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Atomistry » Iron » PDB 4k5e-4kf2 » 4kcp | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Iron » PDB 4k5e-4kf2 » 4kcp » |
Iron in PDB 4kcp: Structure of Bovine Endotheial Nitric Oxide Synthase Heme Domain in Complex with N-(4-(2-((3-(Thiophene-2-Carboximidamido)Benzyl)Amino) Ethyl)Phenyl)Thiophene-2-CarboximidamideEnzymatic activity of Structure of Bovine Endotheial Nitric Oxide Synthase Heme Domain in Complex with N-(4-(2-((3-(Thiophene-2-Carboximidamido)Benzyl)Amino) Ethyl)Phenyl)Thiophene-2-Carboximidamide
All present enzymatic activity of Structure of Bovine Endotheial Nitric Oxide Synthase Heme Domain in Complex with N-(4-(2-((3-(Thiophene-2-Carboximidamido)Benzyl)Amino) Ethyl)Phenyl)Thiophene-2-Carboximidamide:
1.14.13.39; Protein crystallography data
The structure of Structure of Bovine Endotheial Nitric Oxide Synthase Heme Domain in Complex with N-(4-(2-((3-(Thiophene-2-Carboximidamido)Benzyl)Amino) Ethyl)Phenyl)Thiophene-2-Carboximidamide, PDB code: 4kcp
was solved by
G.Chreifi,
H.Li,
T.L.Poulos,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 4kcp:
The structure of Structure of Bovine Endotheial Nitric Oxide Synthase Heme Domain in Complex with N-(4-(2-((3-(Thiophene-2-Carboximidamido)Benzyl)Amino) Ethyl)Phenyl)Thiophene-2-Carboximidamide also contains other interesting chemical elements:
Iron Binding Sites:
The binding sites of Iron atom in the Structure of Bovine Endotheial Nitric Oxide Synthase Heme Domain in Complex with N-(4-(2-((3-(Thiophene-2-Carboximidamido)Benzyl)Amino) Ethyl)Phenyl)Thiophene-2-Carboximidamide
(pdb code 4kcp). This binding sites where shown within
5.0 Angstroms radius around Iron atom.
In total 2 binding sites of Iron where determined in the Structure of Bovine Endotheial Nitric Oxide Synthase Heme Domain in Complex with N-(4-(2-((3-(Thiophene-2-Carboximidamido)Benzyl)Amino) Ethyl)Phenyl)Thiophene-2-Carboximidamide, PDB code: 4kcp: Jump to Iron binding site number: 1; 2; Iron binding site 1 out of 2 in 4kcpGo back to Iron Binding Sites List in 4kcp
Iron binding site 1 out
of 2 in the Structure of Bovine Endotheial Nitric Oxide Synthase Heme Domain in Complex with N-(4-(2-((3-(Thiophene-2-Carboximidamido)Benzyl)Amino) Ethyl)Phenyl)Thiophene-2-Carboximidamide
Mono view Stereo pair view
Iron binding site 2 out of 2 in 4kcpGo back to Iron Binding Sites List in 4kcp
Iron binding site 2 out
of 2 in the Structure of Bovine Endotheial Nitric Oxide Synthase Heme Domain in Complex with N-(4-(2-((3-(Thiophene-2-Carboximidamido)Benzyl)Amino) Ethyl)Phenyl)Thiophene-2-Carboximidamide
Mono view Stereo pair view
Reference:
H.Huang,
H.Li,
S.Yang,
G.Chreifi,
P.Martasek,
L.J.Roman,
F.L.Meyskens,
T.L.Poulos,
R.B.Silverman.
Potent and Selective Double-Headed Thiophene-2-Carboximidamide Inhibitors of Neuronal Nitric Oxide Synthase For the Treatment of Melanoma. J.Med.Chem. V. 57 686 2014.
Page generated: Mon Aug 5 05:22:11 2024
ISSN: ISSN 0022-2623 PubMed: 24447275 DOI: 10.1021/JM401252E |
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