Iron in PDB 5juy: Active Human Apoptosome with Procaspase-9

All present enzymatic activity of Active Human Apoptosome with Procaspase-9:
3.4.22.62;

The binding sites of Iron atom in the Active Human Apoptosome with Procaspase-9 (pdb code 5juy). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total 7 binding sites of Iron where determined in the Active Human Apoptosome with Procaspase-9, PDB code: 5juy:
Jump to Iron binding site number: 1; 2; 3; 4; 5; 6; 7;

Iron binding site 1 out of 7 in the Active Human Apoptosome with Procaspase-9


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Active Human Apoptosome with Procaspase-9 within 5.0Å range: probe atom residue distance (Å) B Occ H:Fe500 b:50.0 occ:1.00 FE H:HEC500 0.0 50.0 1.0 ND H:HEC500 2.0 50.0 1.0 NC H:HEC500 2.0 50.0 1.0 NA H:HEC500 2.1 50.0 1.0 NB H:HEC500 2.1 50.0 1.0 NE2 H:HIS18 2.6 50.0 1.0 CE1 H:HIS18 2.9 50.0 1.0 SD H:MET80 3.0 50.0 1.0 C1B H:HEC500 3.0 50.0 1.0 C1D H:HEC500 3.0 50.0 1.0 C4C H:HEC500 3.0 50.0 1.0 C4B H:HEC500 3.0 50.0 1.0 C4A H:HEC500 3.1 50.0 1.0 C4D H:HEC500 3.1 50.0 1.0 C1A H:HEC500 3.1 50.0 1.0 C1C H:HEC500 3.1 50.0 1.0 CE H:MET80 3.4 50.0 1.0 CHD H:HEC500 3.4 50.0 1.0 CHB H:HEC500 3.4 50.0 1.0 CHA H:HEC500 3.4 50.0 1.0 CHC H:HEC500 3.4 50.0 1.0 CG H:MET80 3.5 50.0 1.0 CD2 H:HIS18 3.9 50.0 1.0 ND1 H:HIS18 4.2 50.0 1.0 C2B H:HEC500 4.2 50.0 1.0 C3B H:HEC500 4.2 50.0 1.0 C3A H:HEC500 4.3 50.0 1.0 C2A H:HEC500 4.3 50.0 1.0 C2D H:HEC500 4.3 50.0 1.0 C3C H:HEC500 4.3 50.0 1.0 C2C H:HEC500 4.3 50.0 1.0 C3D H:HEC500 4.3 50.0 1.0 CB H:MET80 4.3 50.0 1.0 CG H:HIS18 4.7 50.0 1.0

Iron binding site 2 out of 7 in the Active Human Apoptosome with Procaspase-9


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 2 of Active Human Apoptosome with Procaspase-9 within 5.0Å range: probe atom residue distance (Å) B Occ I:Fe500 b:50.0 occ:1.00 FE I:HEC500 0.0 50.0 1.0 ND I:HEC500 2.0 50.0 1.0 NC I:HEC500 2.0 50.0 1.0 NA I:HEC500 2.1 50.0 1.0 NB I:HEC500 2.1 50.0 1.0 NE2 I:HIS18 2.6 50.0 1.0 CE1 I:HIS18 2.9 50.0 1.0 SD I:MET80 3.0 50.0 1.0 C1B I:HEC500 3.0 50.0 1.0 C1D I:HEC500 3.0 50.0 1.0 C4C I:HEC500 3.0 50.0 1.0 C4B I:HEC500 3.0 50.0 1.0 C4A I:HEC500 3.1 50.0 1.0 C4D I:HEC500 3.1 50.0 1.0 C1A I:HEC500 3.1 50.0 1.0 C1C I:HEC500 3.1 50.0 1.0 CE I:MET80 3.4 50.0 1.0 CHD I:HEC500 3.4 50.0 1.0 CHB I:HEC500 3.4 50.0 1.0 CHA I:HEC500 3.4 50.0 1.0 CHC I:HEC500 3.4 50.0 1.0 CG I:MET80 3.5 50.0 1.0 CD2 I:HIS18 3.9 50.0 1.0 ND1 I:HIS18 4.2 50.0 1.0 C2B I:HEC500 4.2 50.0 1.0 C3B I:HEC500 4.2 50.0 1.0 C3A I:HEC500 4.3 50.0 1.0 C2A I:HEC500 4.3 50.0 1.0 C2D I:HEC500 4.3 50.0 1.0 C3C I:HEC500 4.3 50.0 1.0 C2C I:HEC500 4.3 50.0 1.0 C3D I:HEC500 4.3 50.0 1.0 CB I:MET80 4.3 50.0 1.0 CG I:HIS18 4.7 50.0 1.0

Iron binding site 3 out of 7 in the Active Human Apoptosome with Procaspase-9


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 3 of Active Human Apoptosome with Procaspase-9 within 5.0Å range: probe atom residue distance (Å) B Occ J:Fe500 b:50.0 occ:1.00 FE J:HEC500 0.0 50.0 1.0 ND J:HEC500 2.0 50.0 1.0 NC J:HEC500 2.0 50.0 1.0 NA J:HEC500 2.1 50.0 1.0 NB J:HEC500 2.1 50.0 1.0 NE2 J:HIS18 2.6 50.0 1.0 CE1 J:HIS18 2.9 50.0 1.0 SD J:MET80 3.0 50.0 1.0 C1B J:HEC500 3.0 50.0 1.0 C1D J:HEC500 3.0 50.0 1.0 C4C J:HEC500 3.0 50.0 1.0 C4B J:HEC500 3.0 50.0 1.0 C4A J:HEC500 3.1 50.0 1.0 C4D J:HEC500 3.1 50.0 1.0 C1A J:HEC500 3.1 50.0 1.0 C1C J:HEC500 3.1 50.0 1.0 CE J:MET80 3.4 50.0 1.0 CHD J:HEC500 3.4 50.0 1.0 CHB J:HEC500 3.4 50.0 1.0 CHA J:HEC500 3.4 50.0 1.0 CHC J:HEC500 3.4 50.0 1.0 CG J:MET80 3.5 50.0 1.0 CD2 J:HIS18 3.9 50.0 1.0 ND1 J:HIS18 4.2 50.0 1.0 C2B J:HEC500 4.2 50.0 1.0 C3B J:HEC500 4.2 50.0 1.0 C3A J:HEC500 4.3 50.0 1.0 C2A J:HEC500 4.3 50.0 1.0 C2D J:HEC500 4.3 50.0 1.0 C3C J:HEC500 4.3 50.0 1.0 C2C J:HEC500 4.3 50.0 1.0 C3D J:HEC500 4.3 50.0 1.0 CB J:MET80 4.3 50.0 1.0 CG J:HIS18 4.7 50.0 1.0

