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Iron in PDB 5jkv: Human Placental Aromatase Cytochrome P450 (CYP19A1) at 2.75 Angstrom with Bound Polyethylene Glycol

Enzymatic activity of Human Placental Aromatase Cytochrome P450 (CYP19A1) at 2.75 Angstrom with Bound Polyethylene Glycol

All present enzymatic activity of Human Placental Aromatase Cytochrome P450 (CYP19A1) at 2.75 Angstrom with Bound Polyethylene Glycol:
1.14.14.14;

Protein crystallography data

The structure of Human Placental Aromatase Cytochrome P450 (CYP19A1) at 2.75 Angstrom with Bound Polyethylene Glycol, PDB code: 5jkv was solved by D.Ghosh, J.Lo, C.Egbuta, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 121.43 / 2.75
Space group P 32 2 1
Cell size a, b, c (Å), α, β, γ (°) 140.218, 140.218, 119.271, 90.00, 90.00, 120.00
R / Rfree (%) 21.4 / 23.6

Iron Binding Sites:

The binding sites of Iron atom in the Human Placental Aromatase Cytochrome P450 (CYP19A1) at 2.75 Angstrom with Bound Polyethylene Glycol (pdb code 5jkv). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total only one binding site of Iron was determined in the Human Placental Aromatase Cytochrome P450 (CYP19A1) at 2.75 Angstrom with Bound Polyethylene Glycol, PDB code: 5jkv:

Iron binding site 1 out of 1 in 5jkv

Go back to Iron Binding Sites List in 5jkv
Iron binding site 1 out of 1 in the Human Placental Aromatase Cytochrome P450 (CYP19A1) at 2.75 Angstrom with Bound Polyethylene Glycol


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Human Placental Aromatase Cytochrome P450 (CYP19A1) at 2.75 Angstrom with Bound Polyethylene Glycol within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Fe601

b:47.5
occ:1.00
 FE A:HEM601 0.0 47.5 1.0
NB A:HEM601 2.0 45.6 1.0
NA A:HEM601 2.0 44.6 1.0
NC A:HEM601 2.0 45.3 1.0
ND A:HEM601 2.1 45.5 1.0
SG A:CYS437 2.2 51.5 1.0
C4B A:HEM601 3.0 46.8 1.0
C1C A:HEM601 3.0 45.9 1.0
C1A A:HEM601 3.0 45.4 1.0
C1B A:HEM601 3.1 45.5 1.0
C4A A:HEM601 3.1 45.6 1.0
C4D A:HEM601 3.1 46.6 1.0
C4C A:HEM601 3.1 46.4 1.0
C1D A:HEM601 3.1 46.3 1.0
CHC A:HEM601 3.4 46.4 1.0
CHA A:HEM601 3.4 45.9 1.0
CHB A:HEM601 3.4 45.9 1.0
CB A:CYS437 3.5 52.9 1.0
CHD A:HEM601 3.5 45.9 1.0
C19 A:ASD602 3.8 48.0 1.0
CA A:CYS437 4.2 54.2 1.0
C3B A:HEM601 4.2 47.0 1.0
C2B A:HEM601 4.3 46.4 1.0
C2A A:HEM601 4.3 46.0 1.0
C3A A:HEM601 4.3 45.2 1.0
C2C A:HEM601 4.3 46.5 1.0
C3C A:HEM601 4.3 46.9 1.0
C3D A:HEM601 4.3 47.0 1.0
C2D A:HEM601 4.3 46.7 1.0
C1 A:ASD602 4.8 49.5 1.0
N A:ALA438 4.9 56.5 1.0
N A:GLY439 4.9 57.7 1.0
C A:CYS437 4.9 56.4 1.0
C2 A:ASD602 5.0 49.5 1.0

Reference:

D.Ghosh, C.Egbuta, J.Lo. Testosterone Complex and Non-Steroidal Ligands of Human Aromatase. J. Steroid Biochem. Mol. 2018BIOL..
ISSN: ISSN 1879-1220
PubMed: 29476820
DOI: 10.1016/J.JSBMB.2018.02.009
Page generated: Tue Aug 6 02:31:37 2024

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