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Iron in PDB 3fmq: Crystal Structure of An Encephalitozoon Cuniculi Methionine Aminopeptidase Type 2 with Angiogenesis Inhibitor Fumagillin Bound

Enzymatic activity of Crystal Structure of An Encephalitozoon Cuniculi Methionine Aminopeptidase Type 2 with Angiogenesis Inhibitor Fumagillin Bound

All present enzymatic activity of Crystal Structure of An Encephalitozoon Cuniculi Methionine Aminopeptidase Type 2 with Angiogenesis Inhibitor Fumagillin Bound:
3.4.11.18;

Protein crystallography data

The structure of Crystal Structure of An Encephalitozoon Cuniculi Methionine Aminopeptidase Type 2 with Angiogenesis Inhibitor Fumagillin Bound, PDB code: 3fmq was solved by J.J.Alvarado, M.Russell, A.Zhang, J.Adams, R.Toro, S.K.Burley, L.M.Weiss, S.C.Almo, New York Sgx Research Center For Structural Genomics(Nysgxrc), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 50.00 / 2.50
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 62.008, 94.238, 66.325, 90.00, 99.43, 90.00
R / Rfree (%) 17.3 / 22.9

Iron Binding Sites:

The binding sites of Iron atom in the Crystal Structure of An Encephalitozoon Cuniculi Methionine Aminopeptidase Type 2 with Angiogenesis Inhibitor Fumagillin Bound (pdb code 3fmq). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total 4 binding sites of Iron where determined in the Crystal Structure of An Encephalitozoon Cuniculi Methionine Aminopeptidase Type 2 with Angiogenesis Inhibitor Fumagillin Bound, PDB code: 3fmq:
Jump to Iron binding site number: 1; 2; 3; 4;

Iron binding site 1 out of 4 in 3fmq

Go back to Iron Binding Sites List in 3fmq
Iron binding site 1 out of 4 in the Crystal Structure of An Encephalitozoon Cuniculi Methionine Aminopeptidase Type 2 with Angiogenesis Inhibitor Fumagillin Bound


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Crystal Structure of An Encephalitozoon Cuniculi Methionine Aminopeptidase Type 2 with Angiogenesis Inhibitor Fumagillin Bound within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Fe451

b:20.6
occ:1.00
 OE2 A:GLU339 2.1 18.4 1.0
OD2 A:ASP141 2.2 15.5 1.0
NE2 A:HIS210 2.2 22.2 1.0
OE1 A:GLU243 2.6 24.9 1.0
FE A:FE452 2.9 20.2 1.0
CD A:GLU339 3.1 18.5 1.0
CD A:GLU243 3.1 25.6 1.0
CD2 A:HIS210 3.2 22.5 1.0
CG A:ASP141 3.2 14.6 1.0
O11 A:FUG481 3.2 28.3 1.0
CE1 A:HIS210 3.2 21.8 1.0
OE2 A:GLU243 3.3 27.0 1.0
OE1 A:GLU339 3.4 19.7 1.0
OD1 A:ASP141 3.6 14.0 1.0
CB A:ALA241 4.0 16.9 1.0
ND1 A:HIS210 4.3 22.4 1.0
CG A:HIS210 4.3 22.3 1.0
CG A:GLU243 4.4 22.2 1.0
CB A:ASP141 4.4 14.3 1.0
CG A:GLU339 4.4 16.2 1.0
C1 A:FUG481 4.6 28.4 1.0
OD2 A:ASP130 4.7 13.0 1.0
C2A A:FUG481 4.7 27.2 1.0
CB A:GLU243 4.8 19.3 1.0
C6 A:FUG481 4.9 27.9 1.0

Iron binding site 2 out of 4 in 3fmq

Go back to Iron Binding Sites List in 3fmq
Iron binding site 2 out of 4 in the Crystal Structure of An Encephalitozoon Cuniculi Methionine Aminopeptidase Type 2 with Angiogenesis Inhibitor Fumagillin Bound


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 2 of Crystal Structure of An Encephalitozoon Cuniculi Methionine Aminopeptidase Type 2 with Angiogenesis Inhibitor Fumagillin Bound within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Fe452

b:20.2
occ:1.00
 OE1 A:GLU339 2.0 19.7 1.0
OD1 A:ASP141 2.1 14.0 1.0
OD1 A:ASP130 2.2 15.2 1.0
OD2 A:ASP130 2.4 13.0 1.0
CG A:ASP130 2.6 12.8 1.0
CG A:ASP141 2.8 14.6 1.0
OD2 A:ASP141 2.9 15.5 1.0
CD A:GLU339 2.9 18.5 1.0
FE A:FE451 2.9 20.6 1.0
OE2 A:GLU339 3.1 18.4 1.0
OE2 A:GLU243 3.7 27.0 1.0
CZ A:PHE97 3.7 7.3 1.0
O A:HOH569 4.1 13.7 1.0
CB A:ASP130 4.1 11.7 1.0
CE1 A:PHE97 4.2 8.6 1.0
CD A:GLU243 4.2 25.6 1.0
CB A:ASP141 4.3 14.3 1.0
CG A:GLU339 4.4 16.2 1.0
NE2 A:GLN337 4.4 11.6 1.0
OE1 A:GLU243 4.5 24.9 1.0
O11 A:FUG481 4.6 28.3 1.0
CB A:ALA143 4.6 11.7 1.0
CE2 A:PHE97 4.7 7.0 1.0
N A:SER142 4.7 12.9 1.0
C A:ASP141 4.7 13.7 1.0
O A:SER142 4.8 13.2 1.0
CB A:GLU339 4.8 15.0 1.0
CA A:ASP141 4.9 14.3 1.0
CA A:ASP130 4.9 11.7 1.0
C A:SER142 4.9 12.9 1.0