Iron binding site 4 out of 7 in the Active Human Apoptosome with Procaspase-9


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 4 of Active Human Apoptosome with Procaspase-9 within 5.0Å range: probe atom residue distance (Å) B Occ K:Fe500 b:50.0 occ:1.00 FE K:HEC500 0.0 50.0 1.0 ND K:HEC500 2.0 50.0 1.0 NC K:HEC500 2.0 50.0 1.0 NA K:HEC500 2.1 50.0 1.0 NB K:HEC500 2.1 50.0 1.0 NE2 K:HIS18 2.6 50.0 1.0 CE1 K:HIS18 2.9 50.0 1.0 SD K:MET80 3.0 50.0 1.0 C1B K:HEC500 3.0 50.0 1.0 C1D K:HEC500 3.0 50.0 1.0 C4C K:HEC500 3.0 50.0 1.0 C4B K:HEC500 3.0 50.0 1.0 C4A K:HEC500 3.1 50.0 1.0 C4D K:HEC500 3.1 50.0 1.0 C1A K:HEC500 3.1 50.0 1.0 C1C K:HEC500 3.1 50.0 1.0 CE K:MET80 3.4 50.0 1.0 CHD K:HEC500 3.4 50.0 1.0 CHB K:HEC500 3.4 50.0 1.0 CHA K:HEC500 3.4 50.0 1.0 CHC K:HEC500 3.4 50.0 1.0 CG K:MET80 3.5 50.0 1.0 CD2 K:HIS18 3.9 50.0 1.0 ND1 K:HIS18 4.2 50.0 1.0 C2B K:HEC500 4.2 50.0 1.0 C3B K:HEC500 4.2 50.0 1.0 C3A K:HEC500 4.3 50.0 1.0 C2A K:HEC500 4.3 50.0 1.0 C2D K:HEC500 4.3 50.0 1.0 C3C K:HEC500 4.3 50.0 1.0 C2C K:HEC500 4.3 50.0 1.0 C3D K:HEC500 4.3 50.0 1.0 CB K:MET80 4.3 50.0 1.0 CG K:HIS18 4.7 50.0 1.0

Iron binding site 5 out of 7 in the Active Human Apoptosome with Procaspase-9


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 5 of Active Human Apoptosome with Procaspase-9 within 5.0Å range: probe atom residue distance (Å) B Occ L:Fe500 b:50.0 occ:1.00 FE L:HEC500 0.0 50.0 1.0 ND L:HEC500 2.0 50.0 1.0 NC L:HEC500 2.0 50.0 1.0 NA L:HEC500 2.1 50.0 1.0 NB L:HEC500 2.1 50.0 1.0 NE2 L:HIS18 2.6 50.0 1.0 CE1 L:HIS18 2.9 50.0 1.0 SD L:MET80 3.0 50.0 1.0 C1B L:HEC500 3.0 50.0 1.0 C1D L:HEC500 3.0 50.0 1.0 C4C L:HEC500 3.0 50.0 1.0 C4B L:HEC500 3.0 50.0 1.0 C4A L:HEC500 3.1 50.0 1.0 C4D L:HEC500 3.1 50.0 1.0 C1A L:HEC500 3.1 50.0 1.0 C1C L:HEC500 3.1 50.0 1.0 CE L:MET80 3.4 50.0 1.0 CHD L:HEC500 3.4 50.0 1.0 CHB L:HEC500 3.4 50.0 1.0 CHA L:HEC500 3.4 50.0 1.0 CHC L:HEC500 3.4 50.0 1.0 CG L:MET80 3.5 50.0 1.0 CD2 L:HIS18 3.9 50.0 1.0 ND1 L:HIS18 4.2 50.0 1.0 C2B L:HEC500 4.2 50.0 1.0 C3B L:HEC500 4.2 50.0 1.0 C3A L:HEC500 4.3 50.0 1.0 C2A L:HEC500 4.3 50.0 1.0 C2D L:HEC500 4.3 50.0 1.0 C3C L:HEC500 4.3 50.0 1.0 C2C L:HEC500 4.3 50.0 1.0 C3D L:HEC500 4.3 50.0 1.0 CB L:MET80 4.3 50.0 1.0 CG L:HIS18 4.7 50.0 1.0

Iron binding site 6 out of 7 in the Active Human Apoptosome with Procaspase-9


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 6 of Active Human Apoptosome with Procaspase-9 within 5.0Å range: probe atom residue distance (Å) B Occ M:Fe500 b:50.0 occ:1.00 FE M:HEC500 0.0 50.0 1.0 ND M:HEC500 2.0 50.0 1.0 NC M:HEC500 2.0 50.0 1.0 NA M:HEC500 2.1 50.0 1.0 NB M:HEC500 2.1 50.0 1.0 NE2 M:HIS18 2.6 50.0 1.0 CE1 M:HIS18 2.9 50.0 1.0 SD M:MET80 3.0 50.0 1.0 C1B M:HEC500 3.0 50.0 1.0 C1D M:HEC500 3.0 50.0 1.0 C4C M:HEC500 3.0 50.0 1.0 C4B M:HEC500 3.0 50.0 1.0 C4A M:HEC500 3.1 50.0 1.0 C4D M:HEC500 3.1 50.0 1.0 C1A M:HEC500 3.1 50.0 1.0 C1C M:HEC500 3.1 50.0 1.0 CE M:MET80 3.4 50.0 1.0 CHD M:HEC500 3.4 50.0 1.0 CHB M:HEC500 3.4 50.0 1.0 CHA M:HEC500 3.4 50.0 1.0 CHC M:HEC500 3.4 50.0 1.0 CG M:MET80 3.5 50.0 1.0 CD2 M:HIS18 3.9 50.0 1.0 ND1 M:HIS18 4.2 50.0 1.0 C2B M:HEC500 4.2 50.0 1.0 C3B M:HEC500 4.2 50.0 1.0 C3A M:HEC500 4.3 50.0 1.0 C2A M:HEC500 4.3 50.0 1.0 C2D M:HEC500 4.3 50.0 1.0 C3C M:HEC500 4.3 50.0 1.0 C2C M:HEC500 4.3 50.0 1.0 C3D M:HEC500 4.3 50.0 1.0 CB M:MET80 4.3 50.0 1.0 CG M:HIS18 4.7 50.0 1.0

Iron binding site 7 out of 7 in the Active Human Apoptosome with Procaspase-9


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 7 of Active Human Apoptosome with Procaspase-9 within 5.0Å range: probe atom residue distance (Å) B Occ N:Fe500 b:50.0 occ:1.00 FE N:HEC500 0.0 50.0 1.0 ND N:HEC500 2.0 50.0 1.0 NC N:HEC500 2.0 50.0 1.0 NA N:HEC500 2.1 50.0 1.0 NB N:HEC500 2.1 50.0 1.0 NE2 N:HIS18 2.6 50.0 1.0 CE1 N:HIS18 2.9 50.0 1.0 SD N:MET80 3.0 50.0 1.0 C1B N:HEC500 3.0 50.0 1.0 C1D N:HEC500 3.0 50.0 1.0 C4C N:HEC500 3.0 50.0 1.0 C4B N:HEC500 3.0 50.0 1.0 C4A N:HEC500 3.1 50.0 1.0 C4D N:HEC500 3.1 50.0 1.0 C1A N:HEC500 3.1 50.0 1.0 C1C N:HEC500 3.1 50.0 1.0 CE N:MET80 3.4 50.0 1.0 CHD N:HEC500 3.4 50.0 1.0 CHB N:HEC500 3.4 50.0 1.0 CHA N:HEC500 3.4 50.0 1.0 CHC N:HEC500 3.4 50.0 1.0 CG N:MET80 3.5 50.0 1.0 CD2 N:HIS18 3.9 50.0 1.0 ND1 N:HIS18 4.2 50.0 1.0 C2B N:HEC500 4.2 50.0 1.0 C3B N:HEC500 4.2 50.0 1.0 C3A N:HEC500 4.3 50.0 1.0 C2A N:HEC500 4.3 50.0 1.0 C2D N:HEC500 4.3 50.0 1.0 C3C N:HEC500 4.3 50.0 1.0 C3D N:HEC500 4.3 50.0 1.0 C2C N:HEC500 4.3 50.0 1.0 CB N:MET80 4.3 50.0 1.0 CG N:HIS18 4.7 50.0 1.0

T.C.Cheng, C.Hong, I.V.Akey, S.Yuan, C.W.Akey. A Near Atomic Structure of the Active Human Apoptosome. Elife V. 5 2016.
ISSN: ESSN 2050-084X
PubMed: 27697150
DOI: 10.7554/ELIFE.17755