Iron in PDB 4v06: Crystal Structure of Human Tryptophan Hydroxylase 2 (TPH2), Catalytic Domain

All present enzymatic activity of Crystal Structure of Human Tryptophan Hydroxylase 2 (TPH2), Catalytic Domain:
1.14.16.4;

The structure of Crystal Structure of Human Tryptophan Hydroxylase 2 (TPH2), Catalytic Domain, PDB code: 4v06 was solved by J.Kopec, A.Oberholzer, F.Fitzpatrick, J.Newman, C.Tallant, W.Kiyani, L.Shrestha, N.Burgess-Brown, F.Von Delft, C.Arrowsmith, A.Edwards, C.Bountra, W.W.Yue, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	44.504 / 2.63
Space group	P 21 21 2
Cell size a, b, c (Å), α, β, γ (°)	95.960, 100.199, 89.009, 90.00, 90.00, 90.00
R / Rfree (%)	19.77 / 24.24

The binding sites of Iron atom in the Crystal Structure of Human Tryptophan Hydroxylase 2 (TPH2), Catalytic Domain (pdb code 4v06). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total 2 binding sites of Iron where determined in the Crystal Structure of Human Tryptophan Hydroxylase 2 (TPH2), Catalytic Domain, PDB code: 4v06:
Jump to Iron binding site number: 1; 2;

Iron binding site 1 out of 2 in the Crystal Structure of Human Tryptophan Hydroxylase 2 (TPH2), Catalytic Domain


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Crystal Structure of Human Tryptophan Hydroxylase 2 (TPH2), Catalytic Domain within 5.0Å range: probe atom residue distance (Å) B Occ A:Fe1491 b:62.9 occ:1.00 N1 A:IMD600 1.9 88.2 1.0 OE2 A:GLU363 2.0 79.8 1.0 NE2 A:HIS323 2.1 67.0 1.0 NE2 A:HIS318 2.3 53.6 1.0 OE1 A:GLU363 2.6 64.8 1.0 CD A:GLU363 2.6 70.4 1.0 C5 A:IMD600 2.8 80.5 1.0 CE1 A:HIS323 3.0 55.8 1.0 C2 A:IMD600 3.0 94.9 1.0 CD2 A:HIS323 3.1 54.7 1.0 CE1 A:HIS318 3.2 56.6 1.0 CD2 A:HIS318 3.2 48.7 1.0 C4 A:IMD600 3.9 84.4 1.0 N3 A:IMD600 4.0 97.1 1.0 CG A:GLU363 4.1 63.1 1.0 ND1 A:HIS323 4.1 62.4 1.0 CG A:HIS323 4.2 42.6 1.0 CB A:ALA378 4.3 49.5 1.0 ND1 A:HIS318 4.4 62.5 1.0 CG A:HIS318 4.4 53.6 1.0 OH A:TYR358 4.4 61.0 1.0 OE1 A:GLU319 4.6 75.2 1.0 CZ A:PHE296 4.8 61.3 1.0 CB A:PRO314 5.0 50.1 1.0

Iron binding site 2 out of 2 in the Crystal Structure of Human Tryptophan Hydroxylase 2 (TPH2), Catalytic Domain


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 2 of Crystal Structure of Human Tryptophan Hydroxylase 2 (TPH2), Catalytic Domain within 5.0Å range: probe atom residue distance (Å) B Occ B:Fe1491 b:89.3 occ:1.00 N1 B:IMD600 1.9 87.2 1.0 NE2 B:HIS323 2.2 86.2 1.0 NE2 B:HIS318 2.3 0.6 1.0 OE2 B:GLU363 2.4 1.0 1.0 OE1 B:GLU363 2.4 91.8 1.0 CD B:GLU363 2.7 98.1 1.0 CE1 B:HIS323 2.8 74.3 1.0 C2 B:IMD600 2.8 79.8 1.0 C5 B:IMD600 2.9 94.4 1.0 CE1 B:HIS318 3.2 93.0 1.0 CD2 B:HIS318 3.3 97.0 1.0 CD2 B:HIS323 3.4 82.5 1.0 N3 B:IMD600 4.0 92.6 1.0 C4 B:IMD600 4.0 90.2 1.0 ND1 B:HIS323 4.1 85.2 1.0 CG B:GLU363 4.2 0.7 1.0 CB B:ALA378 4.3 83.2 1.0 ND1 B:HIS318 4.3 86.0 1.0 OH B:TYR358 4.3 0.1 1.0 CG B:HIS323 4.4 81.2 1.0 CG B:HIS318 4.4 87.5 1.0 CZ B:PHE296 4.9 81.5 1.0 CB B:GLU363 4.9 88.1 1.0

J.Kopec, A.Oberholzer, F.Fitzpatrick, J.Newman, C.Tallant, L.Shrestha, N.Burgess-Brown, F.Von Delft, C.Arrowsmith, A.Edwards, C.Bountra, W.W.Yue. Crystal Structure of Human Tryptophane Hydroxylase 2 (TPH2), Catalytic Domain To Be Published.