Iron in PDB 5f8p: A Novel Inhibitor of the Obesity-Related Protein Fto

The structure of A Novel Inhibitor of the Obesity-Related Protein Fto, PDB code: 5f8p was solved by J.Chai, B.Zhou, W.Liu, Z.Han, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	28.87 / 2.20
Space group	H 3
Cell size a, b, c (Å), α, β, γ (°)	142.218, 142.218, 83.028, 90.00, 90.00, 120.00
R / Rfree (%)	18.8 / 23.4

The structure of A Novel Inhibitor of the Obesity-Related Protein Fto also contains other interesting chemical elements:

Chlorine

(Cl)

2 atoms

The binding sites of Iron atom in the A Novel Inhibitor of the Obesity-Related Protein Fto (pdb code 5f8p). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total only one binding site of Iron was determined in the A Novel Inhibitor of the Obesity-Related Protein Fto, PDB code: 5f8p:

Iron binding site 1 out of 1 in the A Novel Inhibitor of the Obesity-Related Protein Fto


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of A Novel Inhibitor of the Obesity-Related Protein Fto within 5.0Å range: probe atom residue distance (Å) B Occ A:Fe604 b:90.4 occ:1.00 O5 A:AKG603 2.6 79.0 1.0 NE2 A:HIS307 2.6 37.0 1.0 C2 A:AKG603 2.7 77.8 1.0 OD1 A:ASP233 2.8 45.4 1.0 O A:HOH704 2.8 63.2 1.0 NE2 A:HIS231 3.0 44.1 1.0 C3 A:AKG603 3.0 67.9 1.0 C4 A:AKG603 3.3 57.8 1.0 O1 A:AKG603 3.5 78.6 1.0 CD2 A:HIS307 3.5 40.5 1.0 CE1 A:HIS231 3.6 43.1 1.0 CE1 A:HIS307 3.6 41.9 1.0 C1 A:AKG603 3.6 76.7 1.0 CG A:ASP233 3.6 45.2 1.0 OD2 A:ASP233 3.7 48.0 1.0 CD2 A:HIS231 4.2 45.2 1.0 NH2 A:ARG322 4.3 51.8 1.0 CG A:HIS307 4.7 43.0 1.0 ND1 A:HIS307 4.7 39.5 1.0 ND1 A:HIS231 4.8 49.1 1.0 C5 A:AKG603 4.8 54.0 1.0 O2 A:AKG603 4.9 68.9 1.0

J.Chai, B.Zhou, W.Liu, Z.Han. Crystal Structure of Fto-Chtb To Be Published.