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Atomistry » Iron » PDB 5jsh-5kja » 5k7k » |
Iron in PDB 5k7k: Design and Optimization of Biaryl Ether Aryl Sulfonamides As Selective Inhibitors of NAV1.7: Discovery of Clinical Candidate Pf-05089771Enzymatic activity of Design and Optimization of Biaryl Ether Aryl Sulfonamides As Selective Inhibitors of NAV1.7: Discovery of Clinical Candidate Pf-05089771
All present enzymatic activity of Design and Optimization of Biaryl Ether Aryl Sulfonamides As Selective Inhibitors of NAV1.7: Discovery of Clinical Candidate Pf-05089771:
1.14.13.80; Protein crystallography data
The structure of Design and Optimization of Biaryl Ether Aryl Sulfonamides As Selective Inhibitors of NAV1.7: Discovery of Clinical Candidate Pf-05089771, PDB code: 5k7k
was solved by
N.Swain,
J.Chrencik,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 5k7k:
The structure of Design and Optimization of Biaryl Ether Aryl Sulfonamides As Selective Inhibitors of NAV1.7: Discovery of Clinical Candidate Pf-05089771 also contains other interesting chemical elements:
Iron Binding Sites:
The binding sites of Iron atom in the Design and Optimization of Biaryl Ether Aryl Sulfonamides As Selective Inhibitors of NAV1.7: Discovery of Clinical Candidate Pf-05089771
(pdb code 5k7k). This binding sites where shown within
5.0 Angstroms radius around Iron atom.
In total only one binding site of Iron was determined in the Design and Optimization of Biaryl Ether Aryl Sulfonamides As Selective Inhibitors of NAV1.7: Discovery of Clinical Candidate Pf-05089771, PDB code: 5k7k: Iron binding site 1 out of 1 in 5k7kGo back to![]() ![]()
Iron binding site 1 out
of 1 in the Design and Optimization of Biaryl Ether Aryl Sulfonamides As Selective Inhibitors of NAV1.7: Discovery of Clinical Candidate Pf-05089771
![]() Mono view ![]() Stereo pair view
Reference:
N.A.Swain,
D.Batchelor,
S.Beaudoin,
B.M.Bechle,
P.A.Bradley,
A.D.Brown,
B.Brown,
K.J.Butcher,
R.P.Butt,
M.L.Chapman,
S.Denton,
D.Ellis,
S.R.G.Galan,
S.M.Gaulier,
B.S.Greener,
M.J.De Groot,
M.S.Glossop,
I.K.Gurrell,
J.Hannam,
M.S.Johnson,
Z.Lin,
C.J.Markworth,
B.E.Marron,
D.S.Millan,
S.Nakagawa,
A.Pike,
D.Printzenhoff,
D.J.Rawson,
S.J.Ransley,
S.M.Reister,
K.Sasaki,
R.I.Storer,
P.A.Stupple,
C.W.West.
Discovery of Clinical Candidate 4-[2-(5-Amino-1H-Pyrazol-4-Yl) -4-Chlorophenoxy]-5-Chloro-2-Fluoro-N-1, 3-Thiazol-4-Ylbenzenesulfonamide (Pf-05089771): Design and Optimization of Diaryl Ether Aryl Sulfonamides As Selective Inhibitors of NAV1.7. J. Med. Chem. V. 60 7029 2017.
Page generated: Tue Aug 6 03:05:32 2024
ISSN: ISSN 1520-4804 PubMed: 28682065 DOI: 10.1021/ACS.JMEDCHEM.7B00598 |
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