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Iron in PDB 3fmr: Crystal Structure of An Encephalitozoon Cuniculi Methionine Aminopeptidase Type 2 with Angiogenesis Inhibitor TNP470 Bound

Enzymatic activity of Crystal Structure of An Encephalitozoon Cuniculi Methionine Aminopeptidase Type 2 with Angiogenesis Inhibitor TNP470 Bound

All present enzymatic activity of Crystal Structure of An Encephalitozoon Cuniculi Methionine Aminopeptidase Type 2 with Angiogenesis Inhibitor TNP470 Bound:
3.4.11.18;

Protein crystallography data

The structure of Crystal Structure of An Encephalitozoon Cuniculi Methionine Aminopeptidase Type 2 with Angiogenesis Inhibitor TNP470 Bound, PDB code: 3fmr was solved by J.J.Alvarado, M.Russell, A.Zhang, J.Adams, R.Toro, S.K.Burley, L.M.Weiss, S.C.Almo, New York Sgx Research Center For Structural Genomics(Nysgxrc), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 50.00 / 2.89
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 61.977, 94.067, 66.407, 90.00, 99.33, 90.00
R / Rfree (%) 17.8 / 26.6

Iron Binding Sites:

The binding sites of Iron atom in the Crystal Structure of An Encephalitozoon Cuniculi Methionine Aminopeptidase Type 2 with Angiogenesis Inhibitor TNP470 Bound (pdb code 3fmr). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total 4 binding sites of Iron where determined in the Crystal Structure of An Encephalitozoon Cuniculi Methionine Aminopeptidase Type 2 with Angiogenesis Inhibitor TNP470 Bound, PDB code: 3fmr:
Jump to Iron binding site number: 1; 2; 3; 4;

Iron binding site 1 out of 4 in 3fmr

Go back to Iron Binding Sites List in 3fmr
Iron binding site 1 out of 4 in the Crystal Structure of An Encephalitozoon Cuniculi Methionine Aminopeptidase Type 2 with Angiogenesis Inhibitor TNP470 Bound


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Crystal Structure of An Encephalitozoon Cuniculi Methionine Aminopeptidase Type 2 with Angiogenesis Inhibitor TNP470 Bound within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Fe401

b:41.6
occ:1.00
 OE2 A:GLU339 2.2 25.7 1.0
NE2 A:HIS210 2.2 30.3 1.0
OD2 A:ASP141 2.3 24.9 1.0
OE1 A:GLU243 2.5 32.9 1.0
FE A:FE402 2.9 37.9 1.0
CE1 A:HIS210 3.0 29.6 1.0
CD A:GLU339 3.0 25.8 1.0
CD A:GLU243 3.1 33.0 1.0
CG A:ASP141 3.2 24.8 1.0
OE1 A:GLU339 3.2 26.7 1.0
OE2 A:GLU243 3.3 34.0 1.0
O11 A:TN4451 3.3 32.1 1.0
CD2 A:HIS210 3.4 29.9 1.0
OD1 A:ASP141 3.5 24.6 1.0
CB A:ALA241 4.2 26.1 1.0
ND1 A:HIS210 4.2 29.4 1.0
CG A:GLU243 4.3 30.1 1.0
CG A:HIS210 4.4 29.6 1.0
CB A:ASP141 4.4 24.1 1.0
CG A:GLU339 4.5 25.2 1.0
C1 A:TN4451 4.5 32.9 1.0
C2A A:TN4451 4.5 33.4 1.0
OD2 A:ASP130 4.5 22.6 1.0
C6 A:TN4451 4.6 32.2 1.0
CB A:GLU243 4.7 27.9 1.0

Iron binding site 2 out of 4 in 3fmr

Go back to Iron Binding Sites List in 3fmr
Iron binding site 2 out of 4 in the Crystal Structure of An Encephalitozoon Cuniculi Methionine Aminopeptidase Type 2 with Angiogenesis Inhibitor TNP470 Bound


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 2 of Crystal Structure of An Encephalitozoon Cuniculi Methionine Aminopeptidase Type 2 with Angiogenesis Inhibitor TNP470 Bound within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Fe402

b:37.9
occ:1.00
 OD1 A:ASP141 2.1 24.6 1.0
OE1 A:GLU339 2.1 26.7 1.0
OD1 A:ASP130 2.2 25.4 1.0
OD2 A:ASP130 2.3 22.6 1.0
CG A:ASP130 2.5 22.3 1.0
CG A:ASP141 2.9 24.8 1.0
FE A:FE401 2.9 41.6 1.0
OD2 A:ASP141 3.0 24.9 1.0
CD A:GLU339 3.1 25.8 1.0
OE2 A:GLU339 3.5 25.7 1.0
CZ A:PHE97 3.7 13.1 1.0
OE2 A:GLU243 3.9 34.0 1.0
CB A:ASP130 4.0 21.2 1.0
CE1 A:PHE97 4.2 14.4 1.0
CB A:ASP141 4.3 24.1 1.0
CD A:GLU243 4.3 33.0 1.0
NE2 A:GLN337 4.4 21.6 1.0
CG A:GLU339 4.4 25.2 1.0
CB A:ALA143 4.5 20.8 1.0
OE1 A:GLU243 4.6 32.9 1.0
C A:ASP141 4.6 23.7 1.0
N A:SER142 4.6 23.2 1.0
CE2 A:PHE97 4.7 13.3 1.0
CA A:ASP141 4.8 23.9 1.0
O11 A:TN4451 4.8 32.1 1.0
CA A:ASP130 4.8 21.1 1.0
CB A:GLU339 4.8 25.0 1.0
C A:SER142 4.9 22.5 1.0
O A:ASP141 4.9 23.9 1.0
C A:ASP130 5.0 21.0 1.0

