Iron in PDB 2yc0: Factor Inhibiting Hif-1 Alpha in Complex with R-2-Hydroxyglutarate

All present enzymatic activity of Factor Inhibiting Hif-1 Alpha in Complex with R-2-Hydroxyglutarate:
1.14.11.16;

The structure of Factor Inhibiting Hif-1 Alpha in Complex with R-2-Hydroxyglutarate, PDB code: 2yc0 was solved by R.Chowdhury, I.J.Clifton, C.J.Schofield, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	42.84 / 2.15
Space group	P 41 21 2
Cell size a, b, c (Å), α, β, γ (°)	86.794, 86.794, 147.759, 90.00, 90.00, 90.00
R / Rfree (%)	24.1 / 25.3

The binding sites of Iron atom in the Factor Inhibiting Hif-1 Alpha in Complex with R-2-Hydroxyglutarate (pdb code 2yc0). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total only one binding site of Iron was determined in the Factor Inhibiting Hif-1 Alpha in Complex with R-2-Hydroxyglutarate, PDB code: 2yc0:

Iron binding site 1 out of 1 in the Factor Inhibiting Hif-1 Alpha in Complex with R-2-Hydroxyglutarate


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Factor Inhibiting Hif-1 Alpha in Complex with R-2-Hydroxyglutarate within 5.0Å range: probe atom residue distance (Å) B Occ A:Fe501 b:41.1 occ:1.00 O3 A:2HG601 2.0 39.8 1.0 OD2 A:ASP201 2.1 34.6 1.0 O1 A:2HG601 2.1 44.1 1.0 NE2 A:HIS279 2.3 42.8 1.0 NE2 A:HIS199 2.3 37.0 1.0 O3 A:GOL604 2.6 59.1 1.0 C3 A:GOL604 2.8 61.9 1.0 C2 A:2HG601 2.8 44.7 1.0 C1 A:2HG601 2.8 43.2 1.0 CG A:ASP201 3.2 42.0 1.0 CE1 A:HIS279 3.3 41.5 1.0 CD2 A:HIS199 3.3 38.0 1.0 CE1 A:HIS199 3.3 39.0 1.0 CD2 A:HIS279 3.3 42.6 1.0 C2 A:GOL604 3.4 65.6 1.0 OD1 A:ASP201 3.5 40.4 1.0 O A:HOH2049 4.0 40.5 1.0 O2 A:2HG601 4.1 48.1 1.0 C3 A:2HG601 4.2 42.3 1.0 CZ2 A:TRP296 4.2 56.3 0.6 CZ2 A:TRP296 4.3 53.2 0.4 C1 A:GOL604 4.4 65.5 1.0 ND1 A:HIS279 4.4 43.8 1.0 ND1 A:HIS199 4.4 39.1 1.0 CG A:HIS199 4.4 37.0 1.0 CG A:HIS279 4.4 45.0 1.0 CB A:ASP201 4.5 40.1 1.0 O2 A:GOL604 4.5 68.1 1.0 C4 A:2HG601 4.8 45.4 1.0

R.Chowdhury, K.K.Yeoh, Y.M.Tian, L.Hillringhaus, E.A.Bagg, N.R.Rose, I.K.Leung, X.S.Li, E.C.Woon, M.Yang, M.A.Mcdonough, O.N.King, I.J.Clifton, R.J.Klose, T.D.Claridge, P.J.Ratcliffe, C.J.Schofield, A.Kawamura. The Oncometabolite 2-Hydroxyglutarate Inhibits Histone Lysine Demethylases. Embo Rep. V. 12 463 2011.
ISSN: ESSN 1469-3178
PubMed: 21460794
DOI: 10.1038/EMBOR.2011.43