:HIS175 2.1 9.4 1.0 O A:HOH2063 2.9 14.1 1.0 C1A A:HEM1295 3.1 9.1 1.0 C4A A:HEM1295 3.1 8.9 1.0 C1C A:HEM1295 3.1 8.0 1.0 C1B A:HEM1295 3.1 9.2 1.0 C4C A:HEM1295 3.1 8.3 1.0 C4D A:HEM1295 3.1 9.0 1.0 CD2 A:HIS175 3.1 9.8 1.0 C4B A:HEM1295 3.1 9.6 1.0 C1D A:HEM1295 3.1 9.0 1.0 CE1 A:HIS175 3.1 9.5 1.0 CHA A:HEM1295 3.4 9.3 1.0 CHC A:HEM1295 3.4 8.4 1.0 CHD A:HEM1295 3.4 8.9 1.0 CHB A:HEM1295 3.4 9.0 1.0 NE1 A:TRP51 4.0 9.9 1.0 ND1 A:HIS175 4.2 9.4 1.0 CG A:HIS175 4.3 10.0 1.0 C2A A:HEM1295 4.3 8.9 1.0 C3A A:HEM1295 4.3 8.9 1.0 C2C A:HEM1295 4.3 7.5 1.0 C3D A:HEM1295 4.3 8.9 1.0 C2B A:HEM1295 4.3 9.6 1.0 C3C A:HEM1295 4.3 8.4 1.0 C3B A:HEM1295 4.3 9.6 1.0 C2D A:HEM1295 4.3 8.2 1.0 CD1 A:TRP51 4.5 9.3 1.0 N3 A:ISZ1296 4.9 15.4 0.9 CH2 A:TRP191 5.0 10.3 1.0 O1 A:ISZ1296 5.0 14.9 0.9 NE A:ARG48 5.0 13.0 1.0

C.L.Metcalfe, I.K.Macdonald, E.J.Murphy, K.A.Brown, E.L.Raven, P.C.E.Moody. The Tuberculosis Prodrug Isoniazid Bound to Activating Peroxidases. J.Biol.Chem. V. 283 6193 2008.
ISSN: ISSN 0021-9258
PubMed: 18056997
DOI: 10.1074/JBC.M707412200