Iron binding site 3 out of 4 in 3fmr

Go back to Iron Binding Sites List in 3fmr
Iron binding site 3 out of 4 in the Crystal Structure of An Encephalitozoon Cuniculi Methionine Aminopeptidase Type 2 with Angiogenesis Inhibitor TNP470 Bound


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 3 of Crystal Structure of An Encephalitozoon Cuniculi Methionine Aminopeptidase Type 2 with Angiogenesis Inhibitor TNP470 Bound within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Fe401

b:31.2
occ:1.00
 OD2 B:ASP141 2.1 20.6 1.0
OE2 B:GLU339 2.2 18.4 1.0
NE2 B:HIS210 2.3 17.4 1.0
OE2 B:GLU243 2.4 26.3 1.0
CD B:GLU243 3.0 24.9 1.0
FE B:FE402 3.1 27.8 1.0
CD B:GLU339 3.1 18.0 1.0
CG B:ASP141 3.1 19.1 1.0
CD2 B:HIS210 3.2 18.3 1.0
CE1 B:HIS210 3.2 18.3 1.0
OE1 B:GLU339 3.3 18.9 1.0
OE1 B:GLU243 3.3 25.4 1.0
O11 B:TN4451 3.5 22.5 1.0
OD1 B:ASP141 3.6 20.1 1.0
CB B:ALA241 4.0 18.6 1.0
CG B:GLU243 4.2 22.4 1.0
ND1 B:HIS210 4.4 18.3 1.0
CB B:ASP141 4.4 18.7 1.0
CG B:HIS210 4.4 19.6 1.0
CG B:GLU339 4.5 18.0 1.0
C2A B:TN4451 4.7 21.6 1.0
C1 B:TN4451 4.8 22.2 1.0
CD1 B:ILE217 4.8 31.1 1.0
OD2 B:ASP130 4.9 20.2 1.0
CB B:GLU243 4.9 21.2 1.0

Iron binding site 4 out of 4 in 3fmr

Go back to Iron Binding Sites List in 3fmr
Iron binding site 4 out of 4 in the Crystal Structure of An Encephalitozoon Cuniculi Methionine Aminopeptidase Type 2 with Angiogenesis Inhibitor TNP470 Bound


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 4 of Crystal Structure of An Encephalitozoon Cuniculi Methionine Aminopeptidase Type 2 with Angiogenesis Inhibitor TNP470 Bound within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Fe402

b:27.8
occ:1.00
 OE1 B:GLU339 2.0 18.9 1.0
OD1 B:ASP130 2.1 18.9 1.0
OD1 B:ASP141 2.2 20.1 1.0
OD2 B:ASP130 2.5 20.2 1.0
CG B:ASP130 2.6 17.9 1.0
CD B:GLU339 3.0 18.0 1.0
CG B:ASP141 3.0 19.1 1.0
FE B:FE401 3.1 31.2 1.0
OD2 B:ASP141 3.1 20.6 1.0
OE2 B:GLU339 3.3 18.4 1.0
OE1 B:GLU243 3.8 25.4 1.0
CZ B:PHE97 4.0 17.2 1.0
CB B:ASP130 4.1 17.1 1.0
NE2 B:GLN337 4.2 21.8 1.0
CG B:GLU339 4.4 18.0 1.0
CB B:ASP141 4.4 18.7 1.0
CB B:ALA143 4.4 19.1 1.0
CE1 B:PHE97 4.5 16.9 1.0
CD B:GLU243 4.5 24.9 1.0
O B:SER142 4.6 19.5 1.0
OE2 B:GLU243 4.6 26.3 1.0
C B:ASP141 4.6 18.7 1.0
N B:SER142 4.7 19.0 1.0
CB B:GLU339 4.8 18.0 1.0
C B:SER142 4.8 19.4 1.0
CA B:ASP130 4.8 16.8 1.0
O11 B:TN4451 4.8 22.5 1.0
CA B:ASP141 4.9 18.6 1.0
O B:ASP141 4.9 18.6 1.0
C B:ASP130 5.0 16.9 1.0

Reference:

J.J.Alvarado, A.Nemkal, J.M.Sauder, M.Russell, D.E.Akiyoshi, W.Shi, S.C.Almo, L.M.Weiss. Structure of A Microsporidian Methionine Aminopeptidase Type 2 Complexed with Fumagillin and Tnp-470. Mol.Biochem.Parasitol. V. 168 158 2009.
ISSN: ISSN 0166-6851
PubMed: 19660503
DOI: 10.1016/J.MOLBIOPARA.2009.07.008
Page generated: Sun Aug 4 10:07:37 2024

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