Iron in PDB 3zyv: Crystal Structure of the Mouse Liver Aldehyde Oxidase 3 (MAOX3)

All present enzymatic activity of Crystal Structure of the Mouse Liver Aldehyde Oxidase 3 (MAOX3):
1.2.3.1;

The structure of Crystal Structure of the Mouse Liver Aldehyde Oxidase 3 (MAOX3), PDB code: 3zyv was solved by J.Trincao, C.Coelho, M.Mahro, D.Rodrigues, M.Terao, E.Garattini, S.Leimkuehler, M.J.Romao, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	49.906 / 2.54
Space group	P 1
Cell size a, b, c (Å), α, β, γ (°)	90.880, 135.270, 147.370, 78.16, 77.72, 89.90
R / Rfree (%)	25.55 / 28.5

The structure of Crystal Structure of the Mouse Liver Aldehyde Oxidase 3 (MAOX3) also contains other interesting chemical elements:

Molybdenum	(Mo)	4 atoms
Sodium	(Na)	4 atoms

Pages:

>>> Page 1 <<< Page 2, Binding sites: 11 - 16;

Binding sites:

The binding sites of Iron atom in the Crystal Structure of the Mouse Liver Aldehyde Oxidase 3 (MAOX3) (pdb code 3zyv). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total 16 binding sites of Iron where determined in the Crystal Structure of the Mouse Liver Aldehyde Oxidase 3 (MAOX3), PDB code: 3zyv:
Jump to Iron binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9; 10;

Iron binding site 1 out of 16 in the Crystal Structure of the Mouse Liver Aldehyde Oxidase 3 (MAOX3)


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Crystal Structure of the Mouse Liver Aldehyde Oxidase 3 (MAOX3) within 5.0Å range: probe atom residue distance (Å) B Occ A:Fe3001 b:26.0 occ:1.00 FE1 A:FES3001 0.0 26.0 1.0 S2 A:FES3001 2.2 23.9 1.0 S1 A:FES3001 2.2 19.2 1.0 SG A:CYS152 2.2 33.5 1.0 SG A:CYS120 2.2 21.6 1.0 FE2 A:FES3001 3.1 20.1 1.0 CB A:CYS120 3.1 20.7 1.0 CB A:CYS152 3.5 33.6 1.0 CA A:CYS152 4.0 33.9 1.0 N A:CYS120 4.1 18.8 1.0 CA A:CYS120 4.2 15.6 1.0 N A:ARG153 4.4 25.5 1.0 SG A:CYS117 4.5 27.4 1.0 SG A:CYS154 4.5 30.0 1.0 CB A:CYS154 4.6 29.8 1.0 N A:CYS154 4.6 35.4 1.0 CG2 A:THR155 4.7 15.9 1.0 C A:CYS152 4.7 31.4 1.0 C A:CYS120 4.7 15.0 1.0

Iron binding site 2 out of 16 in the Crystal Structure of the Mouse Liver Aldehyde Oxidase 3 (MAOX3)


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 2 of Crystal Structure of the Mouse Liver Aldehyde Oxidase 3 (MAOX3) within 5.0Å range: probe atom residue distance (Å) B Occ A:Fe3001 b:20.1 occ:1.00 FE2 A:FES3001 0.0 20.1 1.0 SG A:CYS117 2.1 27.4 1.0 SG A:CYS154 2.2 30.0 1.0 S1 A:FES3001 2.2 19.2 1.0 S2 A:FES3001 2.2 23.9 1.0 CB A:CYS117 2.8 35.6 1.0 FE1 A:FES3001 3.1 26.0 1.0 CB A:CYS154 3.3 29.8 1.0 N A:CYS117 3.4 23.5 1.0 CA A:CYS117 3.5 29.6 1.0 N A:GLY118 4.0 21.1 1.0 O A:HOH2129 4.0 23.9 1.0 C A:CYS117 4.1 24.0 1.0 N A:CYS154 4.3 35.4 1.0 CA A:CYS154 4.4 28.3 1.0 SG A:CYS152 4.5 33.5 1.0 N A:PHE119 4.6 22.7 1.0 C A:GLN116 4.6 26.9 1.0 CB A:GLN116 4.9 14.9 1.0

Iron binding site 3 out of 16 in the Crystal Structure of the Mouse Liver Aldehyde Oxidase 3 (MAOX3)


