Iron in PDB 2vux: Human Ribonucleotide Reductase, Subunit M2 B

All present enzymatic activity of Human Ribonucleotide Reductase, Subunit M2 B:
1.17.4.1;

The structure of Human Ribonucleotide Reductase, Subunit M2 B, PDB code: 2vux was solved by M.Welin, M.Moche, J.Andersson, C.H.Arrowsmith, H.Berglund, R.D.Busam, R.Collins, L.G.Dahlgren, A.M.Edwards, S.Flodin, A.Flores, S.Graslund, M.Hammarstrom, M.D.Herman, A.Johansson, I.Johansson, A.Kallas, T.Karlberg, T.Kotenyova, L.Lehtio, M.E.Nilsson, T.Nyman, C.Persson, J.Sagemark, H.Schueler, L.Svensson, A.G.Thorsell, L.Tresaugues, S.Van Den Berg, J.Weigelt, M.Wikstrom, P.Nordlund, Structural Genomicsconsortium (Sgc), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	19.83 / 2.8
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	68.960, 99.470, 132.580, 90.00, 90.00, 90.00
R / Rfree (%)	20.9 / 25.8

The binding sites of Iron atom in the Human Ribonucleotide Reductase, Subunit M2 B (pdb code 2vux). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total 2 binding sites of Iron where determined in the Human Ribonucleotide Reductase, Subunit M2 B, PDB code: 2vux:
Jump to Iron binding site number: 1; 2;

Iron binding site 1 out of 2 in the Human Ribonucleotide Reductase, Subunit M2 B


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Human Ribonucleotide Reductase, Subunit M2 B within 5.0Å range: probe atom residue distance (Å) B Occ A:Fe1313 b:91.9 occ:1.00 OE2 A:GLU194 2.4 68.1 1.0 OE1 A:GLU228 2.6 64.1 1.0 ND1 A:HIS231 2.8 57.4 1.0 OE2 A:GLU131 2.9 66.5 1.0 OE1 A:GLU131 2.9 67.3 1.0 OE2 A:GLU228 2.9 65.2 1.0 CD A:GLU228 3.1 60.8 1.0 CD A:GLU131 3.1 64.3 1.0 CE1 A:HIS231 3.4 58.2 1.0 CD A:GLU194 3.5 65.2 1.0 CG A:HIS231 3.6 55.9 1.0 OE1 A:GLU194 3.8 67.1 1.0 NE2 A:GLN127 3.9 60.0 1.0 CB A:HIS231 4.1 55.4 1.0 NE2 A:HIS231 4.4 57.4 1.0 CG A:GLU131 4.5 60.2 1.0 CD2 A:HIS231 4.5 56.9 1.0 CG A:GLU228 4.6 58.0 1.0 CG A:GLN127 4.6 58.2 1.0 CA A:GLU228 4.6 55.5 1.0 CD A:GLN127 4.7 58.8 1.0 NE2 A:HIS134 4.7 54.9 1.0 CD2 A:HIS134 4.7 55.3 1.0 CG A:GLU194 4.8 62.5 1.0

Iron binding site 2 out of 2 in the Human Ribonucleotide Reductase, Subunit M2 B


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 2 of Human Ribonucleotide Reductase, Subunit M2 B within 5.0Å range: probe atom residue distance (Å) B Occ B:Fe1315 b:93.1 occ:1.00 OE2 B:GLU228 2.0 66.5 1.0 OE1 B:GLU131 2.5 57.5 1.0 OE2 B:GLU194 2.6 70.2 1.0 ND1 B:HIS231 2.8 57.2 1.0 CD B:GLU228 3.0 63.9 1.0 OE2 B:GLU131 3.0 59.3 1.0 CD B:GLU131 3.1 56.1 1.0 OE1 B:GLU228 3.3 67.1 1.0 CD B:GLU194 3.4 68.9 1.0 OE1 B:GLU194 3.6 69.6 1.0 CE1 B:HIS231 3.6 57.8 1.0 CG B:HIS231 3.8 57.3 1.0 CB B:HIS231 4.0 57.0 1.0 NE2 B:GLN127 4.3 54.5 1.0 CG B:GLU228 4.3 60.2 1.0 CG B:GLU131 4.5 53.4 1.0 CA B:GLU228 4.6 56.8 1.0 CB B:GLU228 4.8 57.6 1.0 CG B:GLU194 4.8 68.3 1.0 NE2 B:HIS231 4.8 56.9 1.0 CG B:GLN127 4.8 54.2 1.0 CD2 B:HIS134 4.9 51.9 1.0 CD2 B:HIS231 4.9 57.7 1.0 NE2 B:HIS134 4.9 52.6 1.0 CD B:GLN127 5.0 54.4 1.0

M.Welin, M.Moche, C.H.Arrowsmith, H.Berglund, R.D.Busam, R.Collins, L.G.Dahlgren, A.M.Edwards, S.Flodin, A.Flores, S.Graslund, M.Hammarstrom, M.D.Herman, A.Johansson, I.Johansson, A.Kallas, T.Karlberg, T.Kotenyova, L.Lehtio, M.E.Nilsson, T.Nyman, C.Persson, J.Sagemark, H.Schueler, L.Svensson, A.G.Thorsell, L.Tresaugues, S.Van Den Berg, J.Weigelt, M.Wikstrom, P.Nordlund. Human Ribonucleotide Reductase, Subunit M2 B To Be Published.