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Iron in PDB 3qu8: Crystal Structure of A Human Cytochrome P450 2B6 (Y226H/K262R) in Complex with the Inhibitor 4-(4-Nitrobenzyl)Pyridine.
Enzymatic activity of Crystal Structure of A Human Cytochrome P450 2B6 (Y226H/K262R) in Complex with the Inhibitor 4-(4-Nitrobenzyl)Pyridine.
All present enzymatic activity of Crystal Structure of A Human Cytochrome P450 2B6 (Y226H/K262R) in Complex with the Inhibitor 4-(4-Nitrobenzyl)Pyridine.:
1.14.14.1;
1.14.14.1;
Protein crystallography data
The structure of Crystal Structure of A Human Cytochrome P450 2B6 (Y226H/K262R) in Complex with the Inhibitor 4-(4-Nitrobenzyl)Pyridine., PDB code: 3qu8
was solved by
M.B.Shah,
J.Pascual,
C.D.Stout,
J.R.Halpert,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 50.51 / 2.80 |
| Space group | P 32 |
| Cell size a, b, c (Å), α, β, γ (°) | 101.880, 101.880, 299.509, 90.00, 90.00, 120.00 |
| R / Rfree (%) | 21.8 / 25.9 |
Iron Binding Sites:
The binding sites of Iron atom in the Crystal Structure of A Human Cytochrome P450 2B6 (Y226H/K262R) in Complex with the Inhibitor 4-(4-Nitrobenzyl)Pyridine.
(pdb code 3qu8). This binding sites where shown within
5.0 Angstroms radius around Iron atom.
In total 6 binding sites of Iron where determined in the Crystal Structure of A Human Cytochrome P450 2B6 (Y226H/K262R) in Complex with the Inhibitor 4-(4-Nitrobenzyl)Pyridine., PDB code: 3qu8:
Jump to Iron binding site number: 1; 2; 3; 4; 5; 6;
In total 6 binding sites of Iron where determined in the Crystal Structure of A Human Cytochrome P450 2B6 (Y226H/K262R) in Complex with the Inhibitor 4-(4-Nitrobenzyl)Pyridine., PDB code: 3qu8:
Jump to Iron binding site number: 1; 2; 3; 4; 5; 6;
Iron binding site 1 out of 6 in 3qu8
Go back to
Iron Binding Sites List in 3qu8
Iron binding site 1 out
of 6 in the Crystal Structure of A Human Cytochrome P450 2B6 (Y226H/K262R) in Complex with the Inhibitor 4-(4-Nitrobenzyl)Pyridine.
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Iron with other atoms in the Fe binding
site number 1 of Crystal Structure of A Human Cytochrome P450 2B6 (Y226H/K262R) in Complex with the Inhibitor 4-(4-Nitrobenzyl)Pyridine. within 5.0Å range:
|
Iron binding site 2 out of 6 in 3qu8
Go back to
Iron Binding Sites List in 3qu8
Iron binding site 2 out
of 6 in the Crystal Structure of A Human Cytochrome P450 2B6 (Y226H/K262R) in Complex with the Inhibitor 4-(4-Nitrobenzyl)Pyridine.
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Iron with other atoms in the Fe binding
site number 2 of Crystal Structure of A Human Cytochrome P450 2B6 (Y226H/K262R) in Complex with the Inhibitor 4-(4-Nitrobenzyl)Pyridine. within 5.0Å range:
|
Iron binding site 3 out of 6 in 3qu8
Go back to
Iron Binding Sites List in 3qu8
Iron binding site 3 out
of 6 in the Crystal Structure of A Human Cytochrome P450 2B6 (Y226H/K262R) in Complex with the Inhibitor 4-(4-Nitrobenzyl)Pyridine.
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Iron with other atoms in the Fe binding
site number 3 of Crystal Structure of A Human Cytochrome P450 2B6 (Y226H/K262R) in Complex with the Inhibitor 4-(4-Nitrobenzyl)Pyridine. within 5.0Å range:
|
Iron binding site 4 out of 6 in 3qu8
Go back to
Iron Binding Sites List in 3qu8
Iron binding site 4 out
of 6 in the Crystal Structure of A Human Cytochrome P450 2B6 (Y226H/K262R) in Complex with the Inhibitor 4-(4-Nitrobenzyl)Pyridine.
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Iron with other atoms in the Fe binding
site number 4 of Crystal Structure of A Human Cytochrome P450 2B6 (Y226H/K262R) in Complex with the Inhibitor 4-(4-Nitrobenzyl)Pyridine. within 5.0Å range:
|
Iron binding site 5 out of 6 in 3qu8
Go back to
Iron Binding Sites List in 3qu8
Iron binding site 5 out
of 6 in the Crystal Structure of A Human Cytochrome P450 2B6 (Y226H/K262R) in Complex with the Inhibitor 4-(4-Nitrobenzyl)Pyridine.
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Iron with other atoms in the Fe binding
site number 5 of Crystal Structure of A Human Cytochrome P450 2B6 (Y226H/K262R) in Complex with the Inhibitor 4-(4-Nitrobenzyl)Pyridine. within 5.0Å range:
|
Iron binding site 6 out of 6 in 3qu8
Go back to
Iron Binding Sites List in 3qu8
Iron binding site 6 out
of 6 in the Crystal Structure of A Human Cytochrome P450 2B6 (Y226H/K262R) in Complex with the Inhibitor 4-(4-Nitrobenzyl)Pyridine.
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Iron with other atoms in the Fe binding
site number 6 of Crystal Structure of A Human Cytochrome P450 2B6 (Y226H/K262R) in Complex with the Inhibitor 4-(4-Nitrobenzyl)Pyridine. within 5.0Å range:
|
Reference:
M.B.Shah,
J.Pascual,
Q.Zhang,
C.D.Stout,
J.R.Halpert.
Structures of Cytochrome P450 2B6 Bound to 4-Benzylpyridine and 4-(4-Nitrobenzyl)Pyridine: Insight Into Inhibitor Binding and Rearrangement of Active Site Side Chains. Mol.Pharmacol. V. 80 1047 2011.
ISSN: ISSN 0026-895X
PubMed: 21875942
DOI: 10.1124/MOL.111.074427
Page generated: Sun Dec 13 15:19:26 2020
ISSN: ISSN 0026-895X
PubMed: 21875942
DOI: 10.1124/MOL.111.074427
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