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Iron in PDB 2vcf: Structure of Isoniazid (Inh) Bound to Cytosolic Soybean Ascorbate Peroxidase

Enzymatic activity of Structure of Isoniazid (Inh) Bound to Cytosolic Soybean Ascorbate Peroxidase

All present enzymatic activity of Structure of Isoniazid (Inh) Bound to Cytosolic Soybean Ascorbate Peroxidase:
1.11.1.11;

Protein crystallography data

The structure of Structure of Isoniazid (Inh) Bound to Cytosolic Soybean Ascorbate Peroxidase, PDB code: 2vcf was solved by C.L.Metcalfe, I.K.Macdonald, K.A.Brown, E.L.Raven, P.C.E.Moody, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 26.01 / 1.80
Space group P 42 21 2
Cell size a, b, c (Å), α, β, γ (°) 82.243, 82.243, 74.965, 90.00, 90.00, 90.00
R / Rfree (%) 15.4 / 18.8

Other elements in 2vcf:

The structure of Structure of Isoniazid (Inh) Bound to Cytosolic Soybean Ascorbate Peroxidase also contains other interesting chemical elements:

Sodium (Na) 1 atom

Iron Binding Sites:

The binding sites of Iron atom in the Structure of Isoniazid (Inh) Bound to Cytosolic Soybean Ascorbate Peroxidase (pdb code 2vcf). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total only one binding site of Iron was determined in the Structure of Isoniazid (Inh) Bound to Cytosolic Soybean Ascorbate Peroxidase, PDB code: 2vcf:

Iron binding site 1 out of 1 in 2vcf

Go back to Iron Binding Sites List in 2vcf
Iron binding site 1 out of 1 in the Structure of Isoniazid (Inh) Bound to Cytosolic Soybean Ascorbate Peroxidase


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Structure of Isoniazid (Inh) Bound to Cytosolic Soybean Ascorbate Peroxidase within 5.0Å range:
probe atom residue distance (Å) B Occ
X:Fe1254

b:10.3
occ:1.00
 FE X:HEM1254 0.0 10.3 1.0
O X:HOH2084 2.0 17.3 1.0
NE2 X:HIS163 2.0 8.1 1.0
NC X:HEM1254 2.0 8.1 1.0
NB X:HEM1254 2.0 9.1 1.0
NA X:HEM1254 2.1 9.1 1.0
ND X:HEM1254 2.1 7.8 1.0
CD2 X:HIS163 2.9 7.9 1.0
C1C X:HEM1254 3.0 9.0 1.0
C4B X:HEM1254 3.0 9.7 1.0
CE1 X:HIS163 3.0 9.0 1.0
C4C X:HEM1254 3.0 8.3 1.0
C1B X:HEM1254 3.1 9.6 1.0
C1A X:HEM1254 3.1 9.0 1.0
C4A X:HEM1254 3.1 10.1 1.0
C1D X:HEM1254 3.1 7.8 1.0
C4D X:HEM1254 3.1 7.9 1.0
CHC X:HEM1254 3.4 8.6 1.0
CHD X:HEM1254 3.4 7.3 1.0
CHB X:HEM1254 3.4 8.8 1.0
CHA X:HEM1254 3.5 8.2 1.0
NE1 X:TRP41 4.0 12.3 1.0
CG X:HIS163 4.1 8.6 1.0
ND1 X:HIS163 4.1 8.9 1.0
C2C X:HEM1254 4.3 7.6 1.0
C3B X:HEM1254 4.3 10.3 1.0
C3C X:HEM1254 4.3 7.5 1.0
C2B X:HEM1254 4.3 10.2 1.0
C2A X:HEM1254 4.3 9.4 1.0
C3A X:HEM1254 4.3 9.9 1.0
O X:HOH2377 4.3 24.4 1.0
C2D X:HEM1254 4.3 8.2 1.0
C3D X:HEM1254 4.3 7.6 1.0
O X:HOH2086 4.5 28.2 1.0
CD1 X:TRP41 4.5 12.2 1.0

Reference:

C.L.Metcalfe, I.K.Macdonald, E.J.Murphy, K.A.Brown, E.L.Raven, P.C.E.Moody. The Tuberculosis Prodrug Isoniazid Bound to Activating Peroxidases. J.Biol.Chem. V. 283 6193 2008.
ISSN: ISSN 0021-9258
PubMed: 18056997
DOI: 10.1074/JBC.M707412200
Page generated: Sun Aug 4 02:35:44 2024

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