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Iron in PDB 3erh: First Structural Evidence of Substrate Specificity in Mammalian Peroxidases: Crystal Structures of Substrate Complexes with Lactoperoxidases From Two Different Species

Enzymatic activity of First Structural Evidence of Substrate Specificity in Mammalian Peroxidases: Crystal Structures of Substrate Complexes with Lactoperoxidases From Two Different Species

All present enzymatic activity of First Structural Evidence of Substrate Specificity in Mammalian Peroxidases: Crystal Structures of Substrate Complexes with Lactoperoxidases From Two Different Species:
1.11.1.7;

Protein crystallography data

The structure of First Structural Evidence of Substrate Specificity in Mammalian Peroxidases: Crystal Structures of Substrate Complexes with Lactoperoxidases From Two Different Species, PDB code: 3erh was solved by I.A.Sheikh, N.Singh, A.K.Singh, M.Sinha, S.B.Singh, A.Bhushan, P.Kaur, A.Srinivasan, S.Sharma, T.P.Singh, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 19.46 / 2.40
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 54.207, 80.541, 77.877, 90.00, 102.64, 90.00
R / Rfree (%) 18 / 19.5

Other elements in 3erh:

The structure of First Structural Evidence of Substrate Specificity in Mammalian Peroxidases: Crystal Structures of Substrate Complexes with Lactoperoxidases From Two Different Species also contains other interesting chemical elements:

Iodine (I) 7 atoms
Calcium (Ca) 1 atom

Iron Binding Sites:

The binding sites of Iron atom in the First Structural Evidence of Substrate Specificity in Mammalian Peroxidases: Crystal Structures of Substrate Complexes with Lactoperoxidases From Two Different Species (pdb code 3erh). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total only one binding site of Iron was determined in the First Structural Evidence of Substrate Specificity in Mammalian Peroxidases: Crystal Structures of Substrate Complexes with Lactoperoxidases From Two Different Species, PDB code: 3erh:

Iron binding site 1 out of 1 in 3erh

Go back to Iron Binding Sites List in 3erh
Iron binding site 1 out of 1 in the First Structural Evidence of Substrate Specificity in Mammalian Peroxidases: Crystal Structures of Substrate Complexes with Lactoperoxidases From Two Different Species


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of First Structural Evidence of Substrate Specificity in Mammalian Peroxidases: Crystal Structures of Substrate Complexes with Lactoperoxidases From Two Different Species within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Fe605

b:26.2
occ:1.00
FE A:HEM605 0.0 26.2 1.0
NA A:HEM605 1.9 22.2 1.0
NB A:HEM605 2.0 22.1 1.0
ND A:HEM605 2.0 17.4 1.0
NC A:HEM605 2.1 20.3 1.0
NE2 A:HIS351 2.2 22.9 1.0
O A:HOH628 2.6 32.3 1.0
C1B A:HEM605 3.0 20.2 1.0
C4A A:HEM605 3.0 26.0 1.0
C1D A:HEM605 3.0 14.9 1.0
C1A A:HEM605 3.0 24.3 1.0
C4B A:HEM605 3.0 16.9 1.0
C4D A:HEM605 3.0 20.3 1.0
CD2 A:HIS351 3.1 20.9 1.0
C4C A:HEM605 3.1 19.3 1.0
C1C A:HEM605 3.1 20.0 1.0
CE1 A:HIS351 3.3 24.6 1.0
CHB A:HEM605 3.3 20.3 1.0
CHD A:HEM605 3.4 15.5 1.0
CHA A:HEM605 3.4 20.6 1.0
CHC A:HEM605 3.5 16.5 1.0
C2B A:HEM605 4.2 18.6 1.0
C3B A:HEM605 4.2 16.1 1.0
C3A A:HEM605 4.2 24.4 1.0
C2A A:HEM605 4.2 20.1 1.0
CG A:HIS351 4.3 23.4 1.0
C2D A:HEM605 4.3 13.2 1.0
C3D A:HEM605 4.3 16.9 1.0
C3C A:HEM605 4.3 16.4 1.0
ND1 A:HIS351 4.3 22.5 1.0
C2C A:HEM605 4.4 19.5 1.0
NE2 A:GLN105 4.5 20.7 1.0
NE2 A:HIS109 4.9 23.1 1.0

Reference:

I.A.Sheikh, A.K.Singh, N.Singh, M.Sinha, S.B.Singh, A.Bhushan, P.Kaur, A.Srinivasan, S.Sharma, T.P.Singh. Structural Evidence of Substrate Specificity in Mammalian Peroxidases: Structure of the Thiocyanate Complex with Lactoperoxidase and Its Interactions at 2.4 A Resolution J.Biol.Chem. V. 284 14849 2009.
ISSN: ISSN 0021-9258
PubMed: 19339248
DOI: 10.1074/JBC.M807644200
Page generated: Sun Dec 13 15:05:15 2020

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