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Atomistry » Iron » PDB 4ccx-4cun » 4cty | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Iron » PDB 4ccx-4cun » 4cty » |
Iron in PDB 4cty: Structure of Bovine Endothelial Nitric Oxide Synthase Heme Domain in Complex with (R)-6-(2-Amino-2-(3-(2-(6-Amino-4-Methylpyridin- 2-Yl)Ethyl)Phenyl)Ethyl)-4-Methylpyridin-2-AmineEnzymatic activity of Structure of Bovine Endothelial Nitric Oxide Synthase Heme Domain in Complex with (R)-6-(2-Amino-2-(3-(2-(6-Amino-4-Methylpyridin- 2-Yl)Ethyl)Phenyl)Ethyl)-4-Methylpyridin-2-Amine
All present enzymatic activity of Structure of Bovine Endothelial Nitric Oxide Synthase Heme Domain in Complex with (R)-6-(2-Amino-2-(3-(2-(6-Amino-4-Methylpyridin- 2-Yl)Ethyl)Phenyl)Ethyl)-4-Methylpyridin-2-Amine:
1.14.13.39; Protein crystallography data
The structure of Structure of Bovine Endothelial Nitric Oxide Synthase Heme Domain in Complex with (R)-6-(2-Amino-2-(3-(2-(6-Amino-4-Methylpyridin- 2-Yl)Ethyl)Phenyl)Ethyl)-4-Methylpyridin-2-Amine, PDB code: 4cty
was solved by
G.Chreifi,
H.Li,
T.L.Poulos,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 4cty:
The structure of Structure of Bovine Endothelial Nitric Oxide Synthase Heme Domain in Complex with (R)-6-(2-Amino-2-(3-(2-(6-Amino-4-Methylpyridin- 2-Yl)Ethyl)Phenyl)Ethyl)-4-Methylpyridin-2-Amine also contains other interesting chemical elements:
Iron Binding Sites:
The binding sites of Iron atom in the Structure of Bovine Endothelial Nitric Oxide Synthase Heme Domain in Complex with (R)-6-(2-Amino-2-(3-(2-(6-Amino-4-Methylpyridin- 2-Yl)Ethyl)Phenyl)Ethyl)-4-Methylpyridin-2-Amine
(pdb code 4cty). This binding sites where shown within
5.0 Angstroms radius around Iron atom.
In total 2 binding sites of Iron where determined in the Structure of Bovine Endothelial Nitric Oxide Synthase Heme Domain in Complex with (R)-6-(2-Amino-2-(3-(2-(6-Amino-4-Methylpyridin- 2-Yl)Ethyl)Phenyl)Ethyl)-4-Methylpyridin-2-Amine, PDB code: 4cty: Jump to Iron binding site number: 1; 2; Iron binding site 1 out of 2 in 4ctyGo back to![]() ![]()
Iron binding site 1 out
of 2 in the Structure of Bovine Endothelial Nitric Oxide Synthase Heme Domain in Complex with (R)-6-(2-Amino-2-(3-(2-(6-Amino-4-Methylpyridin- 2-Yl)Ethyl)Phenyl)Ethyl)-4-Methylpyridin-2-Amine
![]() Mono view ![]() Stereo pair view
Iron binding site 2 out of 2 in 4ctyGo back to![]() ![]()
Iron binding site 2 out
of 2 in the Structure of Bovine Endothelial Nitric Oxide Synthase Heme Domain in Complex with (R)-6-(2-Amino-2-(3-(2-(6-Amino-4-Methylpyridin- 2-Yl)Ethyl)Phenyl)Ethyl)-4-Methylpyridin-2-Amine
![]() Mono view ![]() Stereo pair view
Reference:
S.Kang,
W.Tang,
H.Li,
G.Chreifi,
P.Martasek,
L.J.Roman,
T.L.Poulos,
R.B.Silverman.
Nitric Oxide Synthase Inhibitors That Interact with Both A Heme Propionate and Tetrahydrobiopterin Show High Isoform Selectivity. J.Med.Chem. V. 57 4382 2014.
Page generated: Mon Aug 5 00:41:48 2024
ISSN: ISSN 0022-2623 PubMed: 24758147 DOI: 10.1021/JM5004182 |
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