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 3 of Crystal Structure of the Mouse Liver Aldehyde Oxidase 3 (MAOX3) within 5.0Å range: probe atom residue distance (Å) B Occ A:Fe3002 b:33.6 occ:1.00 FE1 A:FES3002 0.0 33.6 1.0 S2 A:FES3002 2.2 23.0 1.0 S1 A:FES3002 2.2 16.4 1.0 SG A:CYS52 2.4 60.1 1.0 SG A:CYS47 2.6 62.0 1.0 FE2 A:FES3002 3.0 38.9 1.0 N A:GLY48 3.4 47.2 1.0 N A:CYS47 3.7 43.1 1.0 CB A:CYS52 3.8 30.6 1.0 N A:CYS52 3.8 35.4 1.0 CB A:CYS47 3.8 47.5 1.0 CA A:CYS47 4.0 47.9 1.0 C A:CYS47 4.1 53.3 1.0 N A:GLY50 4.2 41.7 1.0 CA A:CYS52 4.2 32.6 1.0 N A:ASP51 4.2 38.1 1.0 CA A:GLY48 4.2 42.6 1.0 N A:GLY53 4.3 19.6 1.0 N A:GLY49 4.4 39.0 1.0 C A:CYS52 4.5 28.0 1.0 SG A:CYS77 4.5 35.2 1.0 N A:GLY46 4.5 31.0 1.0 CA A:GLY50 4.6 38.8 1.0 N A:ALA54 4.6 17.8 1.0 C A:GLY46 4.6 39.9 1.0 C A:GLY48 4.6 40.8 1.0 SG A:CYS55 4.7 30.4 1.0 C A:GLY50 4.8 36.9 1.0 C A:ASP51 4.9 37.6 1.0

Iron binding site 4 out of 16 in the Crystal Structure of the Mouse Liver Aldehyde Oxidase 3 (MAOX3)


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 4 of Crystal Structure of the Mouse Liver Aldehyde Oxidase 3 (MAOX3) within 5.0Å range: probe atom residue distance (Å) B Occ A:Fe3002 b:38.9 occ:1.00 FE2 A:FES3002 0.0 38.9 1.0 S2 A:FES3002 2.2 23.0 1.0 S1 A:FES3002 2.2 16.4 1.0 SG A:CYS55 2.2 30.4 1.0 SG A:CYS77 2.2 35.2 1.0 FE1 A:FES3002 3.0 33.6 1.0 CB A:CYS77 3.4 26.0 1.0 CB A:CYS55 3.7 17.6 1.0 CG2 A:THR75 3.9 20.8 1.0 CB A:THR75 3.9 20.9 1.0 CA A:GLY50 4.1 38.8 1.0 N A:GLY50 4.2 41.7 1.0 N A:CYS77 4.2 30.6 1.0 N A:CYS55 4.4 17.1 1.0 CA A:CYS77 4.4 28.2 1.0 CA A:CYS55 4.6 16.9 1.0 CA A:GLY48 4.6 42.6 1.0 CA A:THR75 4.7 23.6 1.0 N A:GLY48 4.7 47.2 1.0 C A:GLY48 4.9 40.8 1.0 C A:THR75 4.9 25.8 1.0 SG A:CYS52 4.9 60.1 1.0 N A:GLY53 4.9 19.6 1.0 N A:ALA76 4.9 24.2 1.0 C A:GLY50 4.9 36.9 1.0

Iron binding site 5 out of 16 in the Crystal Structure of the Mouse Liver Aldehyde Oxidase 3 (MAOX3)


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 5 of Crystal Structure of the Mouse Liver Aldehyde Oxidase 3 (MAOX3) within 5.0Å range: probe atom residue distance (Å) B Occ B:Fe3001 b:22.7 occ:1.00 FE1 B:FES3001 0.0 22.7 1.0 SG B:CYS152 2.1 32.4 1.0 S1 B:FES3001 2.2 26.9 1.0 S2 B:FES3001 2.2 7.3 1.0 SG B:CYS120 2.3 20.6 1.0 FE2 B:FES3001 3.0 20.0 1.0 CB B:CYS120 3.2 19.6 1.0 CB B:CYS152 3.3 34.9 1.0 CA B:CYS152 3.8 34.4 1.0 N B:ARG153 4.2 26.5 1.0 CA B:CYS120 4.3 15.3 1.0 N B:CYS120 4.3 21.0 1.0 C B:CYS152 4.5 32.7 1.0 SG B:CYS154 4.6 29.1 1.0 CG2 B:THR155 4.6 14.8 1.0 N B:CYS154 4.6 36.3 1.0 CB B:CYS154 4.7 30.9 1.0 SG B:CYS117 4.8 25.1 1.0 C B:CYS120 4.8 17.4 1.0 O B:LEU151 4.9 36.5 1.0

