Atomistry » Iron » PDB 5dab-5eax » 5den
Atomistry »
  Iron »
    PDB 5dab-5eax »
      5den »

Iron in PDB 5den: The First Structure of A Full-Length Mammalian Phenylalanine Hydroxylase Reveals the Architecture of An Auto-Inhibited Tetramer

Enzymatic activity of The First Structure of A Full-Length Mammalian Phenylalanine Hydroxylase Reveals the Architecture of An Auto-Inhibited Tetramer

All present enzymatic activity of The First Structure of A Full-Length Mammalian Phenylalanine Hydroxylase Reveals the Architecture of An Auto-Inhibited Tetramer:
1.14.16.1;

Protein crystallography data

The structure of The First Structure of A Full-Length Mammalian Phenylalanine Hydroxylase Reveals the Architecture of An Auto-Inhibited Tetramer, PDB code: 5den was solved by E.C.Arturo, P.J.Loll, E.K.Jaffe, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 38.10 / 2.90
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 113.780, 89.160, 196.810, 90.00, 104.53, 90.00
R / Rfree (%) 23.8 / 30.3

Iron Binding Sites:

The binding sites of Iron atom in the The First Structure of A Full-Length Mammalian Phenylalanine Hydroxylase Reveals the Architecture of An Auto-Inhibited Tetramer (pdb code 5den). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total 4 binding sites of Iron where determined in the The First Structure of A Full-Length Mammalian Phenylalanine Hydroxylase Reveals the Architecture of An Auto-Inhibited Tetramer, PDB code: 5den:
Jump to Iron binding site number: 1; 2; 3; 4;

Iron binding site 1 out of 4 in 5den

Go back to Iron Binding Sites List in 5den
Iron binding site 1 out of 4 in the The First Structure of A Full-Length Mammalian Phenylalanine Hydroxylase Reveals the Architecture of An Auto-Inhibited Tetramer


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of The First Structure of A Full-Length Mammalian Phenylalanine Hydroxylase Reveals the Architecture of An Auto-Inhibited Tetramer within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Fe501

b:59.1
occ:0.80
 OE2 A:GLU330 2.1 80.4 1.0
NE2 A:HIS285 2.2 81.0 1.0
NE2 A:HIS290 2.2 79.4 1.0
O A:HOH601 2.3 31.7 1.0
O A:HOH602 2.3 72.1 1.0
CE1 A:HIS290 2.8 78.7 1.0
CD A:GLU330 2.9 72.5 1.0
OE1 A:GLU330 3.1 86.8 1.0
CD2 A:HIS285 3.1 81.4 1.0
CE1 A:HIS285 3.2 73.8 1.0
CD2 A:HIS290 3.4 89.1 1.0
ND1 A:HIS290 4.0 83.6 1.0
OH A:TYR325 4.1 80.0 1.0
ND1 A:HIS285 4.3 51.0 1.0
CG A:HIS285 4.3 72.7 1.0
CG A:GLU330 4.3 75.9 1.0
CG A:HIS290 4.3 85.5 1.0
OE1 A:GLU286 4.5 72.5 1.0
CB A:ALA345 4.8 68.6 1.0
CG A:PRO281 5.0 68.6 1.0

Iron binding site 2 out of 4 in 5den

Go back to Iron Binding Sites List in 5den
Iron binding site 2 out of 4 in the The First Structure of A Full-Length Mammalian Phenylalanine Hydroxylase Reveals the Architecture of An Auto-Inhibited Tetramer


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 2 of The First Structure of A Full-Length Mammalian Phenylalanine Hydroxylase Reveals the Architecture of An Auto-Inhibited Tetramer within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Fe501

b:44.8
occ:0.55
 OE2 B:GLU330 2.1 88.2 1.0
NE2 B:HIS290 2.2 0.9 1.0
NE2 B:HIS285 2.2 95.2 1.0
O B:HOH601 2.3 32.5 1.0
O B:HOH602 2.3 62.7 1.0
CE1 B:HIS290 2.8 98.2 1.0
CD B:GLU330 2.8 80.9 1.0
OE1 B:GLU330 2.9 79.2 1.0
CD2 B:HIS285 3.1 93.6 1.0
CE1 B:HIS285 3.2 93.9 1.0
CD2 B:HIS290 3.4 95.4 1.0
OH B:TYR325 3.7 95.0 1.0
ND1 B:HIS290 4.0 84.1 1.0
CG B:GLU330 4.3 73.7 1.0
ND1 B:HIS285 4.3 79.4 1.0
CG B:HIS285 4.3 84.7 1.0
CG B:HIS290 4.3 72.6 1.0
OE1 B:GLU286 4.5 0.7 1.0
CB B:ALA345 4.6 59.4 1.0
CZ B:TYR325 4.7 89.5 1.0
CE2 B:TYR325 4.9 91.8 1.0
CG B:PRO281 4.9 90.6 1.0

Iron binding site 3 out of 4 in 5den

Go back to Iron Binding Sites List in 5den
Iron binding site 3 out of 4 in the The First Structure of A Full-Length Mammalian Phenylalanine Hydroxylase Reveals the Architecture of An Auto-Inhibited Tetramer


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 3 of The First Structure of A Full-Length Mammalian Phenylalanine Hydroxylase Reveals the Architecture of An Auto-Inhibited Tetramer within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Fe501

b:49.1
occ:0.61
 OE2 C:GLU330 2.1 99.6 1.0
NE2 C:HIS290 2.2 82.7 1.0
NE2 C:HIS285 2.3 0.2 1.0
O C:HOH601 2.3 56.0 1.0
O C:HOH602 2.4 48.5 1.0
CE1 C:HIS290 2.8 86.5 1.0
CD C:GLU330 2.8 0.6 1.0
OE1 C:GLU330 3.0 0.8 1.0
CD2 C:HIS285 3.2 0.6 1.0
CE1 C:HIS285 3.3 94.4 1.0
CD2 C:HIS290 3.3 83.5 1.0
OH C:TYR325 3.9 99.3 1.0
ND1 C:HIS290 4.0 80.2 1.0
CG C:HIS290 4.3 73.3 1.0
CG C:GLU330 4.3 94.0 1.0
CG C:HIS285 4.4 92.9 1.0
ND1 C:HIS285 4.4 86.8 1.0
OE1 C:GLU286 4.5 86.8 1.0
CB C:ALA345 4.7 86.0 1.0
CZ C:TYR325 4.9 81.5 1.0

Iron binding site 4 out of 4 in 5den

Go back to Iron Binding Sites List in 5den
Iron binding site 4 out of 4 in the The First Structure of A Full-Length Mammalian Phenylalanine Hydroxylase Reveals the Architecture of An Auto-Inhibited Tetramer


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 4 of The First Structure of A Full-Length Mammalian Phenylalanine Hydroxylase Reveals the Architecture of An Auto-Inhibited Tetramer within 5.0Å range:
probe atom residue distance (Å) B Occ
D:Fe501

b:83.2
occ:0.86
 OE2 D:GLU330 2.1 91.7 1.0
NE2 D:HIS290 2.2 84.8 1.0
NE2 D:HIS285 2.2 82.6 1.0
O D:HOH602 2.3 54.4 1.0
O D:HOH601 2.3 87.3 1.0
CE1 D:HIS290 3.0 81.0 1.0
CD D:GLU330 3.0 84.8 1.0
CD2 D:HIS285 3.1 79.2 1.0
OE1 D:GLU330 3.2 87.6 1.0
CD2 D:HIS290 3.3 80.3 1.0
CE1 D:HIS285 3.3 79.2 1.0
ND1 D:HIS290 4.1 72.8 1.0
OE1 D:GLU286 4.3 67.3 1.0
CG D:HIS285 4.3 68.6 1.0
CG D:HIS290 4.3 64.7 1.0
ND1 D:HIS285 4.3 53.8 1.0
OH D:TYR325 4.4 70.7 1.0
CG D:GLU330 4.4 84.0 1.0
CB D:ALA345 4.6 75.7 1.0
CG D:PRO281 4.6 71.5 1.0
CB D:PRO281 4.7 61.4 1.0

Reference:

E.C.Arturo, K.Gupta, A.Heroux, L.Stith, P.J.Cross, E.J.Parker, P.J.Loll, E.K.Jaffe. First Structure of Full-Length Mammalian Phenylalanine Hydroxylase Reveals the Architecture of An Autoinhibited Tetramer. Proc.Natl.Acad.Sci.Usa V. 113 2394 2016.
ISSN: ESSN 1091-6490
PubMed: 26884182
DOI: 10.1073/PNAS.1516967113
Page generated: Mon Aug 5 23:18:18 2024

Last articles

Zn in 9JPJ
Zn in 9JP7
Zn in 9JPK
Zn in 9JPL
Zn in 9GN6
Zn in 9GN7
Zn in 9GKU
Zn in 9GKW
Zn in 9GKX
Zn in 9GL0
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy