Iron in PDB 5hu6: Structure of the T. Brucei Haptoglobin-Haemoglobin Receptor Bound to Human Haptolgobin-Haemoglobin

The structure of Structure of the T. Brucei Haptoglobin-Haemoglobin Receptor Bound to Human Haptolgobin-Haemoglobin, PDB code: 5hu6 was solved by H.Lane-Serff, M.K.Higgins, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	58.07 / 2.90
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	222.290, 56.560, 66.100, 90.00, 92.97, 90.00
R / Rfree (%)	19 / 22.6

The binding sites of Iron atom in the Structure of the T. Brucei Haptoglobin-Haemoglobin Receptor Bound to Human Haptolgobin-Haemoglobin (pdb code 5hu6). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total 2 binding sites of Iron where determined in the Structure of the T. Brucei Haptoglobin-Haemoglobin Receptor Bound to Human Haptolgobin-Haemoglobin, PDB code: 5hu6:
Jump to Iron binding site number: 1; 2;

Iron binding site 1 out of 2 in the Structure of the T. Brucei Haptoglobin-Haemoglobin Receptor Bound to Human Haptolgobin-Haemoglobin


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Structure of the T. Brucei Haptoglobin-Haemoglobin Receptor Bound to Human Haptolgobin-Haemoglobin within 5.0Å range: probe atom residue distance (Å) B Occ A:Fe201 b:60.2 occ:1.00 FE A:HEM201 0.0 60.2 1.0 ND A:HEM201 1.9 62.7 1.0 NA A:HEM201 2.0 63.9 1.0 NE2 A:HIS88 2.1 52.4 1.0 NC A:HEM201 2.1 55.5 1.0 NB A:HEM201 2.1 56.2 1.0 O1 A:OXY202 2.2 0.2 1.0 O2 A:OXY202 2.8 0.9 1.0 C1D A:HEM201 2.9 63.5 1.0 C4D A:HEM201 2.9 65.0 1.0 C1A A:HEM201 2.9 67.2 1.0 C4C A:HEM201 3.0 55.0 1.0 C4A A:HEM201 3.0 59.7 1.0 CE1 A:HIS88 3.0 53.1 1.0 C1C A:HEM201 3.1 51.6 1.0 CD2 A:HIS88 3.1 51.6 1.0 C1B A:HEM201 3.1 55.6 1.0 C4B A:HEM201 3.1 52.1 1.0 CHA A:HEM201 3.3 66.1 1.0 CHD A:HEM201 3.3 59.0 1.0 CHB A:HEM201 3.5 55.0 1.0 CHC A:HEM201 3.5 51.3 1.0 C2D A:HEM201 4.1 66.5 1.0 C2A A:HEM201 4.1 69.0 1.0 C3D A:HEM201 4.1 69.6 1.0 C3A A:HEM201 4.2 65.5 1.0 ND1 A:HIS88 4.2 53.3 1.0 C3C A:HEM201 4.2 50.5 1.0 CG A:HIS88 4.2 51.1 1.0 C2C A:HEM201 4.2 48.8 1.0 NE2 A:HIS59 4.3 81.5 1.0 C2B A:HEM201 4.4 55.0 1.0 C3B A:HEM201 4.4 53.5 1.0 CE1 A:HIS59 4.8 83.5 1.0 CG2 A:VAL63 4.9 51.8 1.0

Iron binding site 2 out of 2 in the Structure of the T. Brucei Haptoglobin-Haemoglobin Receptor Bound to Human Haptolgobin-Haemoglobin


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 2 of Structure of the T. Brucei Haptoglobin-Haemoglobin Receptor Bound to Human Haptolgobin-Haemoglobin within 5.0Å range: probe atom residue distance (Å) B Occ B:Fe201 b:51.5 occ:1.00 FE B:HEM201 0.0 51.5 1.0 ND B:HEM201 1.9 53.0 1.0 NA B:HEM201 2.0 59.9 1.0 O1 B:OXY202 2.1 68.9 1.0 NC B:HEM201 2.1 48.5 1.0 NB B:HEM201 2.1 53.8 1.0 NE2 B:HIS93 2.3 49.2 1.0 C4D B:HEM201 2.9 52.9 1.0 C1A B:HEM201 2.9 63.3 1.0 C1D B:HEM201 2.9 51.9 1.0 C4C B:HEM201 3.0 49.2 1.0 C4A B:HEM201 3.0 62.0 1.0 O2 B:OXY202 3.0 70.3 1.0 C1C B:HEM201 3.1 50.2 1.0 C1B B:HEM201 3.1 59.4 1.0 C4B B:HEM201 3.1 53.1 1.0 CE1 B:HIS93 3.2 51.4 1.0 CHA B:HEM201 3.3 58.9 1.0 CHD B:HEM201 3.4 48.3 1.0 CD2 B:HIS93 3.4 49.0 1.0 CHB B:HEM201 3.5 62.0 1.0 CHC B:HEM201 3.5 52.2 1.0 C3D B:HEM201 4.2 51.4 1.0 C2A B:HEM201 4.2 64.5 1.0 C3A B:HEM201 4.2 65.5 1.0 C2D B:HEM201 4.2 50.8 1.0 C3C B:HEM201 4.2 46.6 1.0 C2C B:HEM201 4.3 46.0 1.0 C2B B:HEM201 4.3 59.5 1.0 NE2 B:HIS64 4.4 50.6 1.0 C3B B:HEM201 4.4 56.7 1.0 ND1 B:HIS93 4.4 53.3 1.0 CG B:HIS93 4.5 50.4 1.0 CG2 B:VAL68 4.6 55.8 1.0 CE1 B:HIS64 5.0 51.9 1.0

H.Lane-Serff, P.Macgregor, E.D.Lowe, M.Carrington, M.K.Higgins. Structural Basis For Ligand and Innate Immunity Factor Uptake By the Trypanosome Haptoglobin-Haemoglobin Receptor. Elife V. 3 05553 2014.
ISSN: ESSN 2050-084X
PubMed: 25497229
DOI: 10.7554/ELIFE.05553