Iron binding site 6 out of 16 in the Crystal Structure of the Mouse Liver Aldehyde Oxidase 3 (MAOX3)


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 6 of Crystal Structure of the Mouse Liver Aldehyde Oxidase 3 (MAOX3) within 5.0Å range: probe atom residue distance (Å) B Occ B:Fe3001 b:20.0 occ:1.00 FE2 B:FES3001 0.0 20.0 1.0 SG B:CYS117 2.0 25.1 1.0 S1 B:FES3001 2.2 26.9 1.0 S2 B:FES3001 2.2 7.3 1.0 SG B:CYS154 2.4 29.1 1.0 FE1 B:FES3001 3.0 22.7 1.0 CB B:CYS117 3.1 34.2 1.0 O B:HOH2026 3.2 6.8 1.0 CB B:CYS154 3.6 30.9 1.0 N B:CYS117 3.8 21.5 1.0 CA B:CYS117 3.9 28.9 1.0 N B:GLY118 4.0 21.2 1.0 C B:CYS117 4.3 23.7 1.0 N B:CYS154 4.4 36.3 1.0 SG B:CYS152 4.5 32.4 1.0 N B:PHE119 4.5 22.6 1.0 CA B:CYS154 4.6 28.7 1.0 N B:CYS120 4.8 21.0 1.0 SG B:CYS120 4.8 20.6 1.0 CB B:CYS120 4.9 19.6 1.0 N B:ARG153 4.9 26.5 1.0 C B:GLN116 5.0 27.5 1.0

Iron binding site 7 out of 16 in the Crystal Structure of the Mouse Liver Aldehyde Oxidase 3 (MAOX3)


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 7 of Crystal Structure of the Mouse Liver Aldehyde Oxidase 3 (MAOX3) within 5.0Å range: probe atom residue distance (Å) B Occ B:Fe3002 b:38.3 occ:1.00 FE1 B:FES3002 0.0 38.3 1.0 S1 B:FES3002 2.2 20.5 1.0 S2 B:FES3002 2.2 21.7 1.0 SG B:CYS52 2.2 58.7 1.0 SG B:CYS47 2.5 61.0 1.0 FE2 B:FES3002 3.0 34.0 1.0 N B:GLY48 3.4 46.4 1.0 N B:CYS47 3.4 43.4 1.0 CB B:CYS52 3.7 29.8 1.0 CB B:CYS47 3.7 49.0 1.0 CA B:CYS47 3.9 48.8 1.0 N B:CYS52 3.9 34.9 1.0 C B:CYS47 4.0 53.2 1.0 CA B:CYS52 4.2 32.2 1.0 N B:GLY46 4.3 31.7 1.0 CA B:GLY48 4.3 42.2 1.0 N B:GLY53 4.3 15.7 1.0 C B:GLY46 4.4 39.0 1.0 N B:GLY50 4.4 41.7 1.0 N B:ASP51 4.4 38.1 1.0 C B:CYS52 4.5 27.9 1.0 N B:GLY49 4.6 38.6 1.0 N B:ALA54 4.6 12.3 1.0 SG B:CYS77 4.7 35.3 1.0 CA B:GLY46 4.8 35.1 1.0 SG B:CYS55 4.8 30.9 1.0 C B:GLY48 4.8 40.4 1.0 CA B:GLY50 4.8 38.1 1.0 CB B:ALA54 4.9 15.1 1.0

Iron binding site 8 out of 16 in the Crystal Structure of the Mouse Liver Aldehyde Oxidase 3 (MAOX3)


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 8 of Crystal Structure of the Mouse Liver Aldehyde Oxidase 3 (MAOX3) within 5.0Å range: probe atom residue distance (Å) B Occ B:Fe3002 b:34.0 occ:1.00 FE2 B:FES3002 0.0 34.0 1.0 S2 B:FES3002 2.2 21.7 1.0 S1 B:FES3002 2.2 20.5 1.0 SG B:CYS55 2.3 30.9 1.0 SG B:CYS77 2.3 35.3 1.0 FE1 B:FES3002 3.0 38.3 1.0 CB B:CYS77 3.5 26.1 1.0 CB B:CYS55 3.7 19.0 1.0 CG2 B:THR75 4.0 20.8 1.0 CA B:GLY50 4.0 38.1 1.0 CB B:THR75 4.1 21.4 1.0 N B:GLY50 4.1 41.7 1.0 N B:CYS77 4.4 31.3 1.0 N B:CYS55 4.4 12.8 1.0 CA B:GLY48 4.5 42.2 1.0 N B:GLY48 4.6 46.4 1.0 CA B:CYS77 4.6 28.7 1.0 CA B:CYS55 4.7 13.3 1.0 SG B:CYS52 4.7 58.7 1.0 C B:GLY48 4.8 40.4 1.0 N B:GLY53 4.8 15.7 1.0 CA B:THR75 4.8 24.6 1.0 C B:GLY50 4.9 35.8 1.0 SG B:CYS47 4.9 61.0 1.0

Iron binding site 9 out of 16 in the Crystal Structure of the Mouse Liver Aldehyde Oxidase 3 (MAOX3)


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 9 of Crystal Structure of the Mouse Liver Aldehyde Oxidase 3 (MAOX3) within 5.0Å range: probe atom residue distance (Å) B Occ C:Fe3001 b:24.4 occ:1.00 FE1 C:FES3001 0.0 24.4 1.0 S1 C:FES3001 2.2 25.0 1.0 S2 C:FES3001 2.2 39.1 1.0 SG C:CYS152 2.3 31.6 1.0 SG C:CYS120 2.4 27.5 1.0 FE2 C:FES3001 3.1 31.7 1.0 CB C:CYS120 3.3 27.6 1.0 CB C:CYS152 3.6 34.4 1.0 CA C:CYS152 4.1 33.8 1.0 N C:CYS120 4.2 27.0 1.0 CA C:CYS120 4.3 26.6 1.0 N C:ARG153 4.4 33.0 1.0 CG2 C:THR155 4.5 30.8 1.0 SG C:CYS154 4.5 33.3 1.0 CB C:CYS154 4.5 33.5 1.0 SG C:CYS117 4.6 30.7 1.0 N C:CYS154 4.6 36.5 1.0 C C:CYS152 4.7 32.8 1.0 C C:CYS120 4.8 25.6 1.0

Iron binding site 10 out of 16 in the Crystal Structure of the Mouse Liver Aldehyde Oxidase 3 (MAOX3)


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 10 of Crystal Structure of the Mouse Liver Aldehyde Oxidase 3 (MAOX3) within 5.0Å range: probe atom residue distance (Å) B Occ C:Fe3001 b:31.7 occ:1.00 FE2 C:FES3001 0.0 31.7 1.0 SG C:CYS117 2.1 30.7 1.0 S1 C:FES3001 2.2 25.0 1.0 S2 C:FES3001 2.2 39.1 1.0 SG C:CYS154 2.3 33.3 1.0 CB C:CYS117 2.7 34.7 1.0 FE1 C:FES3001 3.1 24.4 1.0 N C:CYS117 3.3 30.9 1.0 CB C:CYS154 3.4 33.5 1.0 CA C:CYS117 3.5 31.2 1.0 N C:GLY118 3.9 28.7 1.0 O C:HOH2096 3.9 33.0 1.0 C C:CYS117 4.0 29.6 1.0 N C:CYS154 4.4 36.5 1.0 CA C:CYS154 4.5 34.5 1.0 N C:PHE119 4.5 27.8 1.0 C C:GLN116 4.6 30.6 1.0 SG C:CYS152 4.7 31.6 1.0 CB C:GLN116 4.9 32.1 1.0

C.Coelho, M.Mahro, J.Trincao, A.T.P.Carvalho, M.J.Ramos, M.Terao, E.Garattini, S.Leimkuhler, M.J.Romao. The First Mammalian Aldehyde Oxidase Crystal Structure: Insights Into Substrate Specificity. J.Biol.Chem. V. 287 40690 2012.
ISSN: ISSN 0021-9258
PubMed: 23019336
DOI: 10.1074/JBC.M112.390419