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Atomistry » Iron » PDB 4ur2-4wgz » 4uym » |
Iron in PDB 4uym: Crystal Structure of Sterol 14-Alpha Demethylase (CYP51B) From A Pathogenic Filamentous Fungus Aspergillus Fumigatus in Complex with VoriconazoleEnzymatic activity of Crystal Structure of Sterol 14-Alpha Demethylase (CYP51B) From A Pathogenic Filamentous Fungus Aspergillus Fumigatus in Complex with Voriconazole
All present enzymatic activity of Crystal Structure of Sterol 14-Alpha Demethylase (CYP51B) From A Pathogenic Filamentous Fungus Aspergillus Fumigatus in Complex with Voriconazole:
1.14.13.70; Protein crystallography data
The structure of Crystal Structure of Sterol 14-Alpha Demethylase (CYP51B) From A Pathogenic Filamentous Fungus Aspergillus Fumigatus in Complex with Voriconazole, PDB code: 4uym
was solved by
T.Y.Hargrove,
Z.Wawrzak,
G.I.Lepesheva,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 4uym:
The structure of Crystal Structure of Sterol 14-Alpha Demethylase (CYP51B) From A Pathogenic Filamentous Fungus Aspergillus Fumigatus in Complex with Voriconazole also contains other interesting chemical elements:
Iron Binding Sites:
The binding sites of Iron atom in the Crystal Structure of Sterol 14-Alpha Demethylase (CYP51B) From A Pathogenic Filamentous Fungus Aspergillus Fumigatus in Complex with Voriconazole
(pdb code 4uym). This binding sites where shown within
5.0 Angstroms radius around Iron atom.
In total 2 binding sites of Iron where determined in the Crystal Structure of Sterol 14-Alpha Demethylase (CYP51B) From A Pathogenic Filamentous Fungus Aspergillus Fumigatus in Complex with Voriconazole, PDB code: 4uym: Jump to Iron binding site number: 1; 2; Iron binding site 1 out of 2 in 4uymGo back to Iron Binding Sites List in 4uym
Iron binding site 1 out
of 2 in the Crystal Structure of Sterol 14-Alpha Demethylase (CYP51B) From A Pathogenic Filamentous Fungus Aspergillus Fumigatus in Complex with Voriconazole
Mono view Stereo pair view
Iron binding site 2 out of 2 in 4uymGo back to Iron Binding Sites List in 4uym
Iron binding site 2 out
of 2 in the Crystal Structure of Sterol 14-Alpha Demethylase (CYP51B) From A Pathogenic Filamentous Fungus Aspergillus Fumigatus in Complex with Voriconazole
Mono view Stereo pair view
Reference:
T.Y.Hargrove,
Z.Warwzak,
D.C.Lamb,
F.P.Guengerich,
G.I.Lepesheva.
Structure-Functional Characterization of Cytochrome P450 Sterol Alpha-Demethylase (CYP51B) From Aspergillus Fumigatus and Molecular Basis For the Development of Antifungal Drugs J.Biol.Chem. V. 290 23916 2015.
Page generated: Sun Dec 13 15:50:15 2020
ISSN: ISSN 0021-9258 PubMed: 26269599 DOI: 10.1074/JBC.M115.677310 |
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