Atomistry » Iron » PDB 4ur2-4wgz » 4v06
Atomistry »
  Iron »
    PDB 4ur2-4wgz »
      4v06 »

Iron in PDB 4v06: Crystal Structure of Human Tryptophan Hydroxylase 2 (TPH2), Catalytic Domain

Enzymatic activity of Crystal Structure of Human Tryptophan Hydroxylase 2 (TPH2), Catalytic Domain

All present enzymatic activity of Crystal Structure of Human Tryptophan Hydroxylase 2 (TPH2), Catalytic Domain:
1.14.16.4;

Protein crystallography data

The structure of Crystal Structure of Human Tryptophan Hydroxylase 2 (TPH2), Catalytic Domain, PDB code: 4v06 was solved by J.Kopec, A.Oberholzer, F.Fitzpatrick, J.Newman, C.Tallant, W.Kiyani, L.Shrestha, N.Burgess-Brown, F.Von Delft, C.Arrowsmith, A.Edwards, C.Bountra, W.W.Yue, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 44.504 / 2.63
Space group P 21 21 2
Cell size a, b, c (Å), α, β, γ (°) 95.960, 100.199, 89.009, 90.00, 90.00, 90.00
R / Rfree (%) 19.77 / 24.24

Iron Binding Sites:

The binding sites of Iron atom in the Crystal Structure of Human Tryptophan Hydroxylase 2 (TPH2), Catalytic Domain (pdb code 4v06). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total 2 binding sites of Iron where determined in the Crystal Structure of Human Tryptophan Hydroxylase 2 (TPH2), Catalytic Domain, PDB code: 4v06:
Jump to Iron binding site number: 1; 2;

Iron binding site 1 out of 2 in 4v06

Go back to Iron Binding Sites List in 4v06
Iron binding site 1 out of 2 in the Crystal Structure of Human Tryptophan Hydroxylase 2 (TPH2), Catalytic Domain


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Crystal Structure of Human Tryptophan Hydroxylase 2 (TPH2), Catalytic Domain within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Fe1491

b:62.9
occ:1.00
N1 A:IMD600 1.9 88.2 1.0
OE2 A:GLU363 2.0 79.8 1.0
NE2 A:HIS323 2.1 67.0 1.0
NE2 A:HIS318 2.3 53.6 1.0
OE1 A:GLU363 2.6 64.8 1.0
CD A:GLU363 2.6 70.4 1.0
C5 A:IMD600 2.8 80.5 1.0
CE1 A:HIS323 3.0 55.8 1.0
C2 A:IMD600 3.0 94.9 1.0
CD2 A:HIS323 3.1 54.7 1.0
CE1 A:HIS318 3.2 56.6 1.0
CD2 A:HIS318 3.2 48.7 1.0
C4 A:IMD600 3.9 84.4 1.0
N3 A:IMD600 4.0 97.1 1.0
CG A:GLU363 4.1 63.1 1.0
ND1 A:HIS323 4.1 62.4 1.0
CG A:HIS323 4.2 42.6 1.0
CB A:ALA378 4.3 49.5 1.0
ND1 A:HIS318 4.4 62.5 1.0
CG A:HIS318 4.4 53.6 1.0
OH A:TYR358 4.4 61.0 1.0
OE1 A:GLU319 4.6 75.2 1.0
CZ A:PHE296 4.8 61.3 1.0
CB A:PRO314 5.0 50.1 1.0

Iron binding site 2 out of 2 in 4v06

Go back to Iron Binding Sites List in 4v06
Iron binding site 2 out of 2 in the Crystal Structure of Human Tryptophan Hydroxylase 2 (TPH2), Catalytic Domain


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 2 of Crystal Structure of Human Tryptophan Hydroxylase 2 (TPH2), Catalytic Domain within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Fe1491

b:89.3
occ:1.00
N1 B:IMD600 1.9 87.2 1.0
NE2 B:HIS323 2.2 86.2 1.0
NE2 B:HIS318 2.3 0.6 1.0
OE2 B:GLU363 2.4 1.0 1.0
OE1 B:GLU363 2.4 91.8 1.0
CD B:GLU363 2.7 98.1 1.0
CE1 B:HIS323 2.8 74.3 1.0
C2 B:IMD600 2.8 79.8 1.0
C5 B:IMD600 2.9 94.4 1.0
CE1 B:HIS318 3.2 93.0 1.0
CD2 B:HIS318 3.3 97.0 1.0
CD2 B:HIS323 3.4 82.5 1.0
N3 B:IMD600 4.0 92.6 1.0
C4 B:IMD600 4.0 90.2 1.0
ND1 B:HIS323 4.1 85.2 1.0
CG B:GLU363 4.2 0.7 1.0
CB B:ALA378 4.3 83.2 1.0
ND1 B:HIS318 4.3 86.0 1.0
OH B:TYR358 4.3 0.1 1.0
CG B:HIS323 4.4 81.2 1.0
CG B:HIS318 4.4 87.5 1.0
CZ B:PHE296 4.9 81.5 1.0
CB B:GLU363 4.9 88.1 1.0

Reference:

J.Kopec, A.Oberholzer, F.Fitzpatrick, J.Newman, C.Tallant, L.Shrestha, N.Burgess-Brown, F.Von Delft, C.Arrowsmith, A.Edwards, C.Bountra, W.W.Yue. Crystal Structure of Human Tryptophane Hydroxylase 2 (TPH2), Catalytic Domain To Be Published.
Page generated: Sun Dec 13 15:50:19 2020

Last articles

Zn in 8WB0
Zn in 8WAX
Zn in 8WAU
Zn in 8WAZ
Zn in 8WAY
Zn in 8WAV
Zn in 8WAW
Zn in 8WAT
Zn in 8W7M
Zn in 8WD3
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy