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Atomistry » Iron » PDB 5foi-5g6d » 5fvv | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Iron » PDB 5foi-5g6d » 5fvv » |
Iron in PDB 5fvv: Structure of Human Nnos R354A G357D Mutant Heme Domain in Complex with 4-Methyl-6-(2-(5-(1-Methylpiperidin-4-Yl) Pyridin-3-Yl)Ethyl)Pyridin-2-AmineEnzymatic activity of Structure of Human Nnos R354A G357D Mutant Heme Domain in Complex with 4-Methyl-6-(2-(5-(1-Methylpiperidin-4-Yl) Pyridin-3-Yl)Ethyl)Pyridin-2-Amine
All present enzymatic activity of Structure of Human Nnos R354A G357D Mutant Heme Domain in Complex with 4-Methyl-6-(2-(5-(1-Methylpiperidin-4-Yl) Pyridin-3-Yl)Ethyl)Pyridin-2-Amine:
1.14.13.39; Protein crystallography data
The structure of Structure of Human Nnos R354A G357D Mutant Heme Domain in Complex with 4-Methyl-6-(2-(5-(1-Methylpiperidin-4-Yl) Pyridin-3-Yl)Ethyl)Pyridin-2-Amine, PDB code: 5fvv
was solved by
H.Li,
T.L.Poulos,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 5fvv:
The structure of Structure of Human Nnos R354A G357D Mutant Heme Domain in Complex with 4-Methyl-6-(2-(5-(1-Methylpiperidin-4-Yl) Pyridin-3-Yl)Ethyl)Pyridin-2-Amine also contains other interesting chemical elements:
Iron Binding Sites:
The binding sites of Iron atom in the Structure of Human Nnos R354A G357D Mutant Heme Domain in Complex with 4-Methyl-6-(2-(5-(1-Methylpiperidin-4-Yl) Pyridin-3-Yl)Ethyl)Pyridin-2-Amine
(pdb code 5fvv). This binding sites where shown within
5.0 Angstroms radius around Iron atom.
In total 2 binding sites of Iron where determined in the Structure of Human Nnos R354A G357D Mutant Heme Domain in Complex with 4-Methyl-6-(2-(5-(1-Methylpiperidin-4-Yl) Pyridin-3-Yl)Ethyl)Pyridin-2-Amine, PDB code: 5fvv: Jump to Iron binding site number: 1; 2; Iron binding site 1 out of 2 in 5fvvGo back to Iron Binding Sites List in 5fvv
Iron binding site 1 out
of 2 in the Structure of Human Nnos R354A G357D Mutant Heme Domain in Complex with 4-Methyl-6-(2-(5-(1-Methylpiperidin-4-Yl) Pyridin-3-Yl)Ethyl)Pyridin-2-Amine
Mono view Stereo pair view
Iron binding site 2 out of 2 in 5fvvGo back to Iron Binding Sites List in 5fvv
Iron binding site 2 out
of 2 in the Structure of Human Nnos R354A G357D Mutant Heme Domain in Complex with 4-Methyl-6-(2-(5-(1-Methylpiperidin-4-Yl) Pyridin-3-Yl)Ethyl)Pyridin-2-Amine
Mono view Stereo pair view
Reference:
H.Wang,
Y.Qin,
H.Li,
L.J.Roman,
P.Martasek,
T.L.Poulos,
R.B.Silverman.
Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibition By Optimization of the 2-Aminopyridine-Based Scaffold with A Pyridine Linker. J.Med.Chem. V. 59 4913 2016.
Page generated: Sun Dec 13 16:01:49 2020
ISSN: ISSN 0022-2623 PubMed: 27050842 DOI: 10.1021/ACS.JMEDCHEM.6B00273 |
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