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Iron in PDB 3g93: Single Ligand Occupancy Crystal Structure of Cytochrome P450 2B4 in Complex with the Inhibitor 1-Biphenyl-4-Methyl-1H-Imidazole
Enzymatic activity of Single Ligand Occupancy Crystal Structure of Cytochrome P450 2B4 in Complex with the Inhibitor 1-Biphenyl-4-Methyl-1H-Imidazole
All present enzymatic activity of Single Ligand Occupancy Crystal Structure of Cytochrome P450 2B4 in Complex with the Inhibitor 1-Biphenyl-4-Methyl-1H-Imidazole:
1.14.14.1;
1.14.14.1;
Protein crystallography data
The structure of Single Ligand Occupancy Crystal Structure of Cytochrome P450 2B4 in Complex with the Inhibitor 1-Biphenyl-4-Methyl-1H-Imidazole, PDB code: 3g93
was solved by
S.C.Gay,
L.Sun,
K.Maekawa,
J.R.Halpert,
C.D.Stout,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 48.75 / 3.20 |
| Space group | P 21 21 21 |
| Cell size a, b, c (Å), α, β, γ (°) | 86.910, 151.815, 181.583, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 23.7 / 27 |
Iron Binding Sites:
The binding sites of Iron atom in the Single Ligand Occupancy Crystal Structure of Cytochrome P450 2B4 in Complex with the Inhibitor 1-Biphenyl-4-Methyl-1H-Imidazole
(pdb code 3g93). This binding sites where shown within
5.0 Angstroms radius around Iron atom.
In total 4 binding sites of Iron where determined in the Single Ligand Occupancy Crystal Structure of Cytochrome P450 2B4 in Complex with the Inhibitor 1-Biphenyl-4-Methyl-1H-Imidazole, PDB code: 3g93:
Jump to Iron binding site number: 1; 2; 3; 4;
In total 4 binding sites of Iron where determined in the Single Ligand Occupancy Crystal Structure of Cytochrome P450 2B4 in Complex with the Inhibitor 1-Biphenyl-4-Methyl-1H-Imidazole, PDB code: 3g93:
Jump to Iron binding site number: 1; 2; 3; 4;
Iron binding site 1 out of 4 in 3g93
Go back to
Iron Binding Sites List in 3g93
Iron binding site 1 out
of 4 in the Single Ligand Occupancy Crystal Structure of Cytochrome P450 2B4 in Complex with the Inhibitor 1-Biphenyl-4-Methyl-1H-Imidazole
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Iron with other atoms in the Fe binding
site number 1 of Single Ligand Occupancy Crystal Structure of Cytochrome P450 2B4 in Complex with the Inhibitor 1-Biphenyl-4-Methyl-1H-Imidazole within 5.0Å range:
|
Iron binding site 2 out of 4 in 3g93
Go back to
Iron Binding Sites List in 3g93
Iron binding site 2 out
of 4 in the Single Ligand Occupancy Crystal Structure of Cytochrome P450 2B4 in Complex with the Inhibitor 1-Biphenyl-4-Methyl-1H-Imidazole
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Iron with other atoms in the Fe binding
site number 2 of Single Ligand Occupancy Crystal Structure of Cytochrome P450 2B4 in Complex with the Inhibitor 1-Biphenyl-4-Methyl-1H-Imidazole within 5.0Å range:
|
Iron binding site 3 out of 4 in 3g93
Go back to
Iron Binding Sites List in 3g93
Iron binding site 3 out
of 4 in the Single Ligand Occupancy Crystal Structure of Cytochrome P450 2B4 in Complex with the Inhibitor 1-Biphenyl-4-Methyl-1H-Imidazole
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Iron with other atoms in the Fe binding
site number 3 of Single Ligand Occupancy Crystal Structure of Cytochrome P450 2B4 in Complex with the Inhibitor 1-Biphenyl-4-Methyl-1H-Imidazole within 5.0Å range:
|
Iron binding site 4 out of 4 in 3g93
Go back to
Iron Binding Sites List in 3g93
Iron binding site 4 out
of 4 in the Single Ligand Occupancy Crystal Structure of Cytochrome P450 2B4 in Complex with the Inhibitor 1-Biphenyl-4-Methyl-1H-Imidazole
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Iron with other atoms in the Fe binding
site number 4 of Single Ligand Occupancy Crystal Structure of Cytochrome P450 2B4 in Complex with the Inhibitor 1-Biphenyl-4-Methyl-1H-Imidazole within 5.0Å range:
|
Reference:
S.C.Gay,
L.Sun,
K.Maekawa,
J.R.Halpert,
C.D.Stout.
Crystal Structures of Cytochrome P450 2B4 in Complex with the Inhibitor 1-Biphenyl-4-Methyl-1H-Imidazole: Ligand-Induced Structural Response Through Alpha-Helical Repositioning. Biochemistry V. 48 4762 2009.
ISSN: ISSN 0006-2960
PubMed: 19397311
DOI: 10.1021/BI9003765
Page generated: Sun Aug 4 10:26:15 2024
ISSN: ISSN 0006-2960
PubMed: 19397311
DOI: 10.1021/BI9003765
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