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Iron in PDB 4jsf: Structure of Rat Neuronal Nitric Oxide Synthase Heme Domain in Complex with 6,6'-(Heptane-1,7-Diyl)Bis(4-Methylpyridin-2-Amine)
Enzymatic activity of Structure of Rat Neuronal Nitric Oxide Synthase Heme Domain in Complex with 6,6'-(Heptane-1,7-Diyl)Bis(4-Methylpyridin-2-Amine)
All present enzymatic activity of Structure of Rat Neuronal Nitric Oxide Synthase Heme Domain in Complex with 6,6'-(Heptane-1,7-Diyl)Bis(4-Methylpyridin-2-Amine):
1.14.13.39;
1.14.13.39;
Protein crystallography data
The structure of Structure of Rat Neuronal Nitric Oxide Synthase Heme Domain in Complex with 6,6'-(Heptane-1,7-Diyl)Bis(4-Methylpyridin-2-Amine), PDB code: 4jsf
was solved by
H.Li,
T.L.Poulos,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 40.75 / 2.05 |
| Space group | P 21 21 21 |
| Cell size a, b, c (Å), α, β, γ (°) | 51.827, 110.541, 164.288, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 17.5 / 21.7 |
Other elements in 4jsf:
The structure of Structure of Rat Neuronal Nitric Oxide Synthase Heme Domain in Complex with 6,6'-(Heptane-1,7-Diyl)Bis(4-Methylpyridin-2-Amine) also contains other interesting chemical elements:
| Zinc | (Zn) | 1 atom |
Iron Binding Sites:
The binding sites of Iron atom in the Structure of Rat Neuronal Nitric Oxide Synthase Heme Domain in Complex with 6,6'-(Heptane-1,7-Diyl)Bis(4-Methylpyridin-2-Amine)
(pdb code 4jsf). This binding sites where shown within
5.0 Angstroms radius around Iron atom.
In total 2 binding sites of Iron where determined in the Structure of Rat Neuronal Nitric Oxide Synthase Heme Domain in Complex with 6,6'-(Heptane-1,7-Diyl)Bis(4-Methylpyridin-2-Amine), PDB code: 4jsf:
Jump to Iron binding site number: 1; 2;
In total 2 binding sites of Iron where determined in the Structure of Rat Neuronal Nitric Oxide Synthase Heme Domain in Complex with 6,6'-(Heptane-1,7-Diyl)Bis(4-Methylpyridin-2-Amine), PDB code: 4jsf:
Jump to Iron binding site number: 1; 2;
Iron binding site 1 out of 2 in 4jsf
Go back to
Iron Binding Sites List in 4jsf
Iron binding site 1 out
of 2 in the Structure of Rat Neuronal Nitric Oxide Synthase Heme Domain in Complex with 6,6'-(Heptane-1,7-Diyl)Bis(4-Methylpyridin-2-Amine)
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Iron with other atoms in the Fe binding
site number 1 of Structure of Rat Neuronal Nitric Oxide Synthase Heme Domain in Complex with 6,6'-(Heptane-1,7-Diyl)Bis(4-Methylpyridin-2-Amine) within 5.0Å range:
|
Iron binding site 2 out of 2 in 4jsf
Go back to
Iron Binding Sites List in 4jsf
Iron binding site 2 out
of 2 in the Structure of Rat Neuronal Nitric Oxide Synthase Heme Domain in Complex with 6,6'-(Heptane-1,7-Diyl)Bis(4-Methylpyridin-2-Amine)
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Iron with other atoms in the Fe binding
site number 2 of Structure of Rat Neuronal Nitric Oxide Synthase Heme Domain in Complex with 6,6'-(Heptane-1,7-Diyl)Bis(4-Methylpyridin-2-Amine) within 5.0Å range:
|
Reference:
Q.Jing,
H.Li,
J.Fang,
L.J.Roman,
P.Martasek,
T.L.Poulos,
R.B.Silverman.
In Search of Potent and Selective Inhibitors of Neuronal Nitric Oxide Synthase with More Simple Structures. Bioorg.Med.Chem. V. 21 5323 2013.
ISSN: ISSN 0968-0896
PubMed: 23867386
DOI: 10.1016/J.BMC.2013.06.014
Page generated: Mon Aug 5 04:51:13 2024
ISSN: ISSN 0968-0896
PubMed: 23867386
DOI: 10.1016/J.BMC.2013.06.014
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