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Atomistry » Iron » PDB 3k9z-3kyw » 3ksw » |
Iron in PDB 3ksw: Crystal Structure of Sterol 14ALPHA-Demethylase (CYP51) From Trypanosoma Cruzi in Complex with An Inhibitor Vnf ((4-(4- Chlorophenyl)-N-[2-(1H-Imidazol-1-Yl)-1-Phenylethyl]Benzamide)Enzymatic activity of Crystal Structure of Sterol 14ALPHA-Demethylase (CYP51) From Trypanosoma Cruzi in Complex with An Inhibitor Vnf ((4-(4- Chlorophenyl)-N-[2-(1H-Imidazol-1-Yl)-1-Phenylethyl]Benzamide)
All present enzymatic activity of Crystal Structure of Sterol 14ALPHA-Demethylase (CYP51) From Trypanosoma Cruzi in Complex with An Inhibitor Vnf ((4-(4- Chlorophenyl)-N-[2-(1H-Imidazol-1-Yl)-1-Phenylethyl]Benzamide):
1.14.13.70; Protein crystallography data
The structure of Crystal Structure of Sterol 14ALPHA-Demethylase (CYP51) From Trypanosoma Cruzi in Complex with An Inhibitor Vnf ((4-(4- Chlorophenyl)-N-[2-(1H-Imidazol-1-Yl)-1-Phenylethyl]Benzamide), PDB code: 3ksw
was solved by
G.I.Lepesheva,
T.Y.Hargrove,
S.Anderson,
Z.Wawrzak,
M.R.Waterman,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 3ksw:
The structure of Crystal Structure of Sterol 14ALPHA-Demethylase (CYP51) From Trypanosoma Cruzi in Complex with An Inhibitor Vnf ((4-(4- Chlorophenyl)-N-[2-(1H-Imidazol-1-Yl)-1-Phenylethyl]Benzamide) also contains other interesting chemical elements:
Iron Binding Sites:
The binding sites of Iron atom in the Crystal Structure of Sterol 14ALPHA-Demethylase (CYP51) From Trypanosoma Cruzi in Complex with An Inhibitor Vnf ((4-(4- Chlorophenyl)-N-[2-(1H-Imidazol-1-Yl)-1-Phenylethyl]Benzamide)
(pdb code 3ksw). This binding sites where shown within
5.0 Angstroms radius around Iron atom.
In total only one binding site of Iron was determined in the Crystal Structure of Sterol 14ALPHA-Demethylase (CYP51) From Trypanosoma Cruzi in Complex with An Inhibitor Vnf ((4-(4- Chlorophenyl)-N-[2-(1H-Imidazol-1-Yl)-1-Phenylethyl]Benzamide), PDB code: 3ksw: Iron binding site 1 out of 1 in 3kswGo back to![]() ![]()
Iron binding site 1 out
of 1 in the Crystal Structure of Sterol 14ALPHA-Demethylase (CYP51) From Trypanosoma Cruzi in Complex with An Inhibitor Vnf ((4-(4- Chlorophenyl)-N-[2-(1H-Imidazol-1-Yl)-1-Phenylethyl]Benzamide)
![]() Mono view ![]() Stereo pair view
Reference:
G.I.Lepesheva,
T.Y.Hargrove,
S.Anderson,
Y.Kleshchenko,
V.Furtak,
Z.Wawrzak,
F.Villalta,
M.R.Waterman.
Structural Insights Into Inhibition of Sterol 14{Alpha}-Demethylase in the Human Pathogen Trypanosoma Cruzi. J.Biol.Chem. V. 285 25582 2010.
Page generated: Sun Aug 4 13:58:57 2024
ISSN: ISSN 0021-9258 PubMed: 20530488 DOI: 10.1074/JBC.M110.133215 |
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