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Iron in PDB 3me6: Crystal Structure of Cytochrome 2B4 in Complex with the Anti-Platelet Drug Clopidogrel
Enzymatic activity of Crystal Structure of Cytochrome 2B4 in Complex with the Anti-Platelet Drug Clopidogrel
All present enzymatic activity of Crystal Structure of Cytochrome 2B4 in Complex with the Anti-Platelet Drug Clopidogrel:
1.14.14.1;
1.14.14.1;
Protein crystallography data
The structure of Crystal Structure of Cytochrome 2B4 in Complex with the Anti-Platelet Drug Clopidogrel, PDB code: 3me6
was solved by
S.C.Gay,
A.G.Roberts,
K.Maekawa,
J.C.Talakad,
W.X.Hong,
Q.Zhang,
C.D.Stout,
J.R.Halpert,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 76.75 / 3.10 |
| Space group | P 3 |
| Cell size a, b, c (Å), α, β, γ (°) | 234.490, 234.490, 57.320, 90.00, 90.00, 120.00 |
| R / Rfree (%) | 17.8 / 23.4 |
Other elements in 3me6:
The structure of Crystal Structure of Cytochrome 2B4 in Complex with the Anti-Platelet Drug Clopidogrel also contains other interesting chemical elements:
| Chlorine | (Cl) | 4 atoms |
Iron Binding Sites:
The binding sites of Iron atom in the Crystal Structure of Cytochrome 2B4 in Complex with the Anti-Platelet Drug Clopidogrel
(pdb code 3me6). This binding sites where shown within
5.0 Angstroms radius around Iron atom.
In total 4 binding sites of Iron where determined in the Crystal Structure of Cytochrome 2B4 in Complex with the Anti-Platelet Drug Clopidogrel, PDB code: 3me6:
Jump to Iron binding site number: 1; 2; 3; 4;
In total 4 binding sites of Iron where determined in the Crystal Structure of Cytochrome 2B4 in Complex with the Anti-Platelet Drug Clopidogrel, PDB code: 3me6:
Jump to Iron binding site number: 1; 2; 3; 4;
Iron binding site 1 out of 4 in 3me6
Go back to
Iron Binding Sites List in 3me6
Iron binding site 1 out
of 4 in the Crystal Structure of Cytochrome 2B4 in Complex with the Anti-Platelet Drug Clopidogrel
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Iron with other atoms in the Fe binding
site number 1 of Crystal Structure of Cytochrome 2B4 in Complex with the Anti-Platelet Drug Clopidogrel within 5.0Å range:
|
Iron binding site 2 out of 4 in 3me6
Go back to
Iron Binding Sites List in 3me6
Iron binding site 2 out
of 4 in the Crystal Structure of Cytochrome 2B4 in Complex with the Anti-Platelet Drug Clopidogrel
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Iron with other atoms in the Fe binding
site number 2 of Crystal Structure of Cytochrome 2B4 in Complex with the Anti-Platelet Drug Clopidogrel within 5.0Å range:
|
Iron binding site 3 out of 4 in 3me6
Go back to
Iron Binding Sites List in 3me6
Iron binding site 3 out
of 4 in the Crystal Structure of Cytochrome 2B4 in Complex with the Anti-Platelet Drug Clopidogrel
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Iron with other atoms in the Fe binding
site number 3 of Crystal Structure of Cytochrome 2B4 in Complex with the Anti-Platelet Drug Clopidogrel within 5.0Å range:
|
Iron binding site 4 out of 4 in 3me6
Go back to
Iron Binding Sites List in 3me6
Iron binding site 4 out
of 4 in the Crystal Structure of Cytochrome 2B4 in Complex with the Anti-Platelet Drug Clopidogrel
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Iron with other atoms in the Fe binding
site number 4 of Crystal Structure of Cytochrome 2B4 in Complex with the Anti-Platelet Drug Clopidogrel within 5.0Å range:
|
Reference:
S.C.Gay,
A.G.Roberts,
K.Maekawa,
J.C.Talakad,
W.X.Hong,
Q.Zhang,
C.D.Stout,
J.R.Halpert.
Structures of Cytochrome P450 2B4 Complexed with the Antiplatelet Drugs Ticlopidine and Clopidogrel. Biochemistry V. 49 8709 2010.
ISSN: ISSN 0006-2960
PubMed: 20815363
DOI: 10.1021/BI100914Z
Page generated: Sun Dec 13 15:12:15 2020
ISSN: ISSN 0006-2960
PubMed: 20815363
DOI: 10.1021/BI100914Z
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