Iron binding site 3 out of 4 in 3fmq

Go back to Iron Binding Sites List in 3fmq
Iron binding site 3 out of 4 in the Crystal Structure of An Encephalitozoon Cuniculi Methionine Aminopeptidase Type 2 with Angiogenesis Inhibitor Fumagillin Bound


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 3 of Crystal Structure of An Encephalitozoon Cuniculi Methionine Aminopeptidase Type 2 with Angiogenesis Inhibitor Fumagillin Bound within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Fe451

b:19.4
occ:1.00
 OE2 B:GLU339 2.2 13.7 1.0
NE2 B:HIS210 2.3 14.8 1.0
OD2 B:ASP141 2.3 13.9 1.0
OE2 B:GLU243 2.5 19.5 1.0
FE B:FE452 2.9 17.9 1.0
CD B:GLU339 3.1 13.0 1.0
CD B:GLU243 3.1 19.6 1.0
CG B:ASP141 3.2 11.8 1.0
CE1 B:HIS210 3.2 14.7 1.0
O11 B:FUG481 3.2 25.0 1.0
CD2 B:HIS210 3.3 14.6 1.0
OE1 B:GLU339 3.3 15.0 1.0
OE1 B:GLU243 3.3 21.5 1.0
OD1 B:ASP141 3.5 15.5 1.0
CB B:ALA241 4.0 10.7 1.0
CG B:GLU243 4.3 16.2 1.0
ND1 B:HIS210 4.3 14.4 1.0
CG B:HIS210 4.4 13.5 1.0
CB B:ASP141 4.5 9.9 1.0
CG B:GLU339 4.5 12.7 1.0
C1 B:FUG481 4.6 24.5 1.0
C2A B:FUG481 4.7 22.2 1.0
OD2 B:ASP130 4.8 10.8 1.0
CB B:GLU243 4.9 14.7 1.0

Iron binding site 4 out of 4 in 3fmq

Go back to Iron Binding Sites List in 3fmq
Iron binding site 4 out of 4 in the Crystal Structure of An Encephalitozoon Cuniculi Methionine Aminopeptidase Type 2 with Angiogenesis Inhibitor Fumagillin Bound


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 4 of Crystal Structure of An Encephalitozoon Cuniculi Methionine Aminopeptidase Type 2 with Angiogenesis Inhibitor Fumagillin Bound within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Fe452

b:17.9
occ:1.00
 OE1 B:GLU339 1.9 15.0 1.0
OD1 B:ASP141 2.1 15.5 1.0
OD1 B:ASP130 2.2 8.9 1.0
OD2 B:ASP130 2.5 10.8 1.0
CG B:ASP130 2.7 8.9 1.0
CD B:GLU339 2.9 13.0 1.0
FE B:FE451 2.9 19.4 1.0
CG B:ASP141 2.9 11.8 1.0
OD2 B:ASP141 3.0 13.9 1.0
OE2 B:GLU339 3.1 13.7 1.0
OE1 B:GLU243 3.8 21.5 1.0
CZ B:PHE97 3.9 5.1 1.0
CB B:ASP130 4.2 7.6 1.0
CG B:GLU339 4.2 12.7 1.0
CB B:ASP141 4.3 9.9 1.0
CE1 B:PHE97 4.4 5.2 1.0
NE2 B:GLN337 4.4 6.7 1.0
CD B:GLU243 4.5 19.6 1.0
O11 B:FUG481 4.5 25.0 1.0
OE2 B:GLU243 4.5 19.5 1.0
N B:SER142 4.6 8.8 1.0
C B:ASP141 4.7 9.1 1.0
CB B:ALA143 4.7 7.3 1.0
CB B:GLU339 4.8 10.7 1.0
CA B:ASP141 4.9 9.6 1.0
O B:SER142 4.9 8.4 1.0
CA B:ASP130 5.0 8.2 1.0
C B:SER142 5.0 8.3 1.0
CE2 B:PHE97 5.0 7.0 1.0

Reference:

J.J.Alvarado, A.Nemkal, J.M.Sauder, M.Russell, D.E.Akiyoshi, W.Shi, S.C.Almo, L.M.Weiss. Structure of A Microsporidian Methionine Aminopeptidase Type 2 Complexed with Fumagillin and Tnp-470. Mol.Biochem.Parasitol. V. 168 158 2009.
ISSN: ISSN 0166-6851
PubMed: 19660503
DOI: 10.1016/J.MOLBIOPARA.2009.07.008
Page generated: Sun Aug 4 10:07:31 2024

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