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Iron in PDB 4klr: E343Q Variant of Human Ferrochelatase

Enzymatic activity of E343Q Variant of Human Ferrochelatase

All present enzymatic activity of E343Q Variant of Human Ferrochelatase:
4.99.1.1;

Protein crystallography data

The structure of E343Q Variant of Human Ferrochelatase, PDB code: 4klr was solved by W.N.Lanzilotta, A.E.Medlock, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 70.71 / 2.18
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 86.127, 92.561, 109.262, 90.00, 90.00, 90.00
R / Rfree (%) 20 / 25.8

Other elements in 4klr:

The structure of E343Q Variant of Human Ferrochelatase also contains other interesting chemical elements:

Chlorine (Cl) 1 atom

Iron Binding Sites:

The binding sites of Iron atom in the E343Q Variant of Human Ferrochelatase (pdb code 4klr). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total 6 binding sites of Iron where determined in the E343Q Variant of Human Ferrochelatase, PDB code: 4klr:
Jump to Iron binding site number: 1; 2; 3; 4; 5; 6;

Iron binding site 1 out of 6 in 4klr

Go back to Iron Binding Sites List in 4klr
Iron binding site 1 out of 6 in the E343Q Variant of Human Ferrochelatase


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of E343Q Variant of Human Ferrochelatase within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Fe507

b:18.9
occ:1.00
 FE A:HEM507 0.0 18.9 1.0
ND A:HEM507 1.9 18.6 1.0
N1 A:IMD501 1.9 27.0 1.0
NB A:HEM507 2.0 22.8 1.0
NC A:HEM507 2.1 20.2 1.0
NA A:HEM507 2.1 25.6 1.0
O2 A:BCT502 2.4 36.0 1.0
C5 A:IMD501 2.9 28.3 1.0
C1D A:HEM507 2.9 23.1 1.0
C4B A:HEM507 3.0 20.7 1.0
C4D A:HEM507 3.0 20.9 1.0
C1C A:HEM507 3.0 17.5 1.0
C2 A:IMD501 3.0 26.4 1.0
C1B A:HEM507 3.0 25.0 1.0
C1A A:HEM507 3.1 24.5 1.0
C4C A:HEM507 3.1 16.5 1.0
C4A A:HEM507 3.1 28.4 1.0
CHC A:HEM507 3.3 19.4 1.0
CHD A:HEM507 3.4 21.1 1.0
CHA A:HEM507 3.4 19.4 1.0
CHB A:HEM507 3.5 26.2 1.0
C A:BCT502 3.7 38.8 1.0
C4 A:IMD501 4.1 27.2 1.0
N3 A:IMD501 4.1 26.5 1.0
C3B A:HEM507 4.2 22.1 1.0
C2D A:HEM507 4.2 22.1 1.0
C3D A:HEM507 4.2 19.0 1.0
C2B A:HEM507 4.2 23.6 1.0
C2C A:HEM507 4.3 16.5 1.0
C3C A:HEM507 4.3 17.1 1.0
O3 A:BCT502 4.3 36.6 1.0
C2A A:HEM507 4.3 28.4 1.0
C3A A:HEM507 4.3 25.6 1.0
O1 A:BCT502 4.6 40.1 1.0
CE A:MET76 4.8 33.3 1.0

Iron binding site 2 out of 6 in 4klr

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Iron binding site 2 out of 6 in the E343Q Variant of Human Ferrochelatase


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 2 of E343Q Variant of Human Ferrochelatase within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Fe508

b:26.3
occ:1.00
 FE1 A:FES508 0.0 26.3 1.0
S1 A:FES508 2.2 26.4 1.0
S2 A:FES508 2.2 28.3 1.0
SG A:CYS411 2.3 27.7 1.0
SG A:CYS406 2.4 31.4 1.0
FE2 A:FES508 2.8 26.4 1.0
CB A:CYS411 3.2 27.9 1.0
CB A:CYS406 3.4 28.6 1.0
O A:HOH708 4.1 26.5 1.0
O A:HOH624 4.2 30.0 1.0
CB A:ASN408 4.3 34.0 1.0
CA A:CYS406 4.3 29.5 1.0
SG A:CYS196 4.4 28.9 1.0
O A:ASN408 4.6 32.4 1.0
CA A:CYS411 4.6 27.1 1.0
CB A:CYS196 4.8 21.1 1.0
SG A:CYS403 4.8 25.1 1.0
N A:ASN408 4.8 33.5 1.0
OG A:SER402 4.9 33.7 1.0
N A:CYS403 4.9 23.8 1.0
CB A:CYS403 5.0 25.4 1.0

Iron binding site 3 out of 6 in 4klr

Go back to Iron Binding Sites List in 4klr
Iron binding site 3 out of 6 in the E343Q Variant of Human Ferrochelatase


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 3 of E343Q Variant of Human Ferrochelatase within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Fe508

b:26.4
occ:1.00
 FE2 A:FES508 0.0 26.4 1.0
S2 A:FES508 2.2 28.3 1.0
S1 A:FES508 2.3 26.4 1.0
SG A:CYS196 2.3 28.9 1.0
SG A:CYS403 2.3 25.1 1.0
FE1 A:FES508 2.8 26.3 1.0
CB A:CYS403 3.3 25.4 1.0
CB A:CYS196 3.5 21.1 1.0
O A:HOH649 3.7 29.1 1.0
O A:HOH707 3.8 39.9 1.0
N A:CYS403 3.8 23.8 1.0
CA A:CYS403 4.2 24.5 1.0
CB A:CYS406 4.5 28.6 1.0
SG A:CYS406 4.6 31.4 1.0
SG A:CYS411 4.6 27.7 1.0
CA A:CYS196 4.8 20.7 1.0
NH1 A:ARG272 5.0 36.8 1.0
C A:SER402 5.0 24.7 1.0

Iron binding site 4 out of 6 in 4klr

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Iron binding site 4 out of 6 in the E343Q Variant of Human Ferrochelatase


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 4 of E343Q Variant of Human Ferrochelatase within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Fe506

b:17.1
occ:1.00
 FE B:HEM506 0.0 17.1 1.0
ND B:HEM506 1.9 14.8 1.0
NB B:HEM506 2.0 21.8 1.0
N1 B:IMD501 2.0 23.2 1.0
NA B:HEM506 2.1 23.9 1.0
NC B:HEM506 2.1 18.9 1.0
O1 B:BCT502 2.4 37.3 1.0
C1D B:HEM506 2.9 18.7 1.0
C4D B:HEM506 3.0 17.9 1.0
C5 B:IMD501 3.0 23.6 1.0
C4B B:HEM506 3.0 19.7 1.0
C1B B:HEM506 3.0 24.2 1.0
C4A B:HEM506 3.1 24.1 1.0
C1A B:HEM506 3.1 21.1 1.0
C1C B:HEM506 3.1 15.9 1.0
C2 B:IMD501 3.1 21.4 1.0
C4C B:HEM506 3.1 12.5 1.0
CHC B:HEM506 3.4 18.0 1.0
CHD B:HEM506 3.4 15.2 1.0
CHA B:HEM506 3.4 16.2 1.0
CHB B:HEM506 3.4 24.9 1.0
C B:BCT502 3.7 39.7 1.0
C2D B:HEM506 4.2 19.6 1.0
C3D B:HEM506 4.2 15.9 1.0
C4 B:IMD501 4.2 25.5 1.0
N3 B:IMD501 4.2 25.4 1.0
C3B B:HEM506 4.2 22.7 1.0
C2B B:HEM506 4.2 22.9 1.0
C3A B:HEM506 4.3 23.9 1.0
C2A B:HEM506 4.3 24.6 1.0
C2C B:HEM506 4.3 16.0 1.0
O2 B:BCT502 4.3 41.1 1.0
C3C B:HEM506 4.4 13.9 1.0
O3 B:BCT502 4.7 38.7 1.0
CE B:MET76 4.9 35.1 1.0

Iron binding site 5 out of 6 in 4klr

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Iron binding site 5 out of 6 in the E343Q Variant of Human Ferrochelatase


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 5 of E343Q Variant of Human Ferrochelatase within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Fe507

b:25.4
occ:1.00
 FE1 B:FES507 0.0 25.4 1.0
S1 B:FES507 2.2 26.4 1.0
S2 B:FES507 2.2 25.9 1.0
SG B:CYS411 2.3 24.9 1.0
SG B:CYS406 2.4 29.3 1.0
FE2 B:FES507 2.8 25.7 1.0
CB B:CYS411 3.2 24.0 1.0
CB B:CYS406 3.3 28.6 1.0
O B:HOH661 4.1 27.1 1.0
CA B:CYS406 4.2 29.6 1.0
O B:HOH747 4.2 46.5 1.0
O B:HOH734 4.2 21.9 1.0
CB B:ASN408 4.4 31.0 1.0
SG B:CYS196 4.4 27.1 1.0
O B:ASN408 4.5 28.2 1.0
CA B:CYS411 4.6 25.2 1.0
SG B:CYS403 4.8 26.0 1.0
CB B:CYS196 4.9 20.6 1.0
N B:CYS403 4.9 23.1 1.0
CB B:CYS403 4.9 23.7 1.0
N B:ASN408 4.9 31.1 1.0
O B:HOH735 4.9 48.2 1.0

Iron binding site 6 out of 6 in 4klr

Go back to Iron Binding Sites List in 4klr
Iron binding site 6 out of 6 in the E343Q Variant of Human Ferrochelatase


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 6 of E343Q Variant of Human Ferrochelatase within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Fe507

b:25.7
occ:1.00
 FE2 B:FES507 0.0 25.7 1.0
S2 B:FES507 2.2 25.9 1.0
S1 B:FES507 2.3 26.4 1.0
SG B:CYS196 2.3 27.1 1.0
SG B:CYS403 2.4 26.0 1.0
FE1 B:FES507 2.8 25.4 1.0
CB B:CYS403 3.3 23.7 1.0
CB B:CYS196 3.4 20.6 1.0
O B:HOH623 3.5 30.6 1.0
O B:HOH747 3.7 46.5 1.0
N B:CYS403 3.9 23.1 1.0
CA B:CYS403 4.2 23.5 1.0
CB B:CYS406 4.5 28.6 1.0
SG B:CYS411 4.6 24.9 1.0
SG B:CYS406 4.6 29.3 1.0
CA B:CYS196 4.8 18.6 1.0

Reference:

W.N.Lanzilotta, A.E.Medlock. E343Q Variant of Human Ferrochelatase To Be Published.
Page generated: Mon Aug 5 05:27:48 2024

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