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Iron in PDB 3zku: Isopenicillin N Synthase with Substrate Analogue Ahcv

Enzymatic activity of Isopenicillin N Synthase with Substrate Analogue Ahcv

All present enzymatic activity of Isopenicillin N Synthase with Substrate Analogue Ahcv:
1.21.3.1;

Protein crystallography data

The structure of Isopenicillin N Synthase with Substrate Analogue Ahcv, PDB code: 3zku was solved by A.Daruzzaman, I.J.Clifton, P.J.Rutledge, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 41.22 / 1.40
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 46.480, 71.105, 101.045, 90.00, 90.00, 90.00
R / Rfree (%) 16.1 / 18.3

Iron Binding Sites:

The binding sites of Iron atom in the Isopenicillin N Synthase with Substrate Analogue Ahcv (pdb code 3zku). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total only one binding site of Iron was determined in the Isopenicillin N Synthase with Substrate Analogue Ahcv, PDB code: 3zku:

Iron binding site 1 out of 1 in 3zku

Go back to Iron Binding Sites List in 3zku
Iron binding site 1 out of 1 in the Isopenicillin N Synthase with Substrate Analogue Ahcv


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Isopenicillin N Synthase with Substrate Analogue Ahcv within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Fe1328

b:10.0
occ:1.00
O A:HOH2199 2.1 13.9 1.0
OD1 A:ASP216 2.1 10.4 1.0
NE2 A:HIS214 2.2 10.0 1.0
NE2 A:HIS270 2.2 9.9 1.0
O A:HCV1329 2.3 25.5 0.5
C2 A:HCV1329 2.3 13.2 0.5
C2 A:HCV1329 2.4 14.5 0.5
O A:HCV1329 2.4 9.5 0.5
CG A:ASP216 3.1 9.4 1.0
CE1 A:HIS270 3.1 9.3 1.0
CE1 A:HIS214 3.1 10.5 1.0
CD2 A:HIS214 3.2 9.7 1.0
C1 A:HCV1329 3.2 22.1 0.5
CD2 A:HIS270 3.2 9.1 1.0
OD2 A:ASP216 3.4 9.3 1.0
C4 A:HCV1329 3.4 24.8 0.5
C1 A:HCV1329 3.5 20.8 0.5
C4 A:HCV1329 3.5 32.3 0.5
N A:HCV1329 3.9 25.4 0.5
C3 A:HCV1329 4.2 23.6 0.5
C A:HCV1329 4.2 20.1 0.5
ND1 A:HIS270 4.3 9.0 1.0
ND1 A:HIS214 4.3 10.3 1.0
O A:HOH2223 4.3 24.4 1.0
N A:HCV1329 4.3 27.8 0.5
CG A:HIS214 4.3 9.8 1.0
CG A:HIS270 4.3 9.4 1.0
C A:HCV1329 4.3 22.5 0.5
C6 A:HCV1329 4.4 33.4 0.5
C3 A:HCV1329 4.4 23.8 0.5
O1 A:HCV1329 4.4 28.7 0.5
CB A:ASP216 4.4 9.2 1.0
C5 A:HCV1329 4.5 28.7 0.5
C5 A:HCV1329 4.6 27.1 0.5
O A:HOH2200 4.7 20.2 1.0
CA A:ASP216 4.8 9.3 1.0
C6 A:HCV1329 4.8 34.3 0.5
N A:ASP216 4.9 9.4 1.0

Reference:

A.Daruzzaman, I.J.Clifton, R.M.Adlington, J.E.Baldwin, P.J.Rutledge. The Interaction of Isopenicillin N Synthase with Homologated Substrate Analogues Delta-(L-Alpha-Aminoadipoyl)-L-Homocysteinyl-D-Xaa Characterised By Protein Crystallography. Chembiochem V. 14 599 2013.
ISSN: ISSN 1439-4227
PubMed: 23468426
DOI: 10.1002/CBIC.201200728
Page generated: Sun Dec 13 15:27:18 2020

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