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Iron in PDB 4uyl: Crystal Structure of Sterol 14-Alpha Demethylase (CYP51B) From A Pathogenic Filamentous Fungus Aspergillus Fumigatus in Complex with Vni
Enzymatic activity of Crystal Structure of Sterol 14-Alpha Demethylase (CYP51B) From A Pathogenic Filamentous Fungus Aspergillus Fumigatus in Complex with Vni
All present enzymatic activity of Crystal Structure of Sterol 14-Alpha Demethylase (CYP51B) From A Pathogenic Filamentous Fungus Aspergillus Fumigatus in Complex with Vni:
1.14.13.70;
1.14.13.70;
Protein crystallography data
The structure of Crystal Structure of Sterol 14-Alpha Demethylase (CYP51B) From A Pathogenic Filamentous Fungus Aspergillus Fumigatus in Complex with Vni, PDB code: 4uyl
was solved by
T.Y.Hargrove,
Z.Wawrzak,
G.I.Lepesheva,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 95.69 / 2.81 |
| Space group | P 31 |
| Cell size a, b, c (Å), α, β, γ (°) | 110.498, 110.498, 90.479, 90.00, 90.00, 120.00 |
| R / Rfree (%) | 23.702 / 27.917 |
Other elements in 4uyl:
The structure of Crystal Structure of Sterol 14-Alpha Demethylase (CYP51B) From A Pathogenic Filamentous Fungus Aspergillus Fumigatus in Complex with Vni also contains other interesting chemical elements:
| Chlorine | (Cl) | 4 atoms |
Iron Binding Sites:
The binding sites of Iron atom in the Crystal Structure of Sterol 14-Alpha Demethylase (CYP51B) From A Pathogenic Filamentous Fungus Aspergillus Fumigatus in Complex with Vni
(pdb code 4uyl). This binding sites where shown within
5.0 Angstroms radius around Iron atom.
In total 2 binding sites of Iron where determined in the Crystal Structure of Sterol 14-Alpha Demethylase (CYP51B) From A Pathogenic Filamentous Fungus Aspergillus Fumigatus in Complex with Vni, PDB code: 4uyl:
Jump to Iron binding site number: 1; 2;
In total 2 binding sites of Iron where determined in the Crystal Structure of Sterol 14-Alpha Demethylase (CYP51B) From A Pathogenic Filamentous Fungus Aspergillus Fumigatus in Complex with Vni, PDB code: 4uyl:
Jump to Iron binding site number: 1; 2;
Iron binding site 1 out of 2 in 4uyl
Go back to
Iron Binding Sites List in 4uyl
Iron binding site 1 out
of 2 in the Crystal Structure of Sterol 14-Alpha Demethylase (CYP51B) From A Pathogenic Filamentous Fungus Aspergillus Fumigatus in Complex with Vni
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Iron with other atoms in the Fe binding
site number 1 of Crystal Structure of Sterol 14-Alpha Demethylase (CYP51B) From A Pathogenic Filamentous Fungus Aspergillus Fumigatus in Complex with Vni within 5.0Å range:
|
Iron binding site 2 out of 2 in 4uyl
Go back to
Iron Binding Sites List in 4uyl
Iron binding site 2 out
of 2 in the Crystal Structure of Sterol 14-Alpha Demethylase (CYP51B) From A Pathogenic Filamentous Fungus Aspergillus Fumigatus in Complex with Vni
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Iron with other atoms in the Fe binding
site number 2 of Crystal Structure of Sterol 14-Alpha Demethylase (CYP51B) From A Pathogenic Filamentous Fungus Aspergillus Fumigatus in Complex with Vni within 5.0Å range:
|
Reference:
T.Y.Hargrove,
Z.Warwzak,
D.C.Lamb,
F.P.Guengerich,
G.I.Lepesheva.
Structure-Functional Characterization of Cytochrome P450 Sterol Alpha-Demethylase (CYP51B) From Aspergillus Fumigatus and Molecular Basis For the Development of Antifungal Drugs J.Biol.Chem. V. 290 23916 2015.
ISSN: ISSN 0021-9258
PubMed: 26269599
DOI: 10.1074/JBC.M115.677310
Page generated: Mon Aug 5 14:06:47 2024
ISSN: ISSN 0021-9258
PubMed: 26269599
DOI: 10.1074/JBC.M115.